当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer.

Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer.

Abstract：

OBJECTIVE:Heme oxygenase-1 (HO-1) has emerged as a crucial mediator of mucosal defense in the gastrointestinal tract. Its metabolic pathway products, biliverdin/bilirubin and carbon monoxide, can reduce oxidative stress and inflammation, and promote resistance to apoptosis. The role of HO-1 in gastrointestinal malignancies, however, remains to be elucidated. The purpose of this study was to analyze HO-1 expression in human colon adenoma and cancer samples. MATERIAL AND METHODS:Fifty-five paraffin-embedded surgical specimens of colorectal cancer and 19 colonic adenoma samples were stained immunhistochemically for HO-1 expression using an anti-HO-1 monoclonal antibody. HO-1 expression was evaluated independently by two different investigators and subsequently correlated to clinical data and patients' life expectancy. RESULTS:Focal HO-1 expression could be documented in 41.8% (23/55) of patients with colorectal cancer. HO-1 expression in colonic adenoma was detectable in 36.8% (7/19) of cases. The rate of lymphatic tumor invasion was significantly lower in colorectal cancer samples expressing HO-1 (p=0.048). Additionally, fewer lymph node metastases were found in colorectal cancer samples with HO-1 expression, but these differences did not reach statistical significance. Mean observation period was 65.87+/-3.96 months. Kaplan-Meier analysis showed a significantly better survival for colorectal cancer patients with colonic HO-1 expression (p=0.018). CONCLUSIONS:This study demonstrates that colonic HO-1 may be a prognostic marker of colorectal-cancer outcome.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Becker JC,Fukui H,Imai Y,Sekikawa A,Kimura T,Yamagishi H,Yoshitake N,Pohle T,Domschke W,Fujimori T

doi

10.1080/00365520701192383

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

852-8

issue

7

eissn

0036-5521

issn

1502-7708

pii

779331040

journal_volume

42

pub_type

杂志文章

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