Evaluation of a commercial radiochromatography module as an arterial blood activity monitor.

Abstract:

:Input functions required for positron emission tomography (PET) tracer kinetic modeling are often obtained from arterial blood. In some situations, using short-lived radiotracers, e.g. [(15)O]water, rapid sample handling is required. A method used at several facilities is to pump blood through a detector system at a constant rate. We investigate the suitability of a commercial radiochromatography module (IN/US Posi-RAM) for this new use. The Posi-RAM consists of two 2.5 cm (length) x 2.5 cm (diameter) cylindrical bismuth germanate (BGO) detectors that can operate in coincidence mode. Arterial blood is transported through the system via a length of tubing with flow rate controlled by a peristalsis pump. A custom-counting loop and support frame were designed for the Posi-RAM for PET studies. System sensitivity was determined to be 1.1 x 10(4) cps/(MBq ml(-1)). Dead time as a function of count-rate was found to be less than 1% for concentrations below 3.5 MBq ml(-1), a range encompassing all human-study values. In a human study, the performance of the device was found to be similar to that of the facility's current blood monitor (Siemens Fluid Monitor). We conclude that the Posi-RAM has the necessary sensitivity and count-rate capabilities to be used as a real-time blood activity monitor.

journal_name

Phys Med Biol

authors

Laymon CM,Sashin D,Carney JP,Ruszkiewicz J,Altenburger D,Becker CR,Lopresti BJ,Mason NS,Mountz JM,Price JC,Schavey R,Mathis CA

doi

10.1088/0031-9155/53/2/003

subject

Has Abstract

pub_date

2008-01-21 00:00:00

pages

339-51

issue

2

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(08)60623-5

journal_volume

53

pub_type

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