Abstract:
:Lymphoblastoid B.95-8 cells were cultured for four months and three weeks in the presence of increasing concentrations (50--200 microgram/ml) of phosphonoacetic acid (PAA). Several weeks after removal of the PAA, the cultures, in parallel with untreated B.95-8 cells, were tested for the presence of: 1) Epstein-Barr virus (EBV) viral capsid antigen (VCA), and b) transformation of human cord blood lymphocytes. There was no difference in the percentage of cells exhibiting VCA in the B.95-8 PAA treated and untreated cells. However, transformation assays indicated 10 times less transforming virus in culture supernatant harvested from B.95-8 cultures treated with PAA, as compared with the control cultures. Electron microscopic studies indicated the presence of virus particles in B.95-8 control cells and their almost complete absence in the PAA-treated cells.
journal_name
J Virol Methodsjournal_title
Journal of virological methodsauthors
Margalith M,Manor D,Goldblum Ndoi
10.1016/0166-0934(80)90052-xsubject
Has Abstractpub_date
1980-01-01 00:00:00pages
349-54issue
6eissn
0166-0934issn
1879-0984pii
0166-0934(80)90052-Xjournal_volume
1pub_type
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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doi:10.1016/0166-0934(91)90119-k
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
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journal_title:Journal of virological methods
pub_type: 杂志文章
doi:10.1016/j.jviromet.2009.04.023
更新日期:2009-09-01 00:00:00
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journal_title:Journal of virological methods
pub_type: 杂志文章
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更新日期:1989-04-01 00:00:00