Unsteady gaze fixation enhances the severity of MS intention tremor.


BACKGROUND:Patients with arm intention tremor due to multiple sclerosis (MS) often manifest eye movement deficits, illustrating the role of infratentorial brain in both ocular and manual movement control. Our previous study showed that both the amplitude of intention tremor and eye fixational movements were greatly enhanced after coordinated eye-hand action toward stationary targets vs during hand movements with continuous target fixation. OBJECTIVE:The present study tested, during coordinated step-tracking movements, the hypothesis that the amplitude of hand intention tremor was influenced by (unsteady) gaze fixation onto the target. METHODS:Simultaneously recorded eye and hand tracking movements were compared between 13 MS patients with intention tremor and 14 healthy controls over conditions in which the magnitude of the primary eye and hand tracking movements, as well as their ratio, were altered. RESULTS:Patients always made larger fixational eye movements around the visual targets than the controls. In the patient group, the size of fixational eye movements decreased following a reduction in the magnitude of the preceding saccadic movement, and most interestingly, was accompanied with a decrease in tremor amplitude. An alteration in the magnitude of the primary hand movement did not affect the tremor severity. CONCLUSIONS:In patients with multiple sclerosis with intention tremor, the unsteady gaze fixation on the visual targets is proportional to the magnitude of the preceding saccades, and influences the severity of intention tremor during eye-hand coordinated visuomotor tasks.






Feys P,Helsen W,Nuttin B,Lavrysen A,Ketelaer P,Swinnen S,Liu X




Has Abstract


2008-01-08 00:00:00














  • Is late-onset multiple sclerosis associated with a worse outcome?

    abstract:OBJECTIVE:To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors. METHODS:Patients with definite MS, onset prior to July 1988, registered with a BCMS clinic before July 1998, with at least one E...


    pub_type: 杂志文章


    authors: Tremlett H,Devonshire V

    更新日期:2006-09-26 00:00:00

  • Brain white matter volume abnormalities in Lesch-Nyhan disease and its variants.

    abstract:OBJECTIVE:We sought to examine brain white matter abnormalities based on MRI in adults with Lesch-Nyhan disease (LND) or an attenuated variant (LNV) of this rare, X-linked neurodevelopmental disorder of purine metabolism. METHODS:In this observational study, we compared 21 adults with LND, 17 with LNV, and 33 age-, se...


    pub_type: 杂志文章


    authors: Schretlen DJ,Varvaris M,Vannorsdall TD,Gordon B,Harris JC,Jinnah HA

    更新日期:2015-01-13 00:00:00

  • Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke.

    abstract:OBJECTIVE:To analyze the effect of age-related DNA methylation changes in multiple cytosine-phosphate-guanine (CpG) sites (biological age [b-age]) on patient outcomes at 3 months after an ischemic stroke. METHODS:We included 511 patients with first-ever acute ischemic stroke assessed at Hospital del Mar (Barcelona, Sp...


    pub_type: 杂志文章


    authors: Soriano-Tárraga C,Mola-Caminal M,Giralt-Steinhauer E,Ois A,Rodríguez-Campello A,Cuadrado-Godia E,Gómez-González A,Vivanco-Hidalgo RM,Fernández-Cadenas I,Cullell N,Roquer J,Jiménez-Conde J

    更新日期:2017-08-22 00:00:00

  • Type 3 (adult) GM1 gangliosidosis: case report.

    abstract::GM1 gangliosidosis is usually a pediatric disease caused by hereditary acid beta-galactosidase deficiency. There have been a few cases in adults. We saw a 51-year-old Japanese man with type 3 GM1 gangliosidosis who was manifesting dementia, dysarthria, gait disturbance, and limb rigidity. Radiologic studies showed pla...


    pub_type: 杂志文章


    authors: Ohta K,Tsuji S,Mizuno Y,Atsumi T,Yahagi T,Miyatake T

    更新日期:1985-10-01 00:00:00

  • Prognosis of photoparoxysmal response in nonepileptic patients.

    abstract::Photoparoxysmal response (PPR) is sometimes incidentally encountered in EEGs performed for evaluation of nonepileptic symptoms. We conducted the first long-term study of a cohort of nonepileptic patients to determine their risk of having seizures subsequent to incidental recording of PPR. After 6 to 12 years (mean, 9 ...


