Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs.

abstract：:Serum factors activating the alternative pathway of complement in vitro, independent of classical pathway activation was demonstrated in six of eleven patients with systemic lupus erythematosus (SLE). These serum factors were detected by lysis of gluthathione-sensitized human erythrocytes and by C3 and factor B conver...

journal_title：Clinical and experimental immunology

authors： Wilson MR,Arroyave CM,Nakamura RM,Vaughan JH,Tan EM

更新日期：1976-10-01 00:00:00

abstract：:In rheumatoid arthritis (RA) there are currently no good indicators to predict a clinical response to rituximab. The purpose of this study was to monitor and determine the role of peripheral blood cytokine profiling in differentiating between a good versus poor response to rituximab in RA. Blood samples were collected...

journal_title：Clinical and experimental immunology

authors： Fabre S,Guisset C,Tatem L,Dossat N,Dupuy AM,Cohen JD,Cristol JP,Daures JP,Jorgensen C

更新日期：2009-03-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) of normal human donors are spontaneously cytotoxic for certain tumour-derived and virus-infected target cells. This so-called natural killing (NK) can be augmented by the action of interferons (IFN) and by IFN-inducers. In this study, we have compared both endogenous and augme...

journal_title：Clinical and experimental immunology

authors： Neighbour PA,Grayzel AI,Miller AE

更新日期：1982-07-01 00:00:00

abstract：:Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. U...

journal_title：Clinical and experimental immunology

authors： D'Arrigo C,Candal-Couto JJ,Greer M,Veale DJ,Woof JM

更新日期：1995-04-01 00:00:00

abstract：:Mixtures of serum of Freund's complete adjuvant (FCA) immunized guinea-pigs and tuberculin PPD consistently inhibited the in vitro migration of peritoneal exudate cells (PEC) of normal guinea-pigs. It is shown that this inhibitory effect is due to a soluble complex between an IgG2 antibody and PPD. By separation of PP...

journal_title：Clinical and experimental immunology

authors： Kotkes P,Pick E

更新日期：1975-01-01 00:00:00

abstract：:Chlorazole fast pink 2BL inhibited the classical complement pathway in rat serum both in vivo and in vitro. The in vitro potency of chlorazole fast pink against the alternative pathway could not be assessed accurately but it was clearly less than that against the classical pathway. The compound appears to bind strongl...

journal_title：Clinical and experimental immunology

authors： Doherty NS

更新日期：1981-02-01 00:00:00

abstract：:Previous studies have shown that neutralization of macrophage migration inhibitory factor (MIF) by anti-MIF antibody reduces intestinal inflammation in mice. In this study we tested whether or not anti-MIF autoantibody induced by DNA vaccine targeting MIF protects mice against experimental colitis. Mice were administe...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Koyama Y,Onodera S,Takeda H,Kato M,Asaka M,Nishihira J

更新日期：2011-01-01 00:00:00

abstract：:In this paper, we report the presence on Epstein-Barr virus-transformed lymphoblastoid cell lines on platelets and on fibroblasts of an HLA-B27-associated cell surface complex (antigenically related to some antigens of Klebsiella K43 and K21) which is identical to or cross-reactive with the determinant present on the ...

journal_title：Clinical and experimental immunology

authors： Alexander K,Edwards C,Misko IS,Geczy AF,Bashir HV,Edmonds JP

更新日期：1981-07-01 00:00:00

abstract：:The human immune response to the 10-kD M. tuberculosis protein was studied by a competition ELISA using monoclonal antibody (MoAb) SA-12. Twenty-five per cent of the sera from 20 patients with tuberculosis and none from 21 control subjects inhibited binding of SA-12 to the 10-kD antigen. To characterize the antigenic ...

journal_title：Clinical and experimental immunology

authors： Verbon A,Hartskeerl RA,Kolk AH

更新日期：1991-10-01 00:00:00

abstract：:A more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and in this study sought to determine protein expression of ...

journal_title：Clinical and experimental immunology

authors： Cameron SA,White SM,Arrollo D,Shulman ST,Rowley AH

更新日期：2017-11-01 00:00:00

abstract：:To determine the effect of prolonged administration of exogenous interferon on the autoimmune disease of NZB/W female mice, forty-four NZB/W mice received three injections per week of 6.4 x 10(4) interferon units from birth to 33 weeks, forty mice were injected with mock interferon and forty-eight mice were left untre...

journal_title：Clinical and experimental immunology

authors： Adam C,Thoua Y,Ronco P,Verroust P,Tovey M,Morel-Maroger L

更新日期：1980-05-01 00:00:00

abstract：:Allele variants in the L-carnitine (LCAR) transporters OCTN1 (SLC22A4, 1672 C --> T) and OCTN2 (SLC22A5, -207 G --> C) have been implicated in susceptibility to Crohn's disease (CD). LCAR is consumed in the diet and transported actively from the intestinal lumen via the organic cation transporter OCTN2. While recogniz...

journal_title：Clinical and experimental immunology

authors： Fortin G,Yurchenko K,Collette C,Rubio M,Villani AC,Bitton A,Sarfati M,Franchimont D

更新日期：2009-04-01 00:00:00

abstract：:T cells are thought to play an important regulatory role in atopic asthma. We hypothesized that human blood and BAL T cell subsets bearing various TCR-Vbeta genes might show selective differences in their cytokine profile. Peripheral blood (PB) and bronchoalveolar lavage (BAL) T cells from seven atopic asthmatic and s...

