NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.

abstract：:Amygdala activation is known to be critical for the processing of stressful events in brain. Recent studies have shown that the projection neurons (PNs) in amygdala, although architecturally intermingled, are integrated into distinct microcircuits and thus play divergent roles in amygdala-related behaviors. It remains...

journal_title：Molecular brain

authors： Song C,Zhang WH,Wang XH,Zhang JY,Tian XL,Yin XP,Pan BX

更新日期：2017-01-09 00:00:00

abstract：BACKGROUND:The metabotropic glutamate receptor 5 (mGluR5) is involved in various brain functions, including memory, cognition and motor behavior. Regarding locomotor activity, we and others have demonstrated that pharmacological antagonism of mGluR5 promotes hyperkinesia in mice. Moreover, increased locomotor activity ...

journal_title：Molecular brain

authors： Guimaraes IM,Carvalho TG,Ferguson SS,Pereira GS,Ribeiro FM

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Aggregation of malformed proteins is a key feature of many neurodegenerative diseases, but the mechanisms that drive proteinopathy in the brain are poorly understood. We aimed to characterize aggregated proteins in human brain tissues affected by dementia. RESULTS:To characterize amyloidal plaque purified f...

journal_title：Molecular brain

authors： Adav SS,Gallart-Palau X,Tan KH,Lim SK,Tam JP,Sze SK

更新日期：2016-02-19 00:00:00

abstract：:FKBP5 encodes the FK506 binding protein 5, a glucocorticoid receptor (GR) binding protein known to play an important role in the physiological stress response. However, results from previous studies examining the association between common variants of FKBP5 and stress have been inconsistent. To investigate whether the...

journal_title：Molecular brain

authors： Kwon J,Kim YJ,Choi K,Seol S,Kang HJ

更新日期：2019-11-27 00:00:00

abstract：:Zinc dyshomeostasis has been recognized as an important mechanism for cell death in acute brain injury. An increase in the level of free or histochemically reactive zinc in astrocytes and neurons is considered one of the major causes of death of these cells in ischemia and trauma. Although zinc dyshomeostasis can lead...

journal_title：Molecular brain

authors： Lee SJ,Koh JY

更新日期：2010-10-26 00:00:00

abstract：:Disrupted GABAergic neurons have been extensively described in brain tissues from individuals with autism spectrum disorder (ASD) and animal models for ASD. However, the contribution of these aberrant inhibitory neurons to autism-related behavioral phenotypes is not well understood. We examined ASD-related behaviors i...

journal_title：Molecular brain

authors： Shin S,Santi A,Huang S

更新日期：2021-01-27 00:00:00

abstract：:The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety level. The 5-HT1A and 2A receptors are widely expressed across the brain, but th...

journal_title：Molecular brain

authors： Ju A,Fernandez-Arroyo B,Wu Y,Jacky D,Beyeler A

更新日期：2020-06-29 00:00:00

abstract：:The human immunodeficiency virus (HIV) is a neurotropic virus. It induces neurotoxicity and subsequent brain pathologies in different brain cells. Addiction to recreational drugs remarkably affects the initiation of HIV infections and expedites the progression of acquired immunodeficiency syndrome (AIDS) associated ne...

journal_title：Molecular brain

authors： Sagar V,Atluri VS,Pilakka-Kanthikeel S,Nair M

更新日期：2016-05-23 00:00:00

abstract：:The alpha-isoform of calcium/calmodulin-dependent kinase II (αCaMKII) is a major synaptic kinase that undergoes autophosphorylation after NMDA receptor activation, switching the kinase into a calcium-independent activity state. This αCaMKII autophosphorylation is essential for NMDA receptor-dependent long-term potenti...

journal_title：Molecular brain

authors： Irvine EE,Danhiez A,Radwanska K,Nassim C,Lucchesi W,Godaux E,Ris L,Giese KP

更新日期：2011-01-28 00:00:00

abstract：:The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult rats was occluded for 2 h...

journal_title：Molecular brain

authors： Choi KH,Park MS,Kim HS,Kim KT,Kim HS,Kim JT,Kim BC,Kim MK,Park JT,Cho KH