    pub_type: 杂志文章


    authors: So EL,Ruggles KH,Ahmann PA,Olson KA

    更新日期:1993-09-01 00:00:00

  • Peripheral neuropathy in classic Niemann-Pick disease: ultrastructure of nerves and skeletal muscles.

    abstract::A patient with classic (type A) Niemann-Pick disease had the usual clinical signs of failure to thrive, hepatosplenomegaly, and intellectual deterioration in the first year of life. In addition, there was striking hypotonia, areflexia, and abnormal nerve conduction velocities. Pathologically, the Schwann cells were fi...


    pub_type: 杂志文章


    authors: Gumbinas M,Larsen M,Mei Liu H

    更新日期:1975-02-01 00:00:00

  • Firing rates of human motor units in partially denervated muscle.

    abstract::Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...


    pub_type: 杂志文章


    authors: Miller RG,Sherratt M

    更新日期:1978-12-01 00:00:00

  • Motor perseverative behavior on a line cancellation task.

    abstract:OBJECTIVES:To study the behavioral and neuroanatomic characteristics of perseverative behavior encountered on a target cancellation task in patients with neglect. METHODS:Motor perseverative behavior during line cancellation task was evaluated retrospectively in 60 patients with left hemispatial neglect from right hem...


    pub_type: 杂志文章


    authors: Na DL,Adair JC,Kang Y,Chung CS,Lee KH,Heilman KM

    更新日期:1999-05-12 00:00:00

  • Response of cluster headache to psilocybin and LSD.

    abstract::The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin ...


    pub_type: 杂志文章


    authors: Sewell RA,Halpern JH,Pope HG Jr

    更新日期:2006-06-27 00:00:00

  • Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline.

    abstract:OBJECTIVE:To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up. METHODS:We analyzed data from 11,709 participants without a history of coronary heart diseas...


    pub_type: 杂志文章


    authors: Rawlings AM,Juraschek SP,Heiss G,Hughes T,Meyer ML,Selvin E,Sharrett AR,Windham BG,Gottesman RF

    更新日期:2018-08-21 00:00:00

  • Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation.

    abstract:OBJECTIVE:To perform a systematic review and meta-analysis of studies reporting recurrent intracranial hemorrhage (ICH) and ischemic stroke (IS) in ICH survivors with atrial fibrillation (AF) during long-term follow-up. METHODS:A comprehensive literature search including MEDLINE, EMBASE, Cochrane library, clinical tri...


    pub_type: 杂志文章,meta分析,评审


    authors: Korompoki E,Filippidis FT,Nielsen PB,Del Giudice A,Lip GYH,Kuramatsu JB,Huttner HB,Fang J,Schulman S,Martí-Fàbregas J,Gathier CS,Viswanathan A,Biffi A,Poli D,Weimar C,Malzahn U,Heuschmann P,Veltkamp R

    更新日期:2017-08-15 00:00:00

  • Silent MRI infarcts and the risk of future stroke: the cardiovascular health study.

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    pub_type: 杂志文章


    authors: Bernick C,Kuller L,Dulberg C,Longstreth WT Jr,Manolio T,Beauchamp N,Price T,Cardiovascular Health Study Collaborative Reseach Group.

    更新日期:2001-10-09 00:00:00

  • Limb-kinetic apraxia in Parkinson disease.

    abstract::To learn if limb-kinetic apraxia (LKA) is associated with Parkinson disease (PD), participants with PD (on medications) and control subjects performed finger tapping (FT), measuring movement speed, and performed coin rotation (CR), measuring precise coordinated but independent finger movements and speed. There were no...


    pub_type: 杂志文章


    authors: Quencer K,Okun MS,Crucian G,Fernandez HH,Skidmore F,Heilman KM

    更新日期:2007-01-09 00:00:00

  • Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.

    abstract:OBJECTIVE:To assess the genetic contribution of TBK1, a gene implicated in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and ALS patient cohorts containing a significant part of genetically unresolved patients. METHODS:We sequenced TBK1 in a hospital-based cohort of 48...


    pub_type: 杂志文章


    authors: Gijselinck I,Van Mossevelde S,van der Zee J,Sieben A,Philtjens S,Heeman B,Engelborghs S,Vandenbulcke M,De Baets G,Bäumer V,Cuijt I,Van den Broeck M,Peeters K,Mattheijssens M,Rousseau F,Vandenberghe R,De Jonghe P,Cras P

