The stem cell hypothesis in head and neck cancer.

Abstract:

:Cancer stem cells (CSCs) are tumoral cells which have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. In the last 10 years the pathological meaning and the existence of CSCs have been matter of discussion and a large number of articles have been published about the role that these cells play in the development and maintenance of the tumors. Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer worldwide: early diagnosis of high-risk premalignant lesions are high priorities for reducing deaths due to head and neck cancer. In the last years the CSCs hypothesis has been faced also for head and neck cancer, with the aim of a better comprehension of the tumor biology and an early diagnosis. The evidence that the development of a tumor comes from a small number of cells with stem-like characteristic, could bring too to the identification of therapies against these cellular target, fundamental for maintenance and progression of the lesion. Here, a literature review has been reported about the detection of supposed CSCs in head and neck cancer.

journal_name

J Cell Biochem

authors

Graziano A,d'Aquino R,Tirino V,Desiderio V,Rossi A,Pirozzi G

doi

10.1002/jcb.21436

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

408-12

issue

2

eissn

0730-2312

issn

1097-4644

journal_volume

103

pub_type

杂志文章,评审
  • Anti-inflammatory response to acute exercise is related with intensity and physical fitness.

    abstract:PURPOSE:The relationship between inflammatory markers and energetic metabolism has been explored. However, the relationship between exercise intensity and fitness status is unclear, and it is necessary to understand this relationship to apply specific exercise guidance. The purpose of the study was to analyze metabolic...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27810

    authors: Antunes BM,Campos EZ,Dos Santos RVT,Rosa-Neto JC,Franchini E,Bishop NC,Lira FS

    更新日期:2019-04-01 00:00:00

  • Effects of resveratrol on H(2)O(2)-induced apoptosis and expression of SIRTs in H9c2 cells.

    abstract::Resveratrol, a polyphenol found in fruits, has been demonstrated to activate Sir2. Though many studies have demonstrated that resveratrol can activate SIRT1, whether it has effect on other sirtuins (SIRT2-7) are unknown. The present study shows that exposure of H9c2 cells to 50 microM H(2)O(2) for 6 h caused a signifi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22169

    authors: Yu W,Fu YC,Zhou XH,Chen CJ,Wang X,Lin RB,Wang W

    更新日期:2009-07-01 00:00:00

  • Remodelling of the nuclear periphery during muscle cell differentiation in vitro.

    abstract::We have examined the composition and ultrastructure of the nuclear periphery during in vitro myogenesis of the rat myoblast cell line, L6E9. Immunofluorescence labelling and immunoblotting showed that lamins A/C and B were all present in undifferentiated cells, but that they increased significantly before extensive ce...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(199607)62:1<76::aid-jcb9>3

    authors: Chaly N,Munro SB,Swallow MA

    更新日期:1996-07-01 00:00:00

  • Transcriptional regulation of the lysozyme gene in airway gland serous cells.

    abstract::Lysozyme is expressed in serous, but not mucous, cells of the tracheobronchial glands and thereby constitutes a marker of the serous cell lineage in these glands. To identify DNA regulatory elements and transcription factors mediating the commitment of progenitor cells to the serous cell lineage, we have characterized...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4644(19960601)61:3%3C350::AID-J

    authors: Kai H,Takeuchi K,Ohmori H,Li JD,Gallup M,Basbaum C

    更新日期:1996-06-01 00:00:00

  • Matrix influence on the tumor cell stimulation of fibroblast collagenase production.

    abstract::Cocultures of rabbit fibroblasts and mouse B-16 melanoma cells produce increased levels of collagenase against type I collagen. This stimulatory effect was also found when fibroblasts were cultured in conditioned media from tumor cells. However, the level of the stimulatory factor in conditioned media was influenced b...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240280107

    authors: Biswas C

    更新日期:1985-01-01 00:00:00

  • Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF.

    abstract::TNF is a key inflammatory cytokine with antiviral properties. Human adenoviruses encode several intracellular proteins that mediate the effects of TNF. Expression of the adenovirus immediate early E1A proteins induces viral genes and a host of cellular genes, drives G0 cells into S-phase, and induces apoptosis and sus...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.240530410

    authors: Wold WS

    更新日期:1993-12-01 00:00:00

  • Melanoma cancer vaccines and anti-tumor T cell responses.

