Abstract:
:The supertwisted, double-stranded, replicative intermediate of øX174 DNA (RFI) has been used to determine whether one of the two strands of the double helix is uniquely sensitive to induction of single-strand breaks by ionizing radiation. This could result from a particularly sensitive base sequence or a transfer of energy to a specific location of the DNA molecule. The results indicate that both strands of the double helix are equally broken, even though their base compositions are significantly different. If there are "hot spots" in the strands, then they are present in equal amounts in each strand.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Achey PM,Courtney DGdoi
10.1016/s0006-3495(73)85970-3subject
Has Abstractpub_date
1973-01-01 00:00:00pages
72-9issue
1eissn
0006-3495issn
1542-0086pii
S0006-3495(73)85970-3journal_volume
13pub_type
杂志文章abstract::The investigation of the mechanism of protein folding is complicated by the context dependence of the rates of intramolecular contact formation. Methods based on site-specific labeling and ultrafast spectroscopic detection of fluorescence signals were developed for monitoring the rates of individual subdomain folding ...
journal_title:Biophysical journal
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-03-14 00:00:00
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journal_title:Biophysical journal
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journal_title:Biophysical journal
pub_type: 杂志文章
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:1977-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
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更新日期:2007-09-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1529/biophysj.106.101741
更新日期:2007-05-15 00:00:00
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journal_title:Biophysical journal
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