Abstract:
:Forty-three patients with evaluable metastatic breast cancer refractory to hormonal agents and extensive combination chemotherapy including doxorubicin were treated with mitomycin, 20 mg/m2 intravenously every 6 weeks. There were five partial responses (12%) and three minor responses (7%), with a mean time to progression of 5 months and 3.5 months, respectively. Thrombocytopenia was the major dose-limiting toxicity, and myelosuppression was cumulative. Cardiac dysfunction was observed in 12% of patients. Mitomycin had some antitumor activity in this group of metastatic breast cancer patients refractory to extensive combination chemotherapy including doxorubicin.
journal_name
Cancerjournal_title
Cancerauthors
Pasterz RB,Buzdar AU,Hortobagyi GN,Blumenschein GRdoi
10.1002/1097-0142(19851115)56:10<2381::aid-cncr282subject
Has Abstractpub_date
1985-11-15 00:00:00pages
2381-4issue
10eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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