Abstract:
:We report the clinical course of a 4-year-old girl with chronic cerebellitis (onset 2 days after diphtheria-pertussis-tetanus vaccination at 1 year and 7 months old) associated with anti-glutamate receptor delta 2 antibody, who improved dramatically with steroid therapy (methylprednisolone pulse therapy plus oral prednisolone). Recently, it has been reported that the anti-glutamate receptor delta 2 selectively expressed at the post-synaptic site of parallel fiber-Purkinje cell synapses has an important role in cerebellar function in the developing brain. The present case suggests that anti-glutamate receptor delta 2 antibody plays a primary role in an immune-mediated process causing chronic cerebellar symptoms, and the lesion site seems to be localized to the parallel fiber-Purkinje cell synapse. Because the cerebellum is strongly involved in language acquisition as well as motor development, treatment must facilitate time for language learning while reducing the side effects of the corticosteroid therapy.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Kubota M,Takahashi Ydoi
10.1177/0883073807307973subject
Has Abstractpub_date
2008-02-01 00:00:00pages
228-30issue
2eissn
0883-0738issn
1708-8283pii
23/2/228journal_volume
23pub_type
杂志文章abstract::Recently described, the congenital Zika syndrome caused by the Zika virus has many features of other congenital infections. This case series study reports 22 infants with congenital Zika syndrome in Brazil who developed infantile spasms during their first year of life. The median age of infantile spasms onset was 4.3 ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818780105
更新日期:2018-09-01 00:00:00
abstract::A 16-year-old galactosemic patient, homozygous for the 5.5-kb gene deletion, suffered severe neurologic regression following streptococcal infection. Since the gene deletion includes the promoter of interleukin-11a receptor involved in neuronal apoptosis, we questioned whether this patient had no interleukin-11a recep...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814540520
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Acute flaccid myelitis has emerged as the leading cause of acute flaccid paralysis in children. Acute flaccid myelitis leads to significant physical disability; hence, objective outcome measures to study disease severity and progression are desirable. In addition, nerve transfer to improve motor function in ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820939392
更新日期:2020-11-01 00:00:00
abstract::The objective of this study is to determine the long-term outcome of children with intractable epilepsy who have diffuse cortical hypometabolism on 2-deoxy-2-((18)F)fluoro-D-glucose positron emission tomography (FDG-PET) scans. Seventeen children with intractable epilepsy showing bilateral, diffuse cortical hypometabo...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811416363
更新日期:2012-01-01 00:00:00
abstract::Neuromotor function was assessed in 94 children of normal intelligence with Tourette syndrome, Tourette syndrome and attention-deficit hyperactivity disorder (ADHD), or ADHD only, using the Physical and Neurological Examination of Subtle Signs (PANESS). Time to complete six motor movements was analyzed separately by s...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389701200705
更新日期:1997-10-01 00:00:00
abstract::This study was performed to determine the utility of 99mTc-hexamethylpropylenamine oxime (HMPAO) brain single photon emission computed tomography (SPECT) in evaluating patients with childhood absence epilepsy. Twenty-three patients (13 female, 10 male), aged 7 to 15 years (mean age 10.3 +/- 2.2), were studied. All pat...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738030180080401
更新日期:2003-08-01 00:00:00
abstract::Lissencephaly is a brain malformation manifested by a smooth cerebral surface and caused by incomplete neuronal migration. Clinical sequellae include minor craniofacial changes (bitemporal hollowing, small jaw), severe mental retardation, and other neurological abnormalities. Patients with classical or type I lissence...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389000500113
更新日期:1990-01-01 00:00:00
abstract::Muscular dystrophies are composed of a variety of genetic muscle disorders linked to different chromosomes and loci and associated with different gene mutations that lead to progressive muscle atrophy and weakness. Fukuyama congenital muscular dystrophy is frequently associated with partial and generalized epilepsy an...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738060210021601
更新日期:2006-02-01 00:00:00
abstract::Retinoblastoma is the most common primary intraocular malignancy of childhood. It typically presents with leukocoria or strabismus. In later stages of the disease, the child may exhibit proptosis, buphthalmos, or hypopyon. The pathognomonic molecular aberration is a loss of function mutation in the RB1 gene on chromos...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073815587943
更新日期:2016-02-01 00:00:00
abstract::The purpose of this study was to assess the cognitive development of 27 children with nonhemorrhagic neonatal stroke (occurring within the first 28 days of life). The cognitive evaluation consisted of the Bayley Scales of Infant Development, administered at 12 and/or 24 months poststroke. Compared with the normative s...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807305784
更新日期:2007-09-01 00:00:00
abstract::We analyzed, retrospectively, 92 patients with headache to determine the changes in the order of frequency of causes with the development of neuroimaging studies and its efficacy in the investigation of patients with headache. The type of headache was redefined according to the International Headache Society (IHS) dia...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389801300502
更新日期:1998-05-01 00:00:00
abstract::Patients with refractory seizures, including those with Sturge-Weber syndrome, undergo functional studies in preparation for surgery. Perfusion studies in Sturge-Weber syndrome by single photon emission computed tomography and positron emission tomography generally demonstrate hypoperfusion in the diseased tissue. We ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807302597
更新日期:2007-05-01 00:00:00
abstract::Four unrelated infants with neonatal thrombocytopenia associated with congenital blindness and porencephaly have been seen over an 18-year period. The association of congenital blindness with neonatal thrombocytopenia has not previously been reported. All children had clinical purpura in the neonatal period; in three ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388800300208