更新日期：2015-02-11 00:00:00

abstract：BACKGROUND:Group I metabotropic glutamate receptors (mGlu1/5 receptors) have important roles in synaptic activity in the central nervous system. They modulate neuronal excitability by mobilizing intracellular Ca2+ following receptor activation. Also, accumulating evidence has indicated the association of Ca2+ signaling...

journal_title：Molecular brain

authors： Roh SE,Hong YH,Jang DC,Kim J,Kim SJ

更新日期：2014-02-10 00:00:00

abstract：:The temporal organization of activity/rest or sleep/wake rhythms for mammals is regulated by the interaction of light/dark cycle and circadian clocks. The neural and molecular mechanisms that confine the active phase to either day or night period for the diurnal and the nocturnal mammals are unclear. Here we report th...

journal_title：Molecular brain

authors： Zhou QY,Burton KJ,Neal ML,Qiao Y,Kanthasamy AG,Sun Y,Xu X,Ma Y,Li X

更新日期：2016-08-18 00:00:00

abstract：:Neuropathic pain is generally defined as a chronic pain state resulting from peripheral and/or central nerve injury. Effective treatment for neuropathic pain is still lacking, due in part to poor understanding of pathological mechanisms at the molecular level. Neuronal mechanisms of neuropathic pain, especially synapt...

journal_title：Molecular brain

authors： Zhuo M,Wu G,Wu LJ

更新日期：2011-07-30 00:00:00

abstract：:Mutations in protocadherin 19 (PCDH19), which is on the X-chromosome, cause the brain disease Epilepsy in Females with Mental Retardation (EFMR). EFMR is also often associated with autism-like symptoms. In mice and humans, epilepsy occurs only in heterozygous females who have a mixture of PCDH19 wild-type (WT) and mut...

journal_title：Molecular brain

authors： Lim J,Ryu J,Kang S,Noh HJ,Kim CH

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:A loss of function of the L-type calcium channel, Cav1.2, results in a cardiac specific disease known as Brugada syndrome. Although many Brugada syndrome channelopathies reduce channel function, one point mutation in the N-terminus of Cav1.2 (A39V) has been shown to elicit disease a phenotype because of a lo...

journal_title：Molecular brain

authors： Simms BA,Zamponi GW

更新日期：2012-03-02 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this factor remain unknown. Here, we show that MIF increases the expression of Pax6 and Chd7 in NSPCs in vitro. Durin...

journal_title：Molecular brain

authors： Ohta S,Yaguchi T,Okuno H,Chneiweiss H,Kawakami Y,Okano H

更新日期：2016-12-13 00:00:00

abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors. Owing to the difficulty of clinical diagnosis, ASD without intellectual disability (i.e., high-functioning ASD) is often overlooked. MicroRNAs (miRNAs) have been recently recognized ...

journal_title：Molecular brain

authors： Nakata M,Kimura R,Funabiki Y,Awaya T,Murai T,Hagiwara M

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:Dendrites of retinal ganglion cells (RGCs) synapse with axon terminals of bipolar cells in the inner plexiform layer (IPL). Changes in RGC dendrites and synapses between bipolar cells in the inner retinal layer may critically alter the function of RGCs in glaucoma. Recently, synaptic plasticity has been obse...

journal_title：Molecular brain

authors： Park HY,Kim JH,Park CK

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Wnt5a, originally identified as a guidance cue for commissural axons, activates a non-canonical pathway critical for cortical axonal morphogenesis. The molecular signaling cascade underlying this event remains obscure. RESULTS:Through Ca(2+) imaging in acute embryonic cortical slices, we tested if radially ...

journal_title：Molecular brain

authors： Horigane S,Ageta-Ishihara N,Kamijo S,Fujii H,Okamura M,Kinoshita M,Takemoto-Kimura S,Bito H

更新日期：2016-01-16 00:00:00

abstract：:Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), a DNA/RNA binding protein, is a pathological signature of amyotrophic lateral sclerosis (ALS). Missense mutations in the TARDBP gene are also found in inherited and sporadic ALS, indicating that dysfunction in TDP-43 is causative for ALS. To model TDP-43-li...

