Abstract:
:In this George Simon Lecture, I have tried to present a simplistic yet philosophical approach to the physiological processes of adaptation of circulatory and respiratory function in response to pathophysiological challenge. The objective of the body is to achieve a normal ventilation-perfusion ratio of 1 in order to optimise blood-gas exchange in a wide variety of pathological conditions. It is all a question of the right ingredients (oxygen in atmospheric air and reduced haemoglobin in desaturated blood), in the right copious amounts (100 ml/s), in the right proportion (1:1) and in the right place (alveolar capillary membrane). In order to demonstrate the above concepts, a variety of well known conditions, congenital and acquired, have been discussed in the developing infant lung and the adult mature lung; some primarily cardiovascular, others primarily respiratory; some conditions resulting in permanent and others resulting in temporary and reversible major readjustments of the blood supply to the lung. The emphasis has been to illustrate that simple, unsophisticated radiological techniques may provide a substantial amount of valuable information concerning the remarkable capacity of the pulmonary circulation to adapt to varying physiological or pathological demands in order to conserve our precious respiratory resources. George Simon, like all good doctors, had a tremendous respect for the ability of the body to respond to these challenges. He always emphasised the important basic principles rather than fine minutiae. It is hoped that this lecture in his honour follows these principles which he preached so well.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Grainger RGdoi
10.1016/s0009-9260(85)80092-1subject
Has Abstractpub_date
1985-03-01 00:00:00pages
103-16issue
2eissn
0009-9260issn
1365-229Xpii
S0009-9260(85)80092-1journal_volume
36pub_type
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journal_title:Clinical radiology
pub_type: 杂志文章,多中心研究
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doi:10.1016/j.crad.2020.09.025
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2003.08.005
更新日期:2004-02-01 00:00:00
abstract::Castleman disease is a rare, benign disorder characterized by proliferation of lymphoid tissue most commonly presenting as a solitary mediastinal mass. We discuss the radiological findings in a 10-year-old female child with a mesenteric Castleman tumour presenting with intermittent abdominal pain and a persistently el...
journal_title:Clinical radiology
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doi:10.1016/s0009-9260(05)80578-1
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journal_title:Clinical radiology
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doi:10.1016/j.crad.2008.01.008
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2012.08.002
更新日期:2012-12-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(81)80288-7
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journal_title:Clinical radiology
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doi:10.1016/j.crad.2018.01.016
更新日期:2018-06-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2015.01.003
更新日期:2015-05-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(88)80279-4
更新日期:1988-07-01 00:00:00
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journal_title:Clinical radiology
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doi:10.1016/j.crad.2018.01.003
更新日期:2018-04-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81665-4
更新日期:1990-04-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80198-7
更新日期:1985-09-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2019.10.001
更新日期:2020-02-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2007.07.023
更新日期:2008-02-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(83)80432-2
更新日期:1983-11-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2013.07.014
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80087-x
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pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80967-5
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doi:10.1016/j.crad.2006.06.011
更新日期:2006-11-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(99)91071-1
更新日期:1999-02-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2017.12.003
更新日期:2019-01-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/s0009-9260(05)83220-9
更新日期:1995-11-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81237-1
更新日期:1993-11-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2019.02.010
更新日期:2019-06-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2007.09.004
更新日期:2008-08-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80083-0
更新日期:1985-05-01 00:00:00
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journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(81)80338-8
更新日期:1981-11-01 00:00:00