Abstract:
:MALDI-MS is an extremely flexible technique and can be synergistically used in conjunction with established bioanalytical methods such as PAGE or SPR. To that end, slight modifications on the sample target plate may be necessary. Those can involve the use of hydrophobic coatings for improved sample deposition and desalting or that of sensor surfaces for on-target bioaffinity experiments. In particular the latter have evolved considerably over the past years. Surface coatings using polysaccharide or polycarboxylate hydrogels were adopted from unrelated techniques and they proved very suitable for bioaffinity MS. The developments concerning target modification and derivatization are reviewed.
journal_name
Proteomicsjournal_title
Proteomicsauthors
König Sdoi
10.1002/pmic.200700782subject
Has Abstractpub_date
2008-02-01 00:00:00pages
706-14issue
4eissn
1615-9853issn
1615-9861journal_volume
8pub_type
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