In vitro and in vivo antifungal activities of BMY-28864, a water-soluble pradimicin derivative.

abstract：:The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Idelevich EA,Kriegeskorte A,Schleimer N,Peters G,von Eiff C,Becker K

更新日期：2018-03-27 00:00:00

abstract：:2'-Deoxy-2'-fluorocytidine (FdC) is a potent inhibitor of the hepatitis C virus RNA replicon in culture, and FdC-5'-triphosphate is an effective inhibitor of the NS5B polymerase. Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demons...

journal_title：Antimicrobial agents and chemotherapy

authors： Stuyver LJ,McBrayer TR,Whitaker T,Tharnish PM,Ramesh M,Lostia S,Cartee L,Shi J,Hobbs A,Schinazi RF,Watanabe KA,Otto MJ

更新日期：2004-02-01 00:00:00

abstract：:Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing Alcaligenes faecalis isolates associated with a small outb...

journal_title：Antimicrobial agents and chemotherapy

authors： Al Laham N,Chavda KD,Cienfuegos-Gallet AV,Kreiswirth BN,Chen L

更新日期：2017-10-24 00:00:00

abstract：:As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomolar concentrations of itraconazole. Fifty percent inhibition of ergoste...

journal_title：Antimicrobial agents and chemotherapy

authors： Vanden Bossche H,Marichal P,Le Jeune L,Coene MC,Gorrens J,Cools W

更新日期：1993-10-01 00:00:00

abstract：:The NS3/4A protease from hepatitis C virus (HCV) plays a key role in viral replication. We report a system for monitoring the activity of this enzyme in single living mammalian cells. We constructed a fluorescence resonance energy transfer (FRET) probe that consists of an enhanced cyan fluorescent protein-citrine fusi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabariegos R,Picazo F,Domingo B,Franco S,Martinez MA,Llopis J

更新日期：2009-02-01 00:00:00

abstract：:The in vitro activity of tosufloxacin (A-61827; T-3262) against 15 clinical isolates of Chlamydia trachomatis and 31 recent clinical isolates of Neisseria gonorrhoeae, including 15 spectinomycin-resistant N. gonorrhoeae and 16 penicillinase-producing N. gonorrhoeae, was determined. Tosufloxacin was compared with doxyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Segreti J,Hirsch DJ,Harris AA,Kapell KS,Orbach H,Kessler HA

更新日期：1990-06-01 00:00:00

abstract：:A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with M(r)s of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kar AK,Ghosh AS,Chauhan K,Ahamed J,Basu J,Chakrabarti P,Kundu M

更新日期：1997-10-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:Candida albicans readily forms biofilms on the surface on indwelling medical devices, and these biofilms serve as a source of local and systemic infections. It is estimated that 27% of nosocomial C. albicans bloodstream infections are polymicrobial, with Staphylococcus aureus as the third most common organism isolated...

journal_title：Antimicrobial agents and chemotherapy

authors： Harriott MM,Noverr MC

更新日期：2009-09-01 00:00:00

abstract：:Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive care units (ICUs) in central Greece, compared critically ill, mechanically ventilated patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsolaki V,Mantzarlis K,Mpakalis A,Malli E,Tsimpoukas F,Tsirogianni A,Papagiannitsis C,Zygoulis P,Papadonta ME,Petinaki E,Makris D,Zakynthinos E

更新日期：2020-02-21 00:00:00

abstract：:The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss WJ,Pulse ME,Nguyen P,Peterson K,Silva J,Simecka JW,Valtierra D,Sabet M,Griffith DC

更新日期：2017-12-21 00:00:00

abstract：:Various steroids were tested for their effects upon gonococcal O2 consumption and glucose catabolism. The ability to inhibit gonococcal O2 uptake appeared to be related to the molecular configuration of the steroid. The presence of lipophilic groups enhanced inhibition, whereas the addition of hydrophilic groups marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Lysko PG,Morse SA

更新日期：1980-08-01 00:00:00

abstract：:The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of < or = 200 cells per mm3 in order to define a dosing regimen for the treatment of Pneumocystis carinii pneumonia. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon R,Pozniak AL,Watt HM,Rolan P,Posner J

更新日期：1996-03-01 00:00:00

abstract：:The dose dependence of mezlocillin pharmacokinetics was examined in relation to renal function after intravenous doses of 1 and 5 g in 16 subjects with various degrees of renal impairment. Dose and time-average model-independent physiological parameters were calculated from plasma concentration and urinary excretion d...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangione A,Boudinot FD,Schultz RM,Jusko WJ

更新日期：1982-03-01 00:00:00

abstract：:The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. The pharmacokinetic behavior of trimetrexate administered either by intravenous bolus or orally was studied...

journal_title：Antimicrobial agents and chemotherapy

authors： Rogers P,Allegra CJ,Murphy RF,Drake JC,Masur H,Poplack DG,Chabner BA,Parrillo JE,Lane HC,Balis FM

更新日期：1988-03-01 00:00:00

abstract：:Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Ressler R,Wilkins J

更新日期：1974-11-01 00:00:00

abstract：:We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantón E,Pemán J,Valentín A,Espinel-Ingroff A,Gobernado M