    abstract::Melanoma is a disease which has been shown to be responsive to immune intervention. This has been suggested by reports of spontaneous responses of metastatic disease with strong immune infiltrates, and supported by recent data correlating clinical response after IFNalpha treatment with development of generalized autoi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.21473

    authors: Vujanovic L,Butterfield LH

    更新日期:2007-10-01 00:00:00

  • Hemolymph-dependent and -independent responses in Drosophila immune tissue.

    abstract::Insects possess an antimicrobial defense response that is similar to the mammalian innate immune response. The innate immune system is designed to recognize conserved components of microorganisms called pathogen-associated molecular patterns (PAMPs). How host receptors detect PAMPs and transmit the signals to mount th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20123

    authors: Bettencourt R,Asha H,Dearolf C,Ip YT

    更新日期:2004-07-01 00:00:00

  • cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation.

    abstract::Proliferation of endothelial cells is regulated by angiogenic and antiangiogenic factors whose actions are mediated by complex interactions of multiple signaling pathways. Both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) stimulate cell proliferation and activate the mitogen-acti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:

    authors: D'Angelo G,Lee H,Weiner RI

    更新日期:1997-12-01 00:00:00

  • Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis.

    abstract::Small molecule inhibitors of cyclin-dependent kinase 5 (CDK5) protect neurons from cell death following various insults. To elucidate the cellular mechanism of action we investigated changes in protein phosphorylation in cultured rat cerebellar granule neurons after administration of the CDK5 inhibitor Indolinone A. B...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20463

    authors: Gillardon F,Schrattenholz A,Sommer B

    更新日期:2005-07-01 00:00:00

  • circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma.

    abstract::Circular RNAs (circRNAs) are a newly validated type of noncoding RNAs recently found to be deregulated in several human cancers. More accurate and specific noninvasive biomarkers are strongly needed for better diagnosis and prognosis of hepatocellular carcinoma (HCC). We performed a bioinformatics analysis to retrieve...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28045

    authors: Matboli M,Shafei AE,Ali MA,Ashry AM,Kamal KM,Agag MA,Reda I,Tash EF,Ali M

    更新日期:2018-11-13 00:00:00

  • Construction of lncRNA-associated ceRNA networks to identify prognostic lncRNA biomarkers for glioblastoma.

    abstract::Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of tumors. However, the role of lncRNAs, especially the lncRNA-related ceRNA regulatory network, in glioblastoma (GBM) has not been fully elucidated. The goal of the current study was ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29625

    authors: Liu Z,Wang X,Yang G,Zhong C,Zhang R,Ye J,Zhong Y,Hu J,Ozal B,Zhao S

    更新日期:2020-07-01 00:00:00

  • Choline and methionine regulate lipid metabolism via the AMPK signaling pathway in hepatocytes exposed to high concentrations of nonesterified fatty acids.

    abstract::High concentrations of nonesterified fatty acids (NEFAs) and β-hydroxybutyric acid (BHBA) induce lipid peroxidation, resulting in liver damage. Choline and methionine (Met) can promote energy balance and benefit liver health in transition dairy cows; however, the regulating mechanism remains unclear. In the present st...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29494

    authors: Shen J,Sun B,Yu C,Cao Y,Cai C,Yao J

    更新日期:2019-11-03 00:00:00

  • Mapping of an origin of DNA replication near the transcriptional promoter of the human HPRT gene.

    abstract::A quantitative PCR method was used to map a functional origin of DNA replication in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in normal human fibroblasts. This PCR method measures the abundance of specific sequences in short fragments of newly replicated DNA from logarithmically growing cells. Qua...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10136

    authors: Cohen SM,Brylawski BP,Cordeiro-Stone M,Kaufman DG

    更新日期:2002-01-01 00:00:00

  • Ecto-alkaline phosphatase activity identified at physiological pH range on intact P19 and HL-60 cells is induced by retinoic acid.

