NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.

abstract：:Mossy fibers, the dentate granule cell axons, are generated throughout an animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the stratum lucidum within the CA3 region. Brain-derived neurotrophic factor (BDNF), a neurotrophin family protein that activates Trk neurotrophin receptors, is highly...

journal_title：Molecular brain

authors： Tamura M,Tamura N,Ikeda T,Koyama R,Ikegaya Y,Matsuki N,Yamada MK

更新日期：2009-01-31 00:00:00

abstract：:Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel activity. Previous studies have documented the importance of asparagine (N)-linked glycosylation and identified...

journal_title：Molecular brain

authors： Ficelova V,Souza IA,Cmarko L,Gandini MA,Stringer RN,Zamponi GW,Weiss N

更新日期：2020-11-11 00:00:00

abstract：:The anterior cingulate cortex (ACC) is involved in sensory, cognitive, and executive functions. Studies of synaptic transmission and plasticity in the ACC provide an understanding of basic cellular and molecular mechanisms for brain functions. Previous anatomic studies suggest complex local interactions among neurons ...

journal_title：Molecular brain

authors： Wu LJ,Li X,Chen T,Ren M,Zhuo M

更新日期：2009-10-15 00:00:00

abstract：:Parkinson's disease (PD), classically defined as a progressive motor disorder accompanied with dopaminergic neuron loss and presence of Lewy bodies, is the second most common neurodegenerative disease. PD also has various non-classical symptoms, including cognitive impairments. In addition, inflammation and astroglios...

journal_title：Molecular brain

authors： Stanojlovic M,Pallais JP,Lee MK,Kotz CM

更新日期：2019-10-30 00:00:00

abstract：:The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs during this developmental window, it is important to determine whether anesthesia-induced apoptosis targets the same cell population as physiological ...

journal_title：Molecular brain

authors： Wang Q,Shen FY,Zou R,Zheng JJ,Yu X,Wang YW

更新日期：2017-06-17 00:00:00

abstract：:In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models, the added feature of hydrocephalus. We observed increased Glial Fibrillary Acidic Protein (GFAP) immunoreacti...

journal_title：Molecular brain

authors： Singh M,Garrison JE,Wang K,Sheffield VC

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Group I metabotropic glutamate receptors (mGlu1/5 receptors) have important roles in synaptic activity in the central nervous system. They modulate neuronal excitability by mobilizing intracellular Ca2+ following receptor activation. Also, accumulating evidence has indicated the association of Ca2+ signaling...

journal_title：Molecular brain

authors： Roh SE,Hong YH,Jang DC,Kim J,Kim SJ

更新日期：2014-02-10 00:00:00

abstract：BACKGROUND:p21-activated kinase 1 (PAK1) is a serine/threonine kinase known to be activated by the Rho family small GTPases and to play a key role in cytoskeletal reorganization, spine morphology and synaptic plasticity. PAK1 is also implicated in a number of neurodevelopmental and neurodegenerative diseases, including...

journal_title：Molecular brain

authors： Pan X,Chang X,Leung C,Zhou Z,Cao F,Xie W,Jia Z

更新日期：2015-06-05 00:00:00

abstract：:The ventral tegmental area (VTA) is one of the main brain regions harboring dopaminergic (DA) neurons, and plays important roles in reinforcement and motivation. Recent studies have indicated that DA neurons not only respond to rewarding stimuli, but also to noxious stimuli. Furthermore, VTA DA neurons undergo plastic...

journal_title：Molecular brain

authors： Huang S,Borgland SL,Zamponi GW

更新日期：2019-11-04 00:00:00

abstract：:Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region. CNVs are greater than 1 kb in size; hence, CNVs can produce more variation than can ind...

journal_title：Molecular brain

authors： Hama Y,Katsu M,Takigawa I,Yabe I,Matsushima M,Takahashi I,Katayama T,Utsumi J,Sasaki H

更新日期：2017-11-29 00:00:00

abstract：BACKGROUND:Agonist stimulation of Group I metabotropic glutamate receptors (mGluRs) initiates their coupling to the heterotrimeric G protein, Gαq/11, resulting in the activation of phospholipase C, the release of Ca(2+) from intracellular stores and the subsequent activation of protein kinase C. However, it is now reco...

