Embryonic undifferentiated cells show scattering activity on a surface coated with immobilized E-cadherin.

Abstract:

:Rearrangement of cell-cell adhesion is a critical event in embryonic development and tissue formation. We investigated the regulatory function of E-cadherin, a key adhesion protein, in the developmental process by using E-cadherin/IgG Fc fusion protein as an adhesion matrix in cell culture. F9 embryonal carcinoma cells usually form colonies when cultured on gelatin or fibronectin matrices. However, F9 cells cultured on the E-cadherin/IgG Fc fusion protein matrix formed a scattered distribution, with a different cytoskeletal organization and E-cadherin-rich protrusions that were regulated by Rac1 activity. The same scattering activity was observed in P19 embryonal carcinoma cells. In contrast, three types of differentiated cells, NMuMG mammary gland cells, MDCK kidney epithelial cells, and mouse primary isolated hepatocytes, did not show the scattering activity observed in F9 and P19 cells. These results suggest that migratory behavior on an E-cadherin-immobilized surface is only observed in embryonic cells, and that the regulatory mechanisms underlying E-cadherin-mediated cell adhesion vary with the state of differentiation.

journal_name

J Cell Biochem

authors

Nagaoka M,Ise H,Harada I,Koshimizu U,Maruyama A,Akaike T

doi

10.1002/jcb.21406

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

296-310

issue

1

eissn

0730-2312

issn

1097-4644

journal_volume

103

pub_type

杂志文章
  • Inhibition of osteoblastic cell differentiation by conditioned medium derived from the human prostatic cancer cell line PC-3 in vitro.

    abstract::Human prostatic carcinoma frequently metastasizes to bone tissue and activates bone metabolism, especially bone formation, at the site of metastasis. It has been reported that an extract of prostatic carcinoma and conditioned medium (CM) of a human prostatic carcinoma cell line, PC-3, established from a bone metastast...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:

    authors: Kido J,Yamauchi N,Ohishi K,Kataoka M,Nishikawa S,Nakamura T,Kadono H,Ikedo D,Ueno A,Nonomura N,Okuyama A,Nagata T

    更新日期:1997-11-01 00:00:00

  • How is Type I procollagen synthesis regulated at the gene level during tissue fibrosis.

    abstract::In response to tissue injury connective tissue synthesis occurs either normally or abnormally, which is mediated by transforming growth factor-beta (TGF-beta) and other growth factors. This article will be primarily concerned with the response of injured tissues at the gene level of Type I procollagen synthesis in res...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.10599

    authors: Cutroneo KR

    更新日期:2003-09-01 00:00:00

  • Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts.

    abstract::Previously we have shown that transforming growth factor beta (TGF beta) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not known. IGFBP-6 b...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19970701)66:1<77::aid-jcb9

    authors: Gabbitas B,Canalis E

    更新日期:1997-07-01 00:00:00

  • Proteomic and redox-proteomic evaluation of homogentisic acid and ascorbic acid effects on human articular chondrocytes.

    abstract::Alkaptonuria (AKU) is a rare genetic disease associated with the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues up to the deposition of melanin-like pigments (ochronosis). Since little is known on the effects of HGA and its metabolites on articular cells, we carried...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22780

    authors: Braconi D,Laschi M,Taylor AM,Bernardini G,Spreafico A,Tinti L,Gallagher JA,Santucci A

    更新日期:2010-11-01 00:00:00

  • Caspase inhibition and N6-benzyladenosine-induced apoptosis in HL-60 cells.

    abstract::As an extension of our recently published work (Mlejnek and Kuglík [2000] J. Cell. Biochem. 77:6-17), the role of caspases in N(6)-benzylaminopurine riboside (BAPR)-induced apotosis in HL-60 cells was evaluated in this study. Here, BAPR-induced apoptosis was accompanied by activation of caspase-3 and caspase-9. Howeve...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.1262

    authors: Mlejnek P

    更新日期:2001-01-01 00:00:00

  • Inhibition of mammalian collagenases by thiol-containing peptides.

    abstract::The following thiol-containing peptide analogues of the carboxyl side of the collagenase-sensitive bond of collagen were synthesized and tested as inhibitors of collagenases partially purified from homogenates of rabbit V-2 tumor and culture medium of pig synovium: HSCH2CH(CH3)CO-Ala-OEt (I), HSCH2CH(CH2Ph)CO-Ala-OEt ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240320108

    authors: Gray RD,Miller RB,Spatola AF

    更新日期:1986-01-01 00:00:00

  • Analysis of stable and unstable viral forms in SV40-infected human keratinocytes.

