The effect of delta1-tetrahydrocannabinol on the uptake of [3H]-(minus)-noradrenaline by the isolated perfused heart of the rat.

Abstract:

:Forty-eight isolated rat hearts were perfused with Krebs solution and with [(3)H]-(-)-noradrenaline ([(3)H]-NA) containing 4.5 nCi/ml in 50 ng/ml, as described by Iversen (1963). To groups of six, cocaine was added to [(3)H]-NA in concentrations of 400 nM, 2 and 10 muM. To the rest Tween 80, 25 mug/ml was added to [(3)H]-NA and in three groups Delta(1)-THC additionally in concentrations of 560 nM and 2.8 or 14 muM. Cocaine caused a linear concentration-related inhibition of uptake; Tween caused a 38.7% inhibition; THC caused additionally a linear concentration-related inhibition.

journal_name

Br J Pharmacol

authors

Graham JD,Lewis MJ,Li DM

doi

10.1111/j.1476-5381.1974.tb10686.x

subject

Has Abstract

pub_date

1974-07-01 00:00:00

pages

465-6

issue

3

eissn

0007-1188

issn

1476-5381

journal_volume

51

pub_type

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