Abstract:
BACKGROUND:Exposure to stressful life events increases the risk of developing a psychotic disorder. Moreover, increased reactivity to stress seems to represent part of the vulnerability for psychosis. This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress. METHOD:A semi-experimental stress exposure paradigm was used in a sample of 306 genotyped young men (aged 19-24 years), in whom measures of psychotic symptoms were obtained at recruitment in the Greek army (exposed condition) and again after 18 months of military training (unexposed condition). RESULTS:Stress exposure at army induction was associated with an increased level of psychotic symptoms. In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025). CONCLUSION:The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Stefanis NC,Henquet C,Avramopoulos D,Smyrnis N,Evdokimidis I,Myin-Germeys I,Stefanis CN,Van Os Jdoi
10.1017/S0033291707001080subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1651-6issue
11eissn
0033-2917issn
1469-8978pii
S0033291707001080journal_volume
37pub_type
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