journal_title：Molecular brain

authors： Raka F,Di Sebastiano AR,Kulhawy SC,Ribeiro FM,Godin CM,Caetano FA,Angers S,Ferguson SS

更新日期：2015-03-26 00:00:00

abstract：:This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore the related regulatory mechanisms. A rat model of TLE was established by intraperitoneal injection of lithium chloride-pilocarpine. These model rats were injected intracerebroventricular...

journal_title：Molecular brain

authors： Huang H,Cui G,Tang H,Kong L,Wang X,Cui C,Xiao Q,Ji H

更新日期：2019-12-03 00:00:00

abstract：:Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in the VPS35 gene have been identified in patients with autosomal dominant Parkinson's disease (PD). However, it r...

journal_title：Molecular brain

authors： Vanan S,Zeng X,Chia SY,Varnäs K,Jiang M,Zhang K,Saw WT,Padmanabhan P,Yu WP,Zhou ZD,Halldin C,Gulyás B,Tan EK,Zeng L

更新日期：2020-12-01 00:00:00

abstract：:Disrupted GABAergic neurons have been extensively described in brain tissues from individuals with autism spectrum disorder (ASD) and animal models for ASD. However, the contribution of these aberrant inhibitory neurons to autism-related behavioral phenotypes is not well understood. We examined ASD-related behaviors i...

journal_title：Molecular brain

authors： Shin S,Santi A,Huang S

更新日期：2021-01-27 00:00:00

abstract：:Electroconvulsive therapy (ECT) is a highly effective and fast-acting treatment for depression. Despite a long history of clinical use, its mechanism of action remains poorly understood. Recently, a novel cellular mechanism of antidepressant action has been proposed: the phenotype of mature brain neurons is transforme...

journal_title：Molecular brain

authors： Imoto Y,Segi-Nishida E,Suzuki H,Kobayashi K

更新日期：2017-03-02 00:00:00

abstract：:The alpha-isoform of calcium/calmodulin-dependent kinase II (αCaMKII) is a major synaptic kinase that undergoes autophosphorylation after NMDA receptor activation, switching the kinase into a calcium-independent activity state. This αCaMKII autophosphorylation is essential for NMDA receptor-dependent long-term potenti...

journal_title：Molecular brain

authors： Irvine EE,Danhiez A,Radwanska K,Nassim C,Lucchesi W,Godaux E,Ris L,Giese KP

更新日期：2011-01-28 00:00:00

abstract：:We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a functional magnetic resonance imaging scanner. In the bodily imagery task, participants were instructed to imagi...

journal_title：Molecular brain

authors： Jung WM,Lee YS,Lee IS,Wallraven C,Ryu Y,Chae Y

更新日期：2020-11-23 00:00:00

abstract：:Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism is unclear, and treatment is challenging. The analgesic effect of N-methyl-D-aspartate (NMDA) receptor antagonists and the morphine-associated increase in NMDA receptor activation suggest potential role of NMDA rec...

journal_title：Molecular brain

authors： Shen L,Wang W,Li S,Qin J,Huang Y

更新日期：2018-06-28 00:00:00

abstract：:CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 mutation manifest myelination defects and ASD-like behaviors, the detailed mechanisms underlying ASD pathogenes...

journal_title：Molecular brain

authors： Kawamura A,Abe Y,Seki F,Katayama Y,Nishiyama M,Takata N,Tanaka KF,Okano H,Nakayama KI

更新日期：2020-11-23 00:00:00

abstract：:Memories are stored within neuronal ensembles in the brain. Modern genetic techniques can be used to not only visualize specific neuronal ensembles that encode memories (e.g., fear, craving) but also to selectively manipulate those neurons. These techniques are now being expanded for the study of various types of memo...

journal_title：Molecular brain

authors： Sakaguchi M,Hayashi Y

更新日期：2012-09-21 00:00:00

abstract：:Neuropathic pain is generally defined as a chronic pain state resulting from peripheral and/or central nerve injury. Effective treatment for neuropathic pain is still lacking, due in part to poor understanding of pathological mechanisms at the molecular level. Neuronal mechanisms of neuropathic pain, especially synapt...

