The role of graft and host accommodation in a hamster-to-rat cardiac transplantation model.

abstract：INTRODUCTION:The importance of HLA matching for renal transplantation outcomes has been appreciated for several decades. It has been hypothesized that as pharmacologic immunosuppression becomes stronger and more specific, the impact of HLA matching may be vanishing. Mycophenolate Mofetil (MMF) has been demonstrated to ...

journal_title：Transplantation

authors： Meier-Kriesche HU,Ojo AO,Leichtman AB,Magee JC,Rudich SM,Hanson JA,Cibrik DM,Kaplan B

更新日期：2001-02-15 00:00:00

abstract：:We report the largest single-center experience with extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) and recurrent acute rejection (AR) after lung transplantation. Lung transplant recipients undergoing ECP for BOS and recurrent AR were included (1997-2007). The rate of forced expiratory v...

journal_title：Transplantation

authors： Benden C,Speich R,Hofbauer GF,Irani S,Eich-Wanger C,Russi EW,Weder W,Boehler A

更新日期：2008-12-15 00:00:00

abstract：:We present a case report of a pediatric orthotopic liver transplant recipient who developed lymphoma with hypercalcemia on cyclosporine and prednisone immunosuppression. This is the first reported posttransplant lymphoproliferative disorder complicated by hypercalcemia, with a finding of an elevated 1,25 dihydroxyl vi...

journal_title：Transplantation

authors： Nakazato P,Esquivel CO,Urbach AH,Makowka L,Scantlebury V,Jaffe R,Starzl TE

更新日期：1989-12-01 00:00:00

abstract：:The stability of HLA alloantibodies was studied in 128 antibody-positive, potential kidney transplant recipients over an average period of 3 years. Antibody detection was performed using an anti-human globulin-complement-dependent cytotoxicity technique. In this study, the specificity of antibodies was categorized as ...

journal_title：Transplantation

authors： Rodey GE,Revels K,Fuller TC

更新日期：1997-03-27 00:00:00

abstract：BACKGROUND:The role of natural killer (NK) cells and macrophages (Møs) in the absence of T cell immunity in discordant xenograft (xg) rejection was investigated. METHODS:Guinea pig hearts were transplanted into athymic nude rats receiving no treatment or antixenoantibody (xAb), anticomplement (C), antinatural killer (...

journal_title：Transplantation

authors： Xia G,Ji P,Rutgeerts O,Waer M

更新日期：2000-07-15 00:00:00

abstract：BACKGROUND:It is important to develop new immunosuppressive agents without clinical drawbacks. In this article, we reveal the possibility of a chemically synthetic sulfonolipid that acts as a novel immunosuppressive drug. METHODS:We evaluated the immunosuppressive effect of 3-O-(6-deoxy-6-sulfono-beta-D-glucopyranosyl...

journal_title：Transplantation

authors： Matsumoto Y,Sahara H,Fujita T,Shimozawa K,Takenouchi M,Torigoe T,Hanashima S,Yamazaki T,Takahashi S,Sugawara F,Mizushina Y,Ohta K,Takahashi N,Gasa S,Jimbow K,Sakaguchi K,Sato N

更新日期：2002-07-27 00:00:00

abstract：:LEW rats (RT1l) that are lethally irradiated and repopulated with syngenic bone marrow accept WF (RT1u) cardiac allografts. If bone marrow repopulation is delayed for two days after irradiation and operation, grafts containing passenger leukocytes (nonperfused grafts) are generally rejected, but perfused grafts, which...

journal_title：Transplantation

authors： Hartnett LC,Dittmer JE,Schwadron RB

更新日期：1984-04-01 00:00:00

abstract：:Whole-body irradiation has been extensively used to ablate immune responsiveness in rodent recipients in adoptive allograft assays. This study was undertaken to determine the relative radioresistance and the tempo of regeneration, following whole-body irradiation, of cells involved in the allograft response. Six disti...

journal_title：Transplantation

authors： Farnsworth A,Wotherspoon JS,Dorsch SE

更新日期：1988-09-01 00:00:00

abstract：:In vivo cell-mediated effector mechanisms of allograft destruction were investigated in a canine single-lung transplantation model. This large animal model permits direct longitudinal studies of immune effector cells from the grafts of individual recipients by bronchoalveolar lavage (BAL). Evidence was obtained that t...