    abstract::The activity of membrane-bound alkaline phosphatase (ALP) expressed on the external surface of cultured murine P19 teratocarcinoma and human HL-60 myeloblastic leukemia cells was studied at physiological pH using p-nitrophenylphosphate (pNPP) as substrate. The rate of substrate hydrolysis catalyzed by intact viable ce...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(20000301)76:3<420::aid-jcb

    authors: Scheibe RJ,Kuehl H,Krautwald S,Meissner JD,Mueller WH

    更新日期:2000-01-01 00:00:00

  • N-cadherin mediated distribution of beta-catenin alters MAP kinase and BMP-2 signaling on chondrogenesis-related gene expression.

    abstract::We have examined the effect of calcium-dependent adhesion, mediated by N-cadherin, on cell signaling during chondrogenesis of multipotential embryonic mouse C3H10T1/2 cells. The activity of chondrogenic genes, type II collagen, aggrecan, and Sox9 were examined in monolayer (non-chondrogenic), and micromass (chondrogen...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20396

    authors: Modarresi R,Lafond T,Roman-Blas JA,Danielson KG,Tuan RS,Seghatoleslami MR

    更新日期:2005-05-01 00:00:00

  • Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

    abstract::Transient receptor potential cation channel-2 (TRPP2) is a nonspecific Ca2+ -dependent cation channel with versatile functions including control of extracellular calcium entry at the plasma membrane, release of intracellular calcium ([Ca2+ ]i) from internal stores of endoplasmic reticulum, and calcium-dependent mechan...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27376

    authors: Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

    更新日期:2018-12-01 00:00:00

  • Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism.

    abstract::Adult human mesenchymal stem cells (MSCs) hold promise for an increasing list of therapeutic uses due to their ease of isolation, expansion, and multi-lineage differentiation potential. To maximize the clinical potential of MSCs, the underlying mechanisms by which MSC functionality is controlled must be understood. We...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22289

    authors: Pricola KL,Kuhn NZ,Haleem-Smith H,Song Y,Tuan RS

    更新日期:2009-10-15 00:00:00

  • Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells.

    abstract::Induced pluripotent stem cells (iPSC) hold tremendous potential for personalized cell-based repair strategies to treat musculoskeletal disorders. To establish human iPSCs as a potential source of viable chondroprogenitors for articular cartilage repair, we assessed the in vitro chondrogenic potential of the pluripoten...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24388

    authors: Guzzo RM,Gibson J,Xu RH,Lee FY,Drissi H

    更新日期:2013-02-01 00:00:00

  • The role of membrane lectins in Dictyostelium discoideum aggregation as ascertained by specific univalent antibodies against discoidin I.

    abstract::Antibodies against pure discoidin I have been used as a tool to ascertain the role of this lectin in aggregation of Dictyostelium discoideum. Discoidin I is widely expressed over the cell surface of aggregation-competent AX-2 cells, as ascertained by indirect immunofluorescence with specific (antidiscoidin I) antibodi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240250104

    authors: Cano A,Pestaña A

    更新日期:1984-01-01 00:00:00

  • Possible protective mechanisms exerted by metformin or metformin and vitamin E in isoproterenol-induced cardiac injury.

    abstract::Several studies have reported that metformin is cardioprotective for diabetic and non-diabetic ischemic hearts through mechanisms that cannot be entirely attributed to its anti-hyperglycemic effect. This study was designed to investigate the cardioprotective effects of metformin with and without vitamin E after induct...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26530

    authors: Al-Rasheed NM,Al-Rasheed NM,Al-Rabeeah DA,Al-Barrak HS,Al-Salman SA,Ibrahim SA,Al-Hassab SA,Al-Amin MA,Hasan IH,Al-Ajmi HN,Al-Shammari TK

    更新日期:2018-05-01 00:00:00

  • Simultaneous contraction and buckling of stress fibers in individual cells.

    abstract::It has been proposed that buckling of actin stress fibers (SFs) may be associated with their disassembly. However, much of the detail remains unknown partly because the use of an elastic membrane sheet, conventionally necessary for inducing SF buckling with a mechanical compression to adherent cells, may limit high qu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.23410

    authors: Deguchi S,Matsui TS,Sato M

    更新日期:2012-03-01 00:00:00

  • DNA methylation in embryonic stem cells.

