The Cockayne-Touraine type of dominant dystrophic epidermolysis bullosa--ultrastructural similarities to the Pasini variant.

Abstract:

:Biopsies from the uninvolved skin of 5 patients with the Cockayne-Touraine (CT) type of dystrophic epidermolysis bullosa (DEB) were studied with the electron microscope. Dermal fibrillar bodies were noted in 2 patients and 3 showed basal lamina (BL) duplication or splitting. Discontinuity of the BL with herniation of keratinocyte cytoplasm was present in one patient. These changes, thought previously to be characteristic of the Pasini variant, indicate that abnormalities of the BL may be involved in blister formation in both disease subgroups.

journal_name

Acta Derm Venereol

authors

Oakley CA,Gawkrodger DJ,Ross JA,Hunter JA

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

253-6

issue

3

eissn

0001-5555

issn

1651-2057

journal_volume

64

pub_type

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