Abstract:
:The course of intranasal infection of Sendai virus in CBA and DBA mice was investigated in animals decomplemented with purified cobra venom factor. The mice were decomplemented either immediately before inoculation or at 4 days postinfection. Depletion of complement after the infection had been established had no apparent effect on the course of the viral infection in the two strains of mice. In contrast, both strains of mice were protected completely from the lethal effects of an infectious dose of 1 LD50 of virus when the serum C3 levels were depressed by more than 80% during the early stages of infection. The symptoms of morbidity were less pronounced in these animals and there was a delay in the production of hemagglutination-inhibiting antibody. There was no apparent effect on the growth of the virus in lung tissue. The results suggest that the complement system plays a significant pathogenic role during the course of Sendai virus infections in CBA and DBA mice.
journal_name
Can J Microbioljournal_title
Canadian journal of microbiologyauthors
Finnie JC,Aston WP,O'Shaughnessy MV,Stewart RBdoi
10.1139/m82-072subject
Has Abstractpub_date
1982-05-01 00:00:00pages
474-7issue
5eissn
0008-4166issn
1480-3275journal_volume
28pub_type
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