journal_title：Transplantation

authors： Norin AJ,Kamholz SL

更新日期：1989-11-01 00:00:00

abstract：:A 55-year-old woman underwent orthotopic liver transplantation for autoimmune chronic active hepatitis. Extensive portal and superior mesenteric venous thrombosis precluded standard portal venous reconstruction and necessitated use of a venous conduit from the recipient splenic vein of the donor liver. Flow through th...

journal_title：Transplantation

authors： Neelamekam TK,Geoghegan JG,Curry M,Hegarty JE,Traynor O,McEntee GP

更新日期：1997-04-15 00:00:00

abstract：:The optimal timing of administration of free radical scavengers in lung preservation has yet to be determined. In previous studies, the oxygen free radical scavenger dimethylthiourea (DMTU) has improved pulmonary function when added to Eurocollins flush solution at the time of lung harvest and infused at the time of l...

journal_title：Transplantation

authors： Lambert CJ Jr,Egan TM

更新日期：1992-08-01 00:00:00

abstract：:The pig has been considered unsuitable for experimental pancreatic transplantation. In order to develop a model for segmental transplantation, the vascular anatomy was studied in 41 pigs. No variation in venous drainage of the pancrease was found. In contrast, 3 variations of arterial supply were noted. In 29 of the p...

journal_title：Transplantation

authors： Shokouh-Amiri MH,Rahimi-Saber S,Andersen HO

更新日期：1989-01-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a major pathogen in transplant recipients and AIDS patients, and the virus may also play a role in allograft rejection. Previous work from this laboratory demonstrated increased cell surface expression of the adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) following CMV infection in vitro. W...

journal_title：Transplantation

authors： Craigen JL,Grundy JE

更新日期：1996-10-27 00:00:00

abstract：:A patient with short gut syndrome presented with end-stage liver disease. She underwent an isolated liver transplantation at the age of 3.5 years. Parenteral nutrition was discontinued 1.5 years after surgery. At 7 years of age, the patient has maintained normal nutritional indices and growth while on a normal oral di...

journal_title：Transplantation

authors： Gottrand F,Michaud L,Bonnevalle M,Dubar G,Pruvot FR,Turck D

更新日期：1999-02-27 00:00:00

abstract：BACKGROUND:We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS). METHODS:A total of 70 patients with HCC (mean age: 54.4+/-7 years, female/male: 12/58) were transplanted and included in the study. Immunosuppression ...

journal_title：Transplantation

authors： Toso C,Meeberg GA,Bigam DL,Oberholzer J,Shapiro AM,Gutfreund K,Ma MM,Mason AL,Wong WW,Bain VG,Kneteman NM

更新日期：2007-05-15 00:00:00

abstract：:Hepatic artery thrombosis (HAT) after liver transplantation (LTx) usually mandates retransplantation. Prolonged preservation with Eurocollins solution has been associated with HAT. We reviewed our experience with 359 LTx patients to identify risk factors for HAT. All grafts were preserved in University of Wisconsin so...

journal_title：Transplantation

authors： Mor E,Schwartz ME,Sheiner PA,Menesses P,Hytiroglou P,Emre S,Kishikawa K,Chiodini S,Miller CM

更新日期：1993-12-01 00:00:00

abstract：:The mixed lymphocyte culture tests between one patient with acute lymphocytic leukemia and her mother and between another patient with aplastic anemia and his mother were found nonreactive, despite a one-haplotype difference for HL-A. Two crossovers in each family at the MLC locus or a specific defect in lymphocyte r...

journal_title：Transplantation

authors： Opelz G

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The present study was undertaken to determine whether anti-complement 5 (C5) monoclonal antibodies (mAb) prevent hyperacute rejection (HAR) in a rat-to-presensitized mouse heart transplantation model and whether these mAb, combined with cyclosporine (CsA) and cyclophosphamide (CyP), can achieve long-term gra...

journal_title：Transplantation

authors： Wang H,Rollins SA,Gao Z,Garcia B,Zhang Z,Xing J,Li L,Kellersmann R,Matis LA,Zhong R

更新日期：1999-12-15 00:00:00

abstract：:Human herpesvirus type 6 (HHV-6) causes roseola infantum (exanthema subitum) upon primary infection in young children. Thereafter it persists lifelong in the organism. Like other herpesviruses, HHV-6 can be reactivated in periods of immunosuppression - e.g., after organ transplantation. In order to study the incidence...

journal_title：Transplantation

authors： Schmidt CA,Wilbron F,Weiss K,Brinkmann V,Oettle H,Lohmann R,Langrehr JM,Neuhaus P,Siegert W