更新日期：2009-07-01 00:00:00

abstract：:We have surveyed the susceptibility of 1,575 clinical isolates of the Bacteroides fragilis group of organisms to cefoxitin and eight other antimicrobial agents. Eleven isolates, 0.7% of the total, were highly cefoxitin resistant and had minimum inhibitory concentrations of greater than or equal to 64 micrograms/ml. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuchural GJ Jr,Tally FP,Jacobus NV,Marsh PK,Mayhew JW

更新日期：1983-12-01 00:00:00

abstract：:The objectives of this study were to (i) construct a population pharmacokinetic (PK) model able to describe vancomycin (VAN) concentrations in serum in pediatric patients, (ii) determine VAN PK parameters in this population, and (iii) validate the predictive ability of this model in a naive pediatric population. Data ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamarre P,Lebel D,Ducharme MP

更新日期：2000-02-01 00:00:00

abstract：:Primary amoebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri The amoeba migrates along the olfactory nerve to the brain, resulting in seizures, coma, and, eventually, death. Previous research has shown that Naegleria gruberi, a close relative of N. fowleri, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarink MJ,Tielens AGM,Verbon A,Sutak R,van Hellemond JJ

更新日期：2020-07-22 00:00:00

abstract：:Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH2) for its union to the mitochondrial bc1 complex, preventing the ubiquinone-8,9 (UQ) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused on UQ biosynthesis in Plasmodium falciparum and adopted proof-of-c...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdaguer IB,Crispim M,Zafra CA,Sussmann RAC,Buriticá NL,Melo HR,Azevedo MF,Almeida FG,Kimura EA,Katzin AM

更新日期：2021-01-25 00:00:00

abstract：:The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatel...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhou Z,Griffing SM,de Oliveira AM,McCollum AM,Quezada WM,Arrospide N,Escalante AA,Udhayakumar V

更新日期：2008-02-01 00:00:00

abstract：:Initial studies indicate that rifampin may be useful for the treatment of Staphylococcus aureus infections. Because bacterial resistance to rifampin may develop rapidly, its widespread use could result in the emergence of a resistant flora. This study evaluates the effectiveness of rifampin in reducing the nasal carri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sande MA,Mandell GL

更新日期：1975-03-01 00:00:00

abstract：:A double-site enzyme-linked lactate dehydrogenase enzyme immunodetection assay was tested against field isolates of Plasmodium falciparum for assessing in vitro drug susceptibilities to a wide range of antimalarial drugs. Its sensitivity allowed the use of parasite densities as low as 200 parasites/microl of blood. Be...

journal_title：Antimicrobial agents and chemotherapy

authors： Brockman A,Singlam S,Phiaphun L,Looareesuwan S,White NJ,Nosten F

更新日期：2004-04-01 00:00:00

abstract：:The penetration of ciprofloxacin into heart tissue (valve and myocardium), mediastinal fat, and sternal bone marrow was the object of a prospective nonrandomized study involving 36 patients undergoing mitral and/or aortic valve replacement. Patients were divided into two groups of 18. Group 1 patients were administere...

journal_title：Antimicrobial agents and chemotherapy

authors： Mertes PM,Voiriot P,Dopff C,Scholl H,Clavey M,Villemot JP,Canton P,Dureux JB

更新日期：1990-03-01 00:00:00

abstract：:Fifty strains of Mycoplasma pneumoniae in L cells were tested for susceptibility to macrolide antibiotics. Rokitamycin, a new macrolide antibiotic, was most active against these organisms, with an MIC for 90% of strains of 0.007 microgram/ml. The MICs of erythromycin, josamycin, and kitasamycin for 90% of strains were...

journal_title：Antimicrobial agents and chemotherapy

authors： Misu T,Arai S,Furukawa M,Yamamoto Y,Miyazaki T

更新日期：1987-11-01 00:00:00

abstract：:Pseudomonas aeruginosa pneumonia remains a difficult therapeutic problem. Optimal doses and modes of administration of single agents often do not result in acceptable outcomes. Further, emergence of resistance occurs frequently in this setting with single-agent chemotherapy. The purpose of these experiments was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Liu W,Fikes S,Brown D,Drusano GL

更新日期：2013-06-01 00:00:00

abstract：:Enterovirus 71 is one of the most important pathogens in the family of Picornaviridae that can cause severe complications in the postpoliovirus era, such as encephalitis, pulmonary edema, and even death. Pyridyl imidazolidinone is a novel class of potent and selective human enterovirus 71 inhibitor. Pyridyl imidazolid...

journal_title：Antimicrobial agents and chemotherapy

authors： Shih SR,Tsai MC,Tseng SN,Won KF,Shia KS,Li WT,Chern JH,Chen GW,Lee CC,Lee YC,Peng KC,Chao YS

更新日期：2004-09-01 00:00:00

abstract：:Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or in combination with gentamicin. The in vitro tests consisted of determinations of minimal inhibitory concentrations (MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Brook I,Coolbaugh JC,Walker RI,Weiss E

更新日期：1984-01-01 00:00:00

abstract：:beta-Lactamase was purified from a strain of Legionella gormanii. The molecular weight of the purified enzyme was 25,000, and its isoelectric point was 10.5. The enzyme hydrolyzed oxyiminocephalosporins, cephamycins, penicillins, and imipenem. The enzyme activity was inhibited by EDTA, Hg2+, and Cu2+, but not by clavu...

journal_title：Antimicrobial agents and chemotherapy

authors： Fujii T,Sato K,Miyata K,Inoue M,Mitsuhashi S

更新日期：1986-05-01 00:00:00