Abstract：
:Cell therapy was born in 1968 with the first allogeneic transplantation of hematopoietic stem cells for two immune deficiency disorders: the Wiskott-Aldrich syndrome and the Severe Combined ImmunoDeficiency (SCID). From this pioneering experience, thousands of patients affected with inherited or acquired diseases of the hematopoietic system have benefited from this therapeutic approach. Unfortunately, immunologic obstacles, represented by the compatibility in the major histocompatibility HLA system, still dictate today important limitations for a larger therapeutic utilization of hematopoietic stem cells (HSC). In this review, we have summarized the difficulties and the scientific advances leading us to improve the clinical results; the therapeutic research's track for primary immunodeficiencies is also discussed.
journal_name
C R Bioljournal_title
Comptes rendus biologiesauthors
Cavazzana-Calvo M,Dal-Cortivo L,André-Schmutz I,Hacein-Bey Abina S,Fischer Adoi
10.1016/j.crvi.2007.04.003subject
Has Abstractpub_date
2007-06-01 00:00:00pages
538-42issue
6-7eissn
1631-0691issn
1768-3238pii
S1631-0691(07)00159-Xjournal_volume
330pub_type
历史文章,杂志文章,评审abstract：:I here provide some field observations and literature data showing that egg laying site availability could be the main limiting factor for most arboreal gecko population dynamics. Several natural (typhoons, volcanism, sea level variations) or human-mediated habitat modifications (garden openings in forested areas) pro...
journal_title：Comptes rendus biologies
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abstract：:Zearaja chilensis has been reported from Southern Brazil in the Southwest Atlantic (SWA) to northern Chile in the Southeast Pacific (SEP), and it was listed as vulnerable by the IUCN. Recent molecular studies have called into question the conspecificity between specimens from these opposite coasts of South America, wh...
journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
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doi：10.1016/s1631-0691(03)00048-9
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2011.03.010
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2008.01.006
更新日期：2008-04-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.crvi.2005.04.004
更新日期：2005-06-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2010.09.004
更新日期：2010-11-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
doi：10.1016/j.crvi.2007.07.001
更新日期：2007-09-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
doi：10.1016/j.crvi.2012.03.013
更新日期：2012-04-01 00:00:00
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
pub_type： 杂志文章,评审
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Comptes rendus biologies
pub_type： 杂志文章
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