当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study.

The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study.

Abstract：

OBJECTIVES:This study sought to evaluate the associations between different measures of obesity and prevalent atherosclerosis in a large population-based cohort. BACKGROUND:Although obesity is associated with cardiovascular mortality, it is unclear whether this relationship is mediated by increased atherosclerotic burden. METHODS:Using data from the Dallas Heart Study, we assessed the association between gender-specific obesity measures (i.e., body mass index [BMI]; waist circumference [WC]; waist-to-hip ratio [WHR]) and prevalent atherosclerosis defined as coronary artery calcium (CAC) score >10 Agatston units measured by electron-beam computed tomography and detectable aortic plaque measured by magnetic resonance imaging. RESULTS:In univariable analyses (n = 2,744), CAC prevalence was significantly greater only in the fifth versus first quintile of BMI, whereas it increased stepwise across quintiles of WC and WHR (p trend <0.001 for each). After multivariable adjustment for standard risk factors, prevalent CAC was more frequent in the fifth versus first quintile of WHR (odds ratio 1.91, 95% confidence interval 1.30 to 2.80), whereas no independent positive association was observed for BMI or WC. Similar results were observed for aortic plaque in both univariable and multivariable-adjusted analyses. The c-statistic for discrimination of prevalent CAC was greater for WHR compared with BMI and WC in women and men (p < 0.001 vs. BMI; p < 0.01 vs. WC). CONCLUSIONS:We discovered that WHR was independently associated with prevalent atherosclerosis and provided better discrimination than either BMI or WC. The associations between obesity measurements and atherosclerosis mirror those observed between obesity and cardiovascular mortality, suggesting that obesity contributes to cardiovascular mortality via increased atherosclerotic burden.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

See R,Abdullah SM,McGuire DK,Khera A,Patel MJ,Lindsey JB,Grundy SM,de Lemos JA

doi

10.1016/j.jacc.2007.04.066

subject

Has Abstract

pub_date

2007-08-21 00:00:00

pages

752-9

issue

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(07)01761-5

journal_volume

pub_type

杂志文章

在线工具

The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study.