Abstract：
:The aim of this study was to evaluate the biological behaviour of porous scaffold structures of Bonelike which is suitable for either direct clinical use or tissue engineering applications. Porous cylindrical specimens 8x10mm were implanted in the lateral aspect of the tibia of 13 patients (mean age 54 years), during osteotomy surgery for the treatment of medial compartment osteoarthritis of the knee. Implanted cylinders were retrieved at the same time as the removal of the blade plates at 3, 6, 9 and 12 months. Scanning electron microscopy and histological evaluations were performed to observe the biological responses of human bone tissue to porous Bonelike. The penetration depth was determined for all implantation periods, and after 6 months it was already possible to see new bone in the centre of the implanted cylinders, which gives 100% of penetration depth for all implantations periods except for 3 months when bone could only be seen in the peripherical region. Regarding the percentage of the area covered by new bone calculated from two-dimensional histological sections, values of 53+/-15, 76+/-12 and 88+/-9% were achieved for 6, 9 and 12 months, respectively. Due to its structural features porous Bonelike permitted effective vascularization and bone ingrowth, and therefore was fully osteointegrated as shown in the histological surveys. A slow biomaterial degradation with implantation time is envisaged since the material has displayed surface degradation. Bonelike scaffolds show potential for complete ingrowth of osseous tissue and restoration of vascularization throughout the defected site.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Gutierres M,Lopes MA,Sooraj Hussain N,Lemos AF,Ferreira JM,Afonso A,Cabral AT,Almeida L,Santos JDdoi
10.1016/j.actbio.2007.06.009subject
Has Abstractpub_date
2008-03-01 00:00:00pages
370-7issue
2eissn
1742-7061issn
1878-7568pii
S1742-7061(07)00100-6journal_volume
4pub_type
临床试验,杂志文章abstract：:Polymeric ultra-thin films (nanosheets) possess unique properties that make them suitable materials for various biomedical applications. In our previous study, we assessed the use of an antibiotic (tetracycline, TC)-loaded nanosheet (or "TC-nanosheet") for the treatment of gastrointestinal tissue defects. The nanoshee...
journal_title：Acta biomaterialia
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更新日期：2012-08-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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更新日期：2016-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2017-12-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2013.02.046
更新日期：2013-07-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2007.08.001
更新日期：2008-01-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2016.10.018
更新日期：2017-01-15 00:00:00
abstract：UNLABELLED:Chondrocyte dedifferentiation presents a major barrier in engineering functional cartilage constructs. To mitigate the effects of dedifferentiation, this study employed a post-expansion aggregate culture step to enhance the chondrogenic phenotype of passaged articular chondrocytes (ACs) before their integrat...
journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2016.07.044
更新日期：2016-10-01 00:00:00
abstract：:The crossed lamellar microstructure of mollusk shells shows a very complex hierarchical architecture constituted of long rod-shaped aragonite crystals stacked parallel to each other inside each first order lamella, which are almost perpendicular to the ones contained in parallel neighboring lamellae. To better underst...
journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2011.11.001
更新日期：2012-02-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2010.10.024
更新日期：2011-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
abstract：:Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironm...
journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2018-10-15 00:00:00
abstract：:The interactions of cells with synthetic surfaces are a critical factor in biomaterials design and it would be invaluable if these interactions could be precisely controlled and predicted. Hydrophobicity or lipophilicity of the surface is commonly used to rationalize cell attachment to materials. In the pharmaceutical...
journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2007.02.006
更新日期：2007-09-01 00:00:00
