Abstract:
:To evaluate the effect of Bicitra (Willen Drug Company, Baltimore, Maryland), a commercial preparation of sodium citrate and metoclopramide, on gastric contents 150 elective outpatients allocated into six groups with 25 patients in each group were studied. Patients in Group 1 served as controls. Patients in Groups 2, 3, 5, and 6 received Bicitra, po, either 15 ml (Groups 2 and 5) or 30 ml (Groups 3 and 6). In addition, patients in Groups 5 and 6 also received metoclopramide 10 mg, iv; Group 4 patients received metoclopramide 10 mg, iv. Eighty-eight per cent of patients in the control group had a gastric pH less than or equal to 2.5, while 36% had a gastric content volume greater than or equal to 25 ml with pH less than or equal to 2.5. Bicitra, 15 ml and 30 ml, po, increased mean gastric pH and decreased the proportion of patients with a gastric pH less than or equal to 2.5 to 32 and 16%, respectively, in Groups 2 and 3. However, Bicitra 15 ml and 30 ml, increased the mean gastric volume in Group 3 and also increased the proportion of patients with a gastric volume greater than or equal to 25 ml to 56% in Group 2 and 84% in Group 3. The addition of metoclopramide 10 mg, iv, to Bicitra reduced the proportion of patients with a gastric volume greater than or equal to 25 ml in Groups 5 and 6 to 28 and 36%, respectively. Metoclopramide (Group 6) independently reduced mean gastric volume (15.6 ml vs. 32.7 ml) and the proportion of patients with a gastric volume greater than or equal to 25 ml (20% vs. 36%). Bicitra and metoclopramide combination significantly reduced the proportion of patients with gastric contents greater than or equal to 25 ml with pH less than or equal to 2.5.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Manchikanti L,Grow JB,Colliver JA,Hadley CH,Hohlbein LJdoi
10.1097/00000542-198510000-00006subject
Has Abstractpub_date
1985-10-01 00:00:00pages
378-84issue
4eissn
0003-3022issn
1528-1175journal_volume
63pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:Exposure of rhesus macaque fetuses for 24 h or neonates for 9 h to ketamine anesthesia causes neuroapoptosis in the developing brain. The current study clarifies the minimum exposure required for and the extent and spatial distribution of ketamine-induced neuroapoptosis in rhesus fetuses and neonates. METHO...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318242b2cd
更新日期:2012-02-01 00:00:00
abstract::The effects on fertility and reproductive wastage of 110 female Swiss/Webster mice and postnatal survival of their offspring were examined after exposure to either air, 0.4% isoflurane, or 0.1% isoflurane. Treatments were for 4 h daily for 2 weeks before and during pregnancy. In a second experiment, the effects on fer...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198512000-00017
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Chronic pain models are commonly defined as either nerve-injury or inflammation models, but recent work suggests inflammatory processes are important in nerve injury-induced pain. METHODS:In the rat spinal nerve ligation model, the authors examined effects of systemic corticosteroid triamcinolone acetonide ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/01.anes.0000278907.37774.8d
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Ventilator-associated pneumonia (VAP) requires early diagnosis and adequate antibiotic therapy. The aim of this prospective postmortem study was to assess the accuracy of direct examination and quantification of intracellular organisms (ICO) for the diagnosis of VAP. METHODS:Total and differential cell coun...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199708000-00013
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3182834d77
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Forced-air warming is sometimes unable to maintain perioperative normothermia. Therefore, the authors compared heat transfer, regional heat distribution, and core rewarming of forced-air warming with a novel circulating-water garment. METHODS:Nine volunteers were each evaluated on two randomly ordered study...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200405000-00005
更新日期:2004-05-01 00:00:00
abstract::Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal flux transducers. Oxygen consumption was measured and converted...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199104000-00011
更新日期:1991-04-01 00:00:00
abstract::To determine whether neuronal firing is affected by anesthetics, the behavior of neurons in the mesencephalic reticular formation in response to repetitive somatosensory stimulation at 2/sec was studied during wakefulness and during nitrous oxide, halothane, and thiopental anesthesia in the cat. With clinical doses of...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197710000-00005
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:The authors sought to understand neural correlates of anesthetic-induced unconsciousness. Cortical gamma oscillations have been associated with neural processes supporting conscious perception, but the effect of general anesthesia on these oscillations is controversial. In this study, the authors examined th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200505000-00012
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Massive release of central excitatory neurotransmitters is an important initial step in ischemic neuronal injury, and modification of this process may provide neuroprotection. We studied the protective effects of the voltage-dependent sodium channel antagonist riluzole and the N-methyl-d-aspartate receptor a...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200011000-00025
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Although one-lung ventilation (OLV) has become an established procedure during thoracic surgery, sparse data exist about inflammatory alterations in the deflated, reventilated lung. The aim of this study was to prospectively investigate the effect of OLV on the pulmonary inflammatory response and to assess p...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e3181a10731
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Basal cytotoxic activity of NK cells, a subtype of lymphocytes involved in the nonspecific immune response to viruses, tumors, and some bacteria, is altered in the postoperative period. The current study examines the effects of halothane and isoflurane on interferon-induced stimulation of NK cell cytotoxicit...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199304000-00013
