The effect of decomplementation on the infectious course of Sendai virus in mice.

Abstract:

:The course of intranasal infection of Sendai virus in CBA and DBA mice was investigated in animals decomplemented with purified cobra venom factor. The mice were decomplemented either immediately before inoculation or at 4 days postinfection. Depletion of complement after the infection had been established had no apparent effect on the course of the viral infection in the two strains of mice. In contrast, both strains of mice were protected completely from the lethal effects of an infectious dose of 1 LD50 of virus when the serum C3 levels were depressed by more than 80% during the early stages of infection. The symptoms of morbidity were less pronounced in these animals and there was a delay in the production of hemagglutination-inhibiting antibody. There was no apparent effect on the growth of the virus in lung tissue. The results suggest that the complement system plays a significant pathogenic role during the course of Sendai virus infections in CBA and DBA mice.

journal_name

Can J Microbiol

authors

Finnie JC,Aston WP,O'Shaughnessy MV,Stewart RB

doi

10.1139/m82-072

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

474-7

issue

5

eissn

0008-4166

issn

1480-3275

journal_volume

28

pub_type

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