更新日期：1996-02-27 00:00:00

abstract：BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...

journal_title：Transplantation

authors： Coll E,Torre-Cisneros J,Calvo R,Garrido G,Matesanz R

更新日期：2013-07-27 00:00:00

abstract：:Alloreactive T cells are often specific for individual peptides that are bound to allogeneic major histocompatibility complex (MHC) molecules. Other alloreactive T cells are reported to be peptide-independent or to recognize MHC conformational changes that are induced by multiple peptides. We tested 12 anti-HLA-B7 all...

journal_title：Transplantation

authors： Smith KD,Huczko E,Engelhard VH,Li YY,Lutz CT

更新日期：1997-07-27 00:00:00

abstract：:Flow cytometry (FC) T and B cell crossmatches were done retrospectively for 38 cadaver renal transplant recipients (29 first and 9 retransplants--minimum follow-up 12 months) using both current pretransplant serum and peak-reactive sera. An increase in median fluorescence intensity (channel shift) and/or an increase i...

journal_title：Transplantation

authors： Lazda VA,Pollak R,Mozes MF,Jonasson O

更新日期：1988-03-01 00:00:00

abstract：:In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, th...

journal_title：Transplantation

authors： Storek J,Joseph A,Dawson MA,Douek DC,Storer B,Maloney DG

更新日期：2002-04-15 00:00:00

abstract：BACKGROUND:Evidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation. METHODS:This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, a...

journal_title：Transplantation

authors： Dobbels F,Vanhaecke J,Desmyttere A,Dupont L,Nevens F,De Geest S

更新日期：2005-06-15 00:00:00

abstract：INTRODUCTION:This study examines the efficacy and toxicity of sirolimus used as primary immunosuppression in combination with reduced dose tacrolimus (calcineurin inhibitor [CI]-sparing regimen) or mycophenolate mofetil (CI-free regimen) in high-risk cadaveric renal transplantation. METHODS:Seventy subjects were treat...

journal_title：Transplantation

authors： Lo A,Egidi MF,Gaber LW,Amiri HS,Vera S,Nezakatgoo N,Gaber AO

更新日期：2004-04-27 00:00:00

abstract：:Class I molecules of the MHC affect target cell sensitivity to NK cell repertoire. In the mouse, absence of MHC class I molecules on target cells is associated with an increased susceptibility to NK cell-mediated lysis, while syngeneic class I molecules confer protection. In contrast to the protective role of syngenei...

journal_title：Transplantation

authors： Salcedo M,Höglund P,Ljunggren HG

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Knowledge on the reinnervation of transplanted organs is scarce, and the aim of the study was therefore to evaluate to what degree syngeneic pancreas grafts were reinnervated in rats. METHODS:Syngeneic pancreatico-duodenal transplantations were performed in normoglycemic Wistar-Furth rats. Native and transp...

journal_title：Transplantation

authors： Korsgren O,Jansson L,Ekblad E,Sundler F

更新日期：2001-01-15 00:00:00

abstract：BACKGROUND:Gene targeting in large animals has the potential to be useful in medicine as well as in agriculture. Previously, we reported the first successful targeting of the bovine alpha1,3-galactosyltransferase (alpha1,3GT) gene and establishment of a heterozygous knockout cell line. In this report, we generated both...

journal_title：Transplantation

authors： Sendai Y,Sawada T,Urakawa M,Shinkai Y,Kubota K,Hoshi H,Aoyagi Y

更新日期：2006-03-15 00:00:00

abstract：:Published data on the guinea pig-to-rat hepatic xenotransplant model describe problems concerning poor graft reperfusion. To further investigate this phenomenon, orthotopic liver xenotransplantation between weight-matched guinea pigs and rats were performed using Kamada's technique. On reperfusion, all cases had porta...

journal_title：Transplantation

authors： Delriviere LD,Havaux X,Gibbs P,Gianello PR

更新日期：1998-07-15 00:00:00

abstract：:The potential role of donor's mature T lymphocytes on the recovery of various immunological functions and hematopoiesis was investigated in lethally irradiated BALB/c mice by studying reconstitution with normal, as compared with T-cell-depleted, syngeneic marrow grafts. Recovery of total, as well as mononuclear, perip...

journal_title：Transplantation

authors： Shalit M,Ayalon M,Weiss L,Leshem B,Kedar E,Slavin S

更新日期：1986-08-01 00:00:00