Endocrine-disrupting chemicals and testicular cancer: a case-control study.

Abstract:

:Environmental factors appear to be important in the etiology of testicular cancer. In this study, the authors identified some risk factors for testicular cancer, paying particular attention to prenatal and early life exposure to endocrine-disrupting chemicals (EDCs). Using a questionnaire, the authors obtained information on male participants' environmental and occupational exposures during adolescence and adulthood. A multivariate logistic regression analysis of 103 cases and 215 controls showed an association between seminoma and nonseminoma and hobby activities that potentially involved the use of EDCs (eg, paints, glues, or solvents). Rural residence during adolescence was associated with all histological types of testicular cancer and with seminoma. No association was found with occupational exposures of the subjects. This study's findings also confirm previously identified risk factors, such as history of cryptorchidism and undescended testicle, high educational level, and low birth weight, and it gives some support to the hypothesis of a possible association between EDC exposures and testicular cancer.

authors

Nori F,Carbone P,Giordano F,Osborn J,Figà-Talamanca I

doi

10.3200/AEOH.61.2.87-95

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

87-95

issue

2

eissn

1933-8244

issn

2154-4700

journal_volume

61

pub_type

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