    abstract::We analyzed the state of the genomic DNA of the papovavirus SV40 in human keratinocytes as viral-infected cells gradually acquired a transformed phenotype over time. Initially, the vast majority of the viral DNA is maintained either in a full-length supercoiled form or as truncated subgenomic fragments with little evi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240290205

    authors: Naimski P,Steinberg ML

    更新日期:1985-01-01 00:00:00

  • The perinucleolar compartment.

    abstract::The perinucleolar compartment (PNC) is a distinct nuclear body that localizes to the nucleolar periphery. The PNC is predominantly found in cancer cells, and recent evidence suggests that PNC prevalence can be a pan-cancer marker for tumors of solid tissue origin. The PNC is a heritable structure enriched with newly t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.22107

    authors: Pollock C,Huang S

    更新日期:2009-05-15 00:00:00

  • Downregulation of antidifferentiation noncoding RNA promotes chondrogenic differentiation and calcification of ligamentum flavum-derived mesenchymal stem cells.

    abstract::Ligamentum flavum (LF)-derived mesenchymal stem cells (MSCs) have been implicated in the pathogenesis of calcification of the ligamentum flavum (CLF) leading to the increased presence of chondrocyte-like cells and calcium deposition in CLF; however, the mechanisms of LF-MSCs in differentiation are not defined. In this...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27611

    authors: Zhang Q,Wang S,Sheng Y,Zhao S,Jiang Y,Zhou D,Yang H

    更新日期:2019-03-01 00:00:00

  • Bone morphogenetic proteins in vertebrate hematopoietic development.

    abstract::During embryonic development, the hematopoietic system is the first to generate terminally differentiated, functional cell types. The urgent necessity for the early formation of blood and blood vessels during embryogenesis means that the induction, expansion, and maturation of these systems must be rapidly and precise...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.20191

    authors: Snyder A,Fraser ST,Baron MH

    更新日期:2004-10-01 00:00:00

  • miR-34b Modulates Skeletal Muscle Cell Proliferation and Differentiation.

    abstract::Myogenesis involves myoblast proliferation and differentiation to myocytes, followed by fusion and hypertrophy to form myotubes during muscle development. Increasing evidence showed that microRNAs (miRNAs) play important roles in the regulation of myogenesis. We have previously revealed that miR-34b is steadily increa...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26079

    authors: Tang Z,Qiu H,Luo L,Liu N,Zhong J,Kang K,Gou D

    更新日期:2017-12-01 00:00:00

  • STAT-mediated EGFR signaling in cancer.

    abstract::The epidermal growth factor receptor (EGFR) and signal transducers and activators of transcription (STATs) are commonly expressed and activated in many malignancies. EGFR is an upstream activator of several pathways involved in tumor progression, and STATs activate selected genes involved in oncogenesis. There are sev...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.21475

    authors: Quesnelle KM,Boehm AL,Grandis JR

    更新日期:2007-10-01 00:00:00

  • Upregulation of stanniocalcin-1 inhibits the development of osteoarthritis by inhibiting survival and inflammation of fibroblast-like synovial cells.

    abstract:OBJECTIVE:Osteoarthritis (OA) is a progressive and disabling disorder, characterized by synovial inflammation and joint effusion. This study aimed to explore the role of stanniocalcin-1 (STC1) in the development of OA by regulating the survival and inflammation of fibroblast-like synovial (FLS) cells. METHODS:Microarr...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28257

    authors: Wu Y,Li Z,Jia W,Li M,Tang M

    更新日期:2019-06-01 00:00:00

  • Characterization of female germ-like cells derived from mouse embryonic stem cells through expression of GFP under the control of Figla promoter.