journal_title：Molecular brain

authors： Watanabe S,Oiwa K,Murata Y,Komine O,Sobue A,Endo F,Takahashi E,Yamanaka K

更新日期：2020-01-20 00:00:00

abstract：:Irritable bowel syndrome (IBS) is characterized by recurrent abdominal discomfort, spontaneous pain, colorectal hypersensitivity and bowel dysfunction. Patients with IBS also suffer from emotional anxiety and depression. However, few animal studies have investigated IBS-induced spontaneous pain and behavioral anxiety....

journal_title：Molecular brain

authors： Zhang MM,Liu SB,Chen T,Koga K,Zhang T,Li YQ,Zhuo M

更新日期：2014-06-16 00:00:00

abstract：:This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by intraperitoneal injection of lithium chloride-pilocarpine. These model rats were injected intracerebroventricular...

journal_title：Molecular brain

authors： Huang H,Cui G,Tang H,Kong L,Wang X,Cui C,Xiao Q,Ji H

更新日期：2019-12-03 00:00:00

abstract：:Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a Gαi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system including microglia, as well as intestinal and kidney macrophages. Cx3cr1CreERT2 mice express Cre recombina...

journal_title：Molecular brain

authors： Lee Y,Lee JW,Nam H,Yu SW

更新日期：2020-06-08 00:00:00

abstract：:Mossy fibers, the dentate granule cell axons, are generated throughout an animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the stratum lucidum within the CA3 region. Brain-derived neurotrophic factor (BDNF), a neurotrophin family protein that activates Trk neurotrophin receptors, is highly...

journal_title：Molecular brain

authors： Tamura M,Tamura N,Ikeda T,Koyama R,Ikegaya Y,Matsuki N,Yamada MK

更新日期：2009-01-31 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin r...

journal_title：Molecular brain

authors： Yohn CN,Gergues MM,Samuels BA

更新日期：2017-06-24 00:00:00

abstract：:Paranodal axoglial junctions are essential for rapid nerve conduction and the organization of axonal domains in myelinated axons. Neurofascin155 (Nfasc155) is a glial cell adhesion molecule that is also required for the assembly of these domains. Previous studies have demonstrated that general ablation of Nfasc155 dis...

journal_title：Molecular brain

authors： Kunisawa K,Hatanaka N,Shimizu T,Kobayashi K,Osanai Y,Mouri A,Shi Q,Bhat MA,Nambu A,Ikenaka K

更新日期：2020-11-23 00:00:00

abstract：:PERK (EIF2AK3) is an ER-resident eIF2α kinase required for behavioral flexibility and metabotropic glutamate receptor-dependent long-term depression via its translational control. Motivated by the recent discoveries that PERK regulates Ca2+ dynamics in insulin-secreting β-cells underlying glucose-stimulated insulin se...

journal_title：Molecular brain

authors： Zhu S,McGrath BC,Bai Y,Tang X,Cavener DR

更新日期：2016-10-01 00:00:00

abstract：:We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a functional magnetic resonance imaging scanner. In the bodily imagery task, participants were instructed to imagi...

journal_title：Molecular brain

authors： Jung WM,Lee YS,Lee IS,Wallraven C,Ryu Y,Chae Y

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:A converging body of evidence indicates that levels of adult hippocampal neurogenesis vary along the septo-temporal axis of the dentate gyrus, but the molecular mechanisms underlying this regional heterogeneity are not known. We previously identified a niche mechanism regulating proliferation and neuronal de...

journal_title：Molecular brain

authors： Sun J,Bonaguidi MA,Jun H,Guo JU,Sun GJ,Will B,Yang Z,Jang MH,Song H,Ming GL,Christian KM

更新日期：2015-09-04 00:00:00

abstract：:To prevent or ameliorate Alzheimer's disease (AD) we must understand its molecular basis. AD develops over decades but detailed molecular analysis of AD brains is limited to postmortem tissue where the stresses initiating the disease may be obscured by compensatory responses and neurodegenerative processes. Rare, domi...

journal_title：Molecular brain

authors： Newman M,Hin N,Pederson S,Lardelli M

更新日期：2019-05-03 00:00:00