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that anesthetic action within the spinal cord is important in suppressing somatic responses to painful stimuli. Whether the brain influences this response is not clear. This study was designed to test the hypothesis that the brain affects anesthetic requirements. METHODS:Six goats w...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199412000-00027
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:This study compared two insertion techniques of ProSeal laryngeal mask airway. METHODS:A total of 160 female patients (American Society of Anesthesiologists physical status I or II; age 18-80 yrs) undergoing gynecologic surgery were randomly allocated to the standard or rotational technique groups. In the s...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/ALN.0b013e31819b5d40
更新日期:2009-04-01 00:00:00
abstract::To evaluate the effect of aging on the distribution, metabolism, and neuromuscular junction sensitivity to pancuronium and vecuronium, the authors determined the pharmacokinetics and pharmacodynamics of these drugs in 12 healthy elderly subjects (70-84 yr) and 12 young adults (30-57 yr) during halothane-nitrous oxide ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198707000-00008
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Anesthesia during the synaptogenic period induces dendritic spine formation, which may affect neurodevelopment. The authors, therefore, evaluated whether changes in synaptic transmission after dendritic spine formation induced by sevoflurane were associated with long-term behavioral changes. The effects of s...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000001470
更新日期:2017-02-01 00:00:00
abstract::The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of gen...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198101000-00010
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:In pediatric patients, the Bispectral Index (BIS), derived from the electroencephalogram, and the composite A-Line autoregressive index (cAAI), derived from auditory evoked potentials and the electroencephalogram, have been used as measurements of depth of hypnosis during anesthesia. The performance and reli...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31816bbd6e
更新日期:2008-05-01 00:00:00
abstract::EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197704000-00005
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Long-term neuroprotection by isoflurane has been questioned. The authors examined factors in experimental models potentially critical to definition of enduring isoflurane neuroprotection. METHODS:Rats were prepared for temporary middle cerebral artery occlusion (MCAO). Pericranial normothermia was maintaine...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200701000-00017
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Sepsis and septic shock are severe inflammatory conditions related to high morbidity and mortality. We performed a systematic review with meta-analysis of randomized trials to assess whether extracorporeal blood purification reduces mortality in this setting. METHODS:Electronic databases were searched for p...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析
doi:10.1097/ALN.0000000000002820
更新日期:2019-09-01 00:00:00
abstract::The dose-response and plasma concentration-response relationships for pancuronium in man were studied during its intravenous administration to eight patients at a rate of 1.62 microgram/kg/min. The (log) dose-response relationships resulted in a sigmoid curve that was linear in its central range. At 20, 50 and 80 per ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197908000-00004
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Procedure times are important variables that often are included in studies of quality and efficiency. However, due to the need for costly chart review, most studies are limited to single-institution analyses. In this article, the authors describe how well the anesthesia claim from Medicare can estimate chart...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200702000-00024
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Awareness during anesthesia is foremost assessed with postoperative interviews, which may underestimate its incidence. On-line monitors such as the Bispectral Index and patient response to verbal command are not necessarily commonly used. This study investigated response to command during deep sedation (Bisp...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-200309000-00011
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are twofold less sensitive to hypnotic actions of ketamine...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e318287b7c8
更新日期:2013-04-01 00:00:00
abstract::Pain perception to minor physical stimuli has been hypothesized to be related to subsequent pain ratings after surgery. The objective of this systematic review was to evaluate the correlation between preoperative pain sensitivity and postoperative pain intensity. After a literature search of MEDLINE, EMBASE, and meeti...
journal_title:Anesthesiology
pub_type: 杂志文章,评审
doi:10.1097/ALN.0b013e3181f85ed2
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Propofol is an alternative to thiopental as an intravenous induction agent for cesarean section. Because it has relaxant effects on vascular and other smooth muscles, the authors set out to determine whether propofol has any effect on pregnant human uterine smooth muscle in an isolated preparation. METHODS:...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199807000-00017
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Glutamate has been implicated in the pathophysiology of neuronal injury associated with cerebral hypoxia-ischemia. A model using chronic in utero microdialysis was developed to sample the extracellular space of the fetal brain. Using this model, we tested the hypothesis that glutamate efflux from the parasag...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199502000-00022
更新日期:1995-02-01 00:00:00
abstract::The authors have previously attributed the mechanism for the 50-67% decrease in the required dose of thiopental for induction of anesthesia in aged human patients to a decrease in the initial distribution volume for thiopental. Using a larger group of patients and volunteers studied in the laboratory, the authors have...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199003000-00003
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Methylprednisolone, dexamethasone, and other glucocorticoids have been found effective against nausea and vomiting induced by chemotherapy and surgery. Although the specific 5-hydroxytriptamine3 (5-HT3) receptor antagonists such as ondansetron and ramosetron are used as antiemetics, reports show that the use...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200409000-00014
更新日期:2004-09-01 00:00:00