Neuropharmacology of buspirone.

Abstract:

:Buspirone is a clinically effective anxiolytic with a unique structure and pharmacology which distinguishes it from the benzodiazepines. It has been termed anxioselective because it lacks anticonvulsant, sedative, or muscle-relaxant properties. Preclinical evidence suggests it lacks potential for abuse or physical dependence and interacts minimally with CNS depressants such as alcohol. Rather than working through traditional benzodiazepine mechanisms, buspirone affects diverse aspects of the brain's neurochemical circuitry. For example, it exerts potent influences on the nigrostriatal and mesolimbic dopamine systems, the dorsal raphe serotonergic system, and the locus coeruleus noradrenergic system. Although without direct receptor interaction, potentiation of cholinergically mediated behavior and involvement with GABAergic neurotransmission have also been demonstrated.

journal_name

Psychopathology

journal_title

Psychopathology

authors

Riblet LA,Eison AS,Eison MS,Taylor DP,Temple DL,VanderMaelen CP

doi

10.1159/000284133

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

69-78

eissn

0254-4962

issn

1423-033X

journal_volume

17 Suppl 3

pub_type

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