    abstract::Previous studies have demonstrated that germ cells can be derived from mouse embryonic stem cells (ESCs). However, there is still no efficient system, which can visualize the stage of germ cell specification in vitro, and further to identify and enrich germ cells derived from ESCs. Figla (factor in the germline, alpha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24044

    authors: Hu Y,Sun J,Wang J,Wang L,Bai Y,Yu M,Lian Z,Zhang S,Hua J

    更新日期:2012-04-01 00:00:00

  • Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

    abstract::Chylomicrons play a role in atherosclerosis, however, because the mechanisms involved in the cell uptake of these particles are not fully understood, investigations were carried out using a radioactively labeled protein-free triacylglycerol-rich emulsion incubated with peritoneal macrophages obtained from normal and a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10020

    authors: Carvalho MD,Harada LM,Gidlund M,Ketelhuth DF,Boschcov P,Quintão EC

    更新日期:2002-01-01 00:00:00

  • Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrest.

    abstract::Melphalan (MEL) is a chemotherapeutic agent used in breast cancer therapy; however, MEL's side effects limit its clinical applications. In the last 20 years, resveratrol (RSV), a polyphenol found in grape skins, has been proposed to reduce the risk of cancer development. The aim of this study was to investigate whethe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24134

    authors: Casanova F,Quarti J,da Costa DC,Ramos CA,da Silva JL,Fialho E

    更新日期:2012-08-01 00:00:00

  • DNA repair and repair fidelity in metastatic variants of the B16 murine melanoma.

    abstract::We have examined the concept of genomic instability in relation to the metastatic progression of low (F1) and high metastasis (BL6, ML8) clones of the B16 mouse melanoma, by using a mutation assay, and DNA strand break repair and repair fidelity assays. The frequency of induced ouabain resistant colonies between the v...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240510313

    authors: Usmani BA,Lunec J,Sherbet GV

    更新日期:1993-03-01 00:00:00

  • Opposing effects of cyclosporin A and tyrphostin AG-1478 indicate a role for Src protein in the cellular control of mineralization.

    abstract::Cyclosporin A (CsA) induces osteoporosis but not through direct activation of osteoclasts. CsA also inhibits cell-mediated mineralization in marrow stromal cell culture, whereas the tyrphostin AG-1478 increases mineralization. These antagonistic effects on mineralization were used to discern molecules that underwent p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19981001)71:1<116::aid-jcb

    authors: Stekelenburg J,Klein BY,Ben-Bassat H,Rojansky N

    更新日期:1998-10-01 00:00:00

  • Ecto-alkaline phosphatase activity identified at physiological pH range on intact P19 and HL-60 cells is induced by retinoic acid.

    abstract::The activity of membrane-bound alkaline phosphatase (ALP) expressed on the external surface of cultured murine P19 teratocarcinoma and human HL-60 myeloblastic leukemia cells was studied at physiological pH using p-nitrophenylphosphate (pNPP) as substrate. The rate of substrate hydrolysis catalyzed by intact viable ce...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(20000301)76:3<420::aid-jcb

    authors: Scheibe RJ,Kuehl H,Krautwald S,Meissner JD,Mueller WH

    更新日期:2000-01-01 00:00:00

  • Characterization of an Importin alpha/beta-recognized nuclear localization signal in beta-dystroglycan.

    abstract::Beta-dystroglycan (beta-DG) is a widely expressed transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton, and thereby contributing to plasma membrane integrity and signal transduction. We previously observed nuclear localization of beta-DG in cultured cell lines, im...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22581

    authors: Lara-Chacón B,de León MB,Leocadio D,Gómez P,Fuentes-Mera L,Martínez-Vieyra I,Ortega A,Jans DA,Cisneros B

    更新日期:2010-06-01 00:00:00

  • High expression of SGTA in esophageal squamous cell carcinoma correlates with proliferation and poor prognosis.

    abstract::Receptor tyrosine kinases (RTKs) expression and the growth factor such as platelet-derived growth factor (PDGF) and their receptors have been considered relevant in the process of angiogenesis and dissemination in esophageal squamous cell carcinoma (ESCC). Small glutamine-rich tetratricopeptide repeat-containing prote...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24641

    authors: Yang X,Cheng L,Li M,Shi H,Ren H,Ding Z,Liu F,Wang Y,Cheng C

    更新日期:2014-01-01 00:00:00

  • Modulation of O-GlcNAc glycosylation during Xenopus oocyte maturation.