    更新日期:2015-12-15 00:00:00

  • Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension.

    abstract:BACKGROUND:Elevated serum retinol, CSF retinol, and serum retinol binding protein (RBP) levels have been found in some patients with idiopathic intracranial hypertension (IIH), but serum and CSF retinol levels have not been studied in matched serum and CSF samples in patients with IIH. OBJECTIVE:To determine whether s...


    pub_type: 杂志文章


    authors: Tabassi A,Salmasi AH,Jalali M

    更新日期:2005-06-14 00:00:00

  • Patient-centered outcomes: translating clinical efficacy into benefits on health-related quality of life.

    abstract:BACKGROUND:Multiple sclerosis (MS) is a neurodegenerative disease associated with marked impairments in health-related quality of life (HRQoL). Although standard clinical end points such as the Expanded Disability Status Scale and annualized relapse rate remain useful in assessing MS activity and severity, these measur...


    pub_type: 杂志文章


    authors: Miller D,Rudick RA,Hutchinson M

    更新日期:2010-04-27 00:00:00

  • Retinal microvascular signs and risk of stroke and stroke mortality.

    abstract:OBJECTIVE:The purpose of this study was to assess the relation of retinal microvascular signs and incident stroke and stroke mortality in an older population. METHODS:The authors took retinal photographs on baseline participants (3,654 patients aged 49+ years) of the Blue Mountains Eye Study (1992 to 1994). They asses...


    pub_type: 杂志文章


    authors: Mitchell P,Wang JJ,Wong TY,Smith W,Klein R,Leeder SR

    更新日期:2005-10-11 00:00:00

  • Interrater reliability in the neuropathologic diagnosis of Alzheimer's disease.

    abstract::Three neuropathologists evaluated brain sections from 43 aged subjects for the presence of Alzheimer's disease. Moderate-to-substantial agreement was obtained. After discussion of disparate diagnoses, agreement was almost perfect for standardized and substantial for personal criteria. We conclude that reproducibility ...


    pub_type: 杂志文章


    authors: Paulus W,Bancher C,Jellinger K

    更新日期:1992-02-01 00:00:00

  • Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.

    abstract::With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications. In this article, four patient reports of a sp...


    pub_type: 杂志文章


    authors: Diamond S,Pepper BJ,Diamond ML,Freitag FG,Urban GJ,Erdemoglu AK

    更新日期:1998-07-01 00:00:00

  • Infarcts with a cardiac source of embolism in the NINCDS Stroke Data Bank: historical features.

    abstract::To gain insight into the historical features relevant to the diagnosis of cardiac embolic strokes, we studied the 1,290 patients with cerebral infarcts in the NINCDS Stroke Data Bank. Based solely on the presence of cardiac sources of embolism, we divided the patients into groups of high (n = 250), medium (n = 166), a...


    pub_type: 杂志文章


    authors: Kittner SJ,Sharkness CM,Price TR,Plotnick GD,Dambrosia JM,Wolf PA,Mohr JP,Hier DB,Kase CS,Tuhrim S

    更新日期:1990-02-01 00:00:00

  • Measurement of narcolepsy symptoms: The Narcolepsy Severity Scale.

    abstract:OBJECTIVE:To validate the Narcolepsy Severity Scale (NSS), a brief clinical instrument to evaluate the severity and consequences of symptoms in patients with narcolepsy type 1 (NT1). METHODS:A 15-item scale to assess the frequency and severity of excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, slee...


    pub_type: 杂志文章


    authors: Dauvilliers Y,Beziat S,Pesenti C,Lopez R,Barateau L,Carlander B,Luca G,Tafti M,Morin CM,Billiard M,Jaussent I

    更新日期:2017-04-04 00:00:00

  • Cerebral dysfunction after chronic hypoxia in children.

    abstract::Although the long-term effects of acute anoxia have been studied, the effects of chronic hypoxia on the developing human brain have received little attention. We studied children with a cyanotic congenital heart defect to assess the impact of chronic hypoxia by eight measures: neurologic examination, visual evoked res...


