Optimal method of collection of first-void urine for diagnosis of Chlamydia trachomatis infection in men.

Abstract:

:First-void urine (FVU) is the preferred specimen for the diagnosis of urogenital Chlamydia trachomatis infection in men. We have developed FirstBurst, a urine collection device that collects the first 4 to 5 ml of FVU and yields a specimen with a sixfold higher C. trachomatis organism load than the regular urine cup by quantitative PCR (32,533 versus 5,271 plasmids/ml; P < 0.0001). Consequently, the use of FirstBurst to collect a urine sample improved the sensitivity of a rapid test for Chlamydia over testing of samples collected with a urine cup (82 versus 47% sensitivity using PCR as a reference; P < 0.0015).

journal_name

J Clin Microbiol

authors

Wisniewski CA,White JA,Michel CE,Mahilum-Tapay L,Magbanua JP,Nadala EC Jr,Barber PJ,Goh BT,Lee HH

doi

10.1128/JCM.02241-07

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

1466-9

issue

4

eissn

0095-1137

issn

1098-660X

pii

JCM.02241-07

journal_volume

46

pub_type

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