    abstract::O-linked N-acetylglucosamine (O-GlcNAc) glycosylation is a post-translational modification, which is believed antagonises phosphorylation. We have studied the O-GlcNAc level during Xenopus oocyte meiotic resumption, taking advantage of the high synchrony of this model which is dependent upon a burst of phosphorylation...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20242

    authors: Lefebvre T,Baert F,Bodart JF,Flament S,Michalski JC,Vilain JP

    更新日期:2004-11-15 00:00:00

  • Sex-specific effects of estrogen and androgen on gene expression in human monocyte-derived osteoclasts.

    abstract::Estrogen and androgen are both critical for the maintenance of bone, but the target cells, mechanisms, and responses could be sex-specific. To compare sex-specific actions of estrogen and androgen on osteoclasts, human peripheral blood mononuclear precursor cells from adult Caucasian males (n = 3) and females (n = 3) ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.23297

    authors: Wang J,Stern PH

    更新日期:2011-12-01 00:00:00

  • Berberine demonstrates anti-inflammatory properties in Helicobacter pylori-infected mice with chronic gastritis by attenuating the Th17 response triggered by the B cell-activating factor.

    abstract::Berberine (BBR) is an isoquinoline alkaloid derived from various medicinal herbs. Previous studies have suggested that BBR exerts antimicrobial, antitumor, and antidiabetic effects and can be used to treat Helicobacter pylori-induced chronic gastritis. However, the exact mechanism by which BBR inhibits H. pylori infec...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26681

    authors: Wu X,Li X,Dang Z,Jia Y

    更新日期:2018-07-01 00:00:00

  • Calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells.

    abstract::We provided evidence that calcium-calmodulin plays a major role in bradykinin-induced arachidonic acid release by bovine aortic endothelial cells. In cells labeled for 16 hr with 3H-arachidonic acid, ionomycin and Ca2(+)-mobilizing hormones such as bradykinin, thrombin and platelet activating factor induced arachidoni...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4644(19961201)63:3%3C292::AID-J

    authors: Briand SI,Bernier SG,Guillemette G

    更新日期:1996-12-01 00:00:00

  • Wnt/β-catenin signaling enhances transcription of the CX43 gene in murine Sertoli cells.

    abstract::Sertoli cells provide the nutritional and metabolic support for germ cells. Wnt/β-catenin signaling is important for the development of the seminiferous epithelium during embryonic age, although after birth this pathway is downregulated. Cx43 gene codes for a protein that is critical during testicular development. The...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27973

    authors: López C,Aguilar R,Nardocci G,Cereceda K,Vander Stelt K,Slebe JC,Montecino M,Concha II

    更新日期:2019-04-01 00:00:00

  • Role of alpha v beta 5 and alpha v beta 6 integrin glycosylation in the adhesion of a colonic adenocarcinoma cell line (HT29-D4).

    abstract::We have previously characterized the expression of the alpha nu beta 5 and alpha nu beta 6 integrins as major receptors for the human colonic adenocarcinoma cell line (HT29-D4), on vitronectin and fibronectin, respectively [Lehmann et al. (1994): Cancer Res 54:2102-2107]. In the present work we investigated the glycos...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19960501)61:2<266::aid-jcb

    authors: Lehmann M,El Battari A,Abadie B,Martin JM,Marvaldi J

    更新日期:1996-05-01 00:00:00

  • Transcriptional control within the three-dimensional context of nuclear architecture: requirements for boundaries and direction.

    abstract::Evidence is accruing that the architectural organization of nucleic acids and regulatory proteins within the cell nucleus support functional interrelationships between nuclear structure and gene expression. The punctate distribution of several transcription factors has provided several paradigms for pursuing mechanism...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4644(1999)75:32+<24::aid-jcb4>3

    authors: Stein GS,van Wijnen AJ,Stein JL,Lian JB,McNeil S,Pockwinse SM

    更新日期:1999-01-01 00:00:00

  • Upregulated microRNA-194 impairs stemness of cholangiocarcinoma cells through the Rho pathway via inhibition of ECT2.

    abstract::Cholangiocarcinoma (CCA) is devastating for its delayed presence, difficulty in diagnosis, and high mortality. Other studies have supported the important role of microRNAs (miRNAs) in the pathogenesis of CCA, and the role of miR-194 was investigated in several human cancers, though, the molecular mechanism of miR-194 ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29648

    authors: Gao J,Dai C,Yu X,Yin XB,Zhou F

    更新日期:2020-10-01 00:00:00

  • Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes.

    abstract::Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22382

    authors: Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer M

    更新日期:2009-12-15 00:00:00