    pub_type: 杂志文章


    authors: O'Dougherty M,Wright FS,Loewenson RB,Torres F

    更新日期:1985-01-01 00:00:00

  • Cutaneous adverse events in multiple sclerosis patients treated with daclizumab.

    abstract:OBJECTIVE:To analyze the spectrum and mechanisms of cutaneous adverse events (AEs) in patients with multiple sclerosis treated with daclizumab high-yield process (DAC-HYP). METHODS:A total of 31 participants in an institutional review board-approved open-label phase I study of DAC-HYP (NCT01143441) were prospectively ...


    pub_type: 杂志文章


    authors: Cortese I,Ohayon J,Fenton K,Lee CC,Raffeld M,Cowen EW,DiGiovanna JJ,Bielekova B

    更新日期:2016-03-01 00:00:00

  • Late-onset depressive symptoms increase the risk of dementia in small vessel disease.

    abstract:OBJECTIVE:We prospectively investigated the role of depressive symptoms (DS) on all-cause dementia in a population with small vessel disease (SVD), considering onset age of DS and cognitive performance. METHODS:The RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort) is a prospect...


    pub_type: 杂志文章


    authors: van Uden IW,van der Holst HM,van Leijsen EM,Tuladhar AM,van Norden AG,de Laat KF,Claassen JA,van Dijk EJ,Kessels RP,Richard E,Tendolkar I,de Leeuw FE

    更新日期:2016-09-13 00:00:00

  • Evaluation of sleep and daytime somnolence in spinocerebellar ataxia type 6 (SCA6).

    abstract::To determine the frequency of subjective sleep problems in spinocerebellar ataxia type 6 (SCA6), the authors surveyed 25 patients and 25 age-matched controls with the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). The ESS was higher in patients with SCA6 (9.12 +/- 5.80; CI: 2.28) than in con...


    pub_type: 杂志文章


    authors: Howell MJ,Mahowald MW,Gomez CM

    更新日期:2006-05-09 00:00:00

  • Ethylene oxide polyneuropathy.

    abstract::Sensorimotor polyneuropathy developed in two workers who had been exposed to ethylene oxide gas repeatedly for several months. Sural nerve biopsies revealed axonal degeneration with mild changes of the myelin sheath. Unmyelinated fibers were also involved. Muscle biopsies showed typical denervation atrophy. Symptoms i...


    pub_type: 杂志文章


    authors: Kuzuhara S,Kanazawa I,Nakanishi T,Egashira T

    更新日期:1983-03-01 00:00:00

  • Dystrophin expression and somatic reversion in prednisone-treated and untreated Duchenne dystrophy. CIDD Study Group.

    abstract::The mechanism by which prednisone improves muscle strength and function in Duchenne muscular dystrophy (DMD) is unknown. We addressed the possibility that clinical improvement was related to prednisone-induced alterations in skeletal muscle dystrophin. We performed muscle biopsies on patients at the conclusion of a ra...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burrow KL,Coovert DD,Klein CJ,Bulman DE,Kissel JT,Rammohan KW,Burghes AH,Mendell JR

    更新日期:1991-05-01 00:00:00

  • Subacute combined degeneration of the spinal cord with cystinuria.

    abstract::An 18-year-old man had noticed increasing difficulty in walking for 4 years. Examination disclosed spastic paraparesis and posterior column signs suggestive of subacute combined degeneration of the spinal cord. Urinalysis, urinary thin-layer chromatography, and intestinal biopsy disclosed typical cystinuria. Perniciou...


    pub_type: 杂志文章


    authors: De Myer W,Gebhard RL

    更新日期:1975-10-01 00:00:00

  • Comparison of sensory testing on different toe surfaces: implications for neuropathy screening.

    abstract::Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...


    pub_type: 临床试验,杂志文章


    authors: Dimitrakoudis D,Bril V

    更新日期:2002-08-27 00:00:00

  • Lyme borreliosis in Bell's palsy. Long Island Neuroborreliosis Collaborative Study Group.

    abstract::Lyme borreliosis (LB) causes a range of neurologic manifestations, the most common of which is facial nerve paralysis. To evaluate nervous system LB, we organized a neurologic collaborative study group in Suffolk County, NY, a region of high LB incidence. Between July and September 1989, LB serologies were performed o...


    pub_type: 杂志文章


    authors: Halperin JJ,Golightly M

    更新日期:1992-07-01 00:00:00