journal_title：Molecular brain

authors： Zhuo M,Wu G,Wu LJ

更新日期：2011-07-30 00:00:00

abstract：BACKGROUND:To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 regi...

journal_title：Molecular brain

authors： Motolese M,Mastroiacovo F,Cannella M,Bucci D,Gaglione A,Riozzi B,Lütjens R,Poli SM,Celanire S,Bruno V,Battaglia G,Nicoletti F

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Dendrites of retinal ganglion cells (RGCs) synapse with axon terminals of bipolar cells in the inner plexiform layer (IPL). Changes in RGC dendrites and synapses between bipolar cells in the inner retinal layer may critically alter the function of RGCs in glaucoma. Recently, synaptic plasticity has been obse...

journal_title：Molecular brain

authors： Park HY,Kim JH,Park CK

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:The metabotropic glutamate receptor 5 (mGluR5) is involved in various brain functions, including memory, cognition and motor behavior. Regarding locomotor activity, we and others have demonstrated that pharmacological antagonism of mGluR5 promotes hyperkinesia in mice. Moreover, increased locomotor activity ...

journal_title：Molecular brain

authors： Guimaraes IM,Carvalho TG,Ferguson SS,Pereira GS,Ribeiro FM

更新日期：2015-04-10 00:00:00

abstract：:Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of cultured brain circuits to BDNF leads to up-regulation of glutamatergic neuro-transmission, by the accurate tuning of pre and post synaptic features, l...

journal_title：Molecular brain

authors： Rauti R,Cellot G,D'Andrea P,Colliva A,Scaini D,Tongiorgi E,Ballerini L

更新日期：2020-03-17 00:00:00

abstract：:The human immunodeficiency virus (HIV) is a neurotropic virus. It induces neurotoxicity and subsequent brain pathologies in different brain cells. Addiction to recreational drugs remarkably affects the initiation of HIV infections and expedites the progression of acquired immunodeficiency syndrome (AIDS) associated ne...

journal_title：Molecular brain

authors： Sagar V,Atluri VS,Pilakka-Kanthikeel S,Nair M

更新日期：2016-05-23 00:00:00

abstract：:FKBP5 encodes the FK506 binding protein 5, a glucocorticoid receptor (GR) binding protein known to play an important role in the physiological stress response. However, results from previous studies examining the association between common variants of FKBP5 and stress have been inconsistent. To investigate whether the...

journal_title：Molecular brain

authors： Kwon J,Kim YJ,Choi K,Seol S,Kang HJ

更新日期：2019-11-27 00:00:00

abstract：:Mutations in protocadherin 19 (PCDH19), which is on the X-chromosome, cause the brain disease Epilepsy in Females with Mental Retardation (EFMR). EFMR is also often associated with autism-like symptoms. In mice and humans, epilepsy occurs only in heterozygous females who have a mixture of PCDH19 wild-type (WT) and mut...

journal_title：Molecular brain

authors： Lim J,Ryu J,Kang S,Noh HJ,Kim CH

更新日期：2019-11-20 00:00:00

abstract：:Selective attention modulates sensory cortical activity. It remains unclear how auditory cortical activity represents stimuli that differ behaviorally. We designed a cross-modality task in which mice made decisions to obtain rewards based on attended visual or auditory stimuli. We recorded auditory cortical activity i...

journal_title：Molecular brain

authors： Yao PT,Shen J,Chen L,Ge S,Xiong Q

更新日期：2019-10-17 00:00:00

abstract：:Cav3.2 T-type calcium channels are important mediators of nociceptive signaling, but their roles in the transmission of itch remains poorly understood. Here we report a key involvement of these channels as key modulators of itch/pruritus-related behavior. We compared scratching behavior responses between wild type and...

journal_title：Molecular brain

authors： Gadotti VM,Kreitinger JM,Wageling NB,Budke D,Diaz P,Zamponi GW

更新日期：2020-09-01 00:00:00