Presynaptic transmitter release is specified by postsynaptic neurons of Aplysia buccal ganglia.

Abstract:

:1. In Aplysia buccal ganglia, in which dual presynaptic neurons innervate multiple postsynaptic cells, strengths of the same identified synapses differ from animal to animal, consistent with developmental or plastic modulation. Synaptic strengths are specified by the postsynaptic neuron, so that synaptic current amplitudes are similar for inputs from different presynaptic cells converging on a postsynaptic cell but different for branches of the same neuron diverging onto different targets. 2. The coefficient of variation method of quantal analysis reveals that differences in synaptic strength, although specified postsynaptically, result partially from differences in the number of quanta released by presynaptic terminals. 3. This quantization is consistent with classical presynaptic models and suggests retrograde modulation of quantal release as postulated for hippocampal long-term potentiation.

journal_name

J Neurophysiol

authors

Gardner D

doi

10.1152/jn.1991.66.6.2150

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

2150-4

issue

6

eissn

0022-3077

issn

1522-1598

journal_volume

66

pub_type

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