    abstract::Embryonic stem cells (ESCs) are pluripotent, self-renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in control of pluripotence and differe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.22374

    authors: Altun G,Loring JF,Laurent LC

    更新日期:2010-01-01 00:00:00

  • Chromatin modification of the human imprinted NDN (necdin) gene detected by in vivo footprinting.

    abstract::Allele-specific transcription is a characteristic feature of imprinted genes. Many imprinted genes are also transcribed in a tissue- or cell type-specific manner. Overlapping epigenetic signals must, therefore, modulate allele-specific and tissue-specific expression at imprinted loci. In addition, long-range interacti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20365

    authors: Hanel ML,Lau JC,Paradis I,Drouin R,Wevrick R

    更新日期:2005-04-01 00:00:00

  • Nuclear factor 1 is a component of the nuclear matrix.

    abstract::Chicken histone H5 is an H1-like linker histone that is expressed only in nucleated erythrocytes. The histone H5 promoter has binding sites for Sp1 (a high affinity site) and UPE-binding protein, while the 3' erythroid-specific enhancer has binding sites for Sp1 (one moderate and three weak affinity), GATA-1, and NF1....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240550212

    authors: Sun JM,Chen HY,Davie JR

    更新日期:1994-06-01 00:00:00

  • Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors.

    abstract::Bone marrow-derived stromal cells (BMSC) possess a population of vascular progenitor cells that enable them to acquire a histology and immunophenotype coherent with endothelial cells (EC). Recent evidence indicates that a hypoxic environment such as that encountered in tumor masses regulates BMSC angiogenic properties...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10763

    authors: Annabi B,Naud E,Lee YT,Eliopoulos N,Galipeau J

    更新日期:2004-04-15 00:00:00

  • Protein tyrosine phosphatase SHP-1 specifically recognizes C-terminal residues of its substrates via helix alpha0.

    abstract::The catalytic domain of protein tyrosine phosphatase SHP-1 possesses distinct substrate specificity. It recognizes the P-3 to P-5 residues of its substrates via the beta5-loop-beta6 region. To study the substrate specificity further, we determined the structure of the catalytic domain of SHP-1 (C455S) complexed with a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.1195

    authors: Yang J,Cheng Z,Niu T,Liang X,Zhao ZJ,Zhou GW

    更新日期:2001-06-26 00:00:00

  • The influence of MicroRNA-150 in Osteoblast Matrix Mineralization.

    abstract::This study investigated the influence of miR-150 expression on osteoblast matrix mineralization and its mechanisms. The mouse osteoblast cell line MC3T3-E1 was used as an in vitro model of bone formation. On the fifth day of mineralization, transfection experiments using agomiR-150, agomiR-NC, antagomiR-150 antagomiR-...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25245

    authors: Dong CL,Liu HZ,Zhang ZC,Zhao HL,Zhao H,Huang Y,Yao JH,Sun TS

    更新日期:2015-12-01 00:00:00

  • Identification of Key Gene Modules of Neuropathic Pain by Co-Expression Analysis.

    abstract::Neuropathic pain (NP) is a substantial clinical problem causing great injury to people word-widely. Although gene expression analyses had been performed previously, the mechanisms underlying the etiology and development of NP are still poorly understood. To understand the function genes involved in the etiology and de...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26098

    authors: Zhang Y,Wang J,Ji LJ,Li L,Wei M,Zhen S,Wen CC

    更新日期:2017-12-01 00:00:00

  • MicroRNA-410 is involved in mitophagy after cardiac ischemia/reperfusion injury by targeting high-mobility group box 1 protein.

    abstract::Mitochondrial dysfunction has emerged as a critical pathophysiological factor of myocardial ischemia/reperfusion (I/R) injury. A thorough understanding of mitochondrial dysfunction during I/R at the molecular level is urgently needed. One prominent microRNA, miR-410, was previously reported to be dynamically regulated...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26405

    authors: Yang F,Li T,Dong Z,Mi R

    更新日期:2018-02-01 00:00:00