journal_title：Clinical and experimental immunology

authors： Bakakos P,Pickard C,Smith JL,Frew AJ

更新日期：2002-05-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction in SSc is characterized by the activation and recruitment of immune cells and the production of autoantibodies and cytokines. How immune ...

journal_title：Clinical and experimental immunology

authors： Brown M,O'Reilly S

更新日期：2019-03-01 00:00:00

abstract：:Multiple halothane exposures in rabbits generate modified liver proteins or antigens that appear to incorporate the metabolic intermediate of halothane, trifluoroacetyl halide (TFA), as identified by specific anti-TFA antibody. These halothane-induced antigens are most prevalent throughout the second to fourth days fo...

journal_title：Clinical and experimental immunology

authors： Roth TP,Hubbard AK,Gandolfi AJ,Brown BR

更新日期：1988-05-01 00:00:00

abstract：:Autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 Caribbean patients with Schistosoma mansoni infection and 50 control subjects. Autoantibodies were detected by indirect immunofluorescence on HEp-2 cells pretreated with colchicine. The incidence of anti-vimentin antib...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Kataaha PK,Holborow EJ

更新日期：1989-08-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes fr...

journal_title：Clinical and experimental immunology

authors： Zwilling BS,Darrow R,Mcpeek M,Laufman H,Pearl D

更新日期：1990-12-01 00:00:00

abstract：:People receiving therapy with either 8-methoxypsoralen plus long wavelength ultraviolet radiation (PUVA) or medium wavelength ultraviolet radiation (UVB) have been studied to see whether their unresponsiveness to the contact sensitizer dinitrochlorobenzene (DNCB) is a form of immunological tolerance. It was confirmed ...

journal_title：Clinical and experimental immunology

authors： Friedmann PS,White SI,Parker S,Moss C,Matthews JN

更新日期：1989-04-01 00:00:00

abstract：:In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of te...

journal_title：Clinical and experimental immunology

authors： Demmert M,Faust K,Bohlmann MK,Tröger B,Göpel W,Herting E,Härtel C

更新日期：2012-02-01 00:00:00

abstract：:The interaction of cationic proteins with IgG, IgA and IgM were investigated by solid phase radioimmunoassay. All these immunoglobulins showed avid binding, IgM giving the strongest reaction, followed by IgA and then IgG. Fc fragments of IgG gave binding, but F(ab')2 fragments from the three main Ig classes did not, s...

journal_title：Clinical and experimental immunology

authors： Pambakian S,Poston RN

更新日期：1987-05-01 00:00:00

abstract：:Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therap...

journal_title：Clinical and experimental immunology

authors： Ivancic R,Iqbal H,deSilva B,Pan Q,Matrka L

更新日期：2020-02-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response, probably to a range of initiating causes. Chronic infection with Chlamydia pneumoniae (C.pn) has been suggested as one cause, but the nature of the association is controversial, in large part due to lack of an identified mechanism to link infection with the atherosclerotic ...

journal_title：Clinical and experimental immunology

authors： Clancy R,Ren Z,Pang G,Fletcher P,D'Este C

更新日期：2006-11-01 00:00:00

abstract：:Mutations in the signal transducer and activator of transcription 3 (STAT3) were reported to cause hyperimmunoglobulin E syndrome (HIES). The present study investigates T helper type 17 (Th17) responses triggered by the relevant stimuli Staphylococcus aureus and Candidia albicans in five 'classical' HIES patients, and...

journal_title：Clinical and experimental immunology

authors： van de Veerdonk FL,Marijnissen RJ,Joosten LA,Kullberg BJ,Drenth JP,Netea MG,van der Meer JW

更新日期：2010-01-01 00:00:00

abstract：:Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

journal_title：Clinical and experimental immunology

authors： Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

更新日期：1995-08-01 00:00:00

abstract：:The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play an important pathogenic role in murine arthritis. To clarify their pathophysiological roles in patients with rheumatoid arthritis (RA), we examined their expression and localization in peripheral blood mononuclear cells (PBMC). TNFAIP9 and ...

journal_title：Clinical and experimental immunology

authors： Takai C,Matsumoto I,Inoue A,Umeda N,Tanaka Y,Kurashima Y,Wada Y,Narita I,Sumida T

更新日期：2015-06-01 00:00:00

abstract：:In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

journal_title：Clinical and experimental immunology

authors： Nanra SK,Boettcher B

更新日期：1980-07-01 00:00:00

abstract：:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervou...

journal_title：Clinical and experimental immunology

authors： Samah B,Porcheray F,Gras G

更新日期：2008-03-01 00:00:00

abstract：:Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients wi...

journal_title：Clinical and experimental immunology

authors： Iwatani Y,Amino N,Kabutomori O,Mori H,Tamaki H,Motoi S,Izumiguchi Y,Miyai K

更新日期：1984-01-01 00:00:00

abstract：:In the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic...

journal_title：Clinical and experimental immunology

authors： Eckhardt J,Döbbeler M,König C,Kuczera K,Kuhnt C,Ostalecki C,Zinser E,Mak TW,Steinkasserer A,Lechmann M

更新日期：2015-07-01 00:00:00