更新日期:1988-04-01 00:00:00
abstract::Actinopathies are defined by missense mutations in the ACTA1 gene coding for sarcomeric actin, of which some 70 families have, so far, been identified. Often, but not always, muscle fibers carry large patches of actin filaments. Many such patients also have nemaline myopathy, qualifying actinopathies as a subgroup of ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738040190021201
更新日期:2004-02-01 00:00:00
abstract::Elevation and blur of the optic disc margin with hyperemia and flame hemorrhages are classic features of papilledema that may not be present with mild elevations of the cerebral spinal fluid pressure. In children, the disc can be dramatically elevated with indistinct margins in pseudopapilledema. Children with equivoc...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807304192
更新日期:2007-07-01 00:00:00
abstract::Autism is etiologically heterogeneous; medical conditions are implicated in only a minority of cases, whereas metabolic disorders are even less common. Recently, there have been articles describing the association of autism with mitochondrial abnormalities. We critically review the current literature and conclude that...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307380401900510
更新日期:2004-05-01 00:00:00
abstract::Vibratory feedback can be a useful tool for rehabilitation. We examined its use in children with dystonia to understand how it affects muscle activity in a population that does not respond well to standard rehabilitation. We predicted scaled vibration (ie, vibration that was directly or inversely proportional to muscl...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073816671830
更新日期:2017-02-01 00:00:00
abstract::The aim of the present study was to assess the emotional and cognitive aspects of social cognition among patients with rolandic epilepsy. A computerized neuropsychological battery was used for cognitive evaluation. Affective and cognitive social cognition were evaluated using two computerized Theory of Mind tasks. Cog...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811414420
更新日期:2012-02-01 00:00:00
abstract::Pontine tegmental cap dysplasia is a rare hindbrain malformation syndrome with a hypoplastic pons, a tissue protrusion into the fourth ventricle, and cranial nerve dysfunction. We here report clinical, imaging, and genetic findings of the first extremely low-birth-weight preterm infant with pontine tegmental cap dyspl...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073816680748
更新日期:2017-03-01 00:00:00
abstract::Neural tube defects are common birth defects, the frequency of which appears to be reduced by maternal supplementation and/or fortification of folic acid. Latin Americans have a high incidence of neural tube defects. We surveyed the dietary intake of Honduran women of childbearing age using a 24-hour dietary recall qu...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700506
更新日期:2002-05-01 00:00:00
abstract::In lieu of traditional training of examiners to identify cerebral palsy on a neurologic examination at age 1 year, we proposed an alternative approach using a multimedia training video and CD-ROM we developed after a two-step validation process. We hypothesized that use of CD-ROM interactive training will lead to reli...
journal_title:Journal of child neurology
pub_type: 杂志文章,多中心研究
doi:10.1177/08830738050200101001
更新日期:2005-10-01 00:00:00
abstract::Although long-term follow-up data are available for cases with acute disseminated encephalomyelitis, the findings range widely because of the lack of consistent definitions. Using the International Pediatric Multiple Sclerosis Study Group definitions strictly, we determined the long-term prognosis of children with acu...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809343320
更新日期:2010-06-01 00:00:00
abstract::Adolescence is an important period, marked by significant changes in biological and psychosocial domains. Epilepsy is a chronic neurologic disorder associated with social stigma and prejudice. The etiology of depression in epilepsy appears to be a complex interplay between psychosocial and neurobiologic factors. This ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820954060
更新日期:2021-02-01 00:00:00
abstract::Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813520500
更新日期:2015-01-01 00:00:00
abstract::Seven children with neuromuscular disease were placed on mechanical ventilation before the age of 2 years. The outcome for these patients was variable and did not correlate with primary diagnosis. There appeared to be a high correlation between the incidence of electrocardiogram changes and death. Our experience demon...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388800300106
更新日期:1988-01-01 00:00:00
abstract::There is strong evidence for a loss of habituation during cognitive processing in migraine as measured by P300 and contingent negative variation in adults. Event-related potentials evoked by an oddball paradigm have not yet been studied in children and adolescents suffering from different primary headache types. We re...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389801300703
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:We performed a retrospective chart review of patients with trisomy 21 and infantile spasms in our university-based pediatric epilepsy center between 2002 and 2016 in order to describe the clinical characteristics of children with these diagnoses as well as to evaluate their response to first-line treatments. ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073819850650
更新日期:2019-10-01 00:00:00
abstract::Discrimination of odorous molecules in amniotic fluid occur after 30 weeks' gestation; fetuses exhibit differential responses to maternal diet. Olfactory reflexes enable reliable neonatal testing. Olfactory bulbs can be demonstrated reliably by MRI after 30 weeks' gestation, and their hypoplasia or aplasia also docume...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073817690867
更新日期:2017-05-01 00:00:00
abstract::We report a divergent ependymal tumor of the posterior fossa (ependymoblastoma/anaplastic ependymoma) observed in an 8-year-old boy. The tumor showed the histological pattern typical of an ependymoblastoma (tubular-papillary fetaloid architecture with stratification of the tumor cells) next to areas in which findings ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808314160
更新日期:2008-09-01 00:00:00
abstract::This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. This was a randomized, double-blind study of riboflavin (200 mg daily) versus placebo in 48 children. The primary efficacy measure was the number of patients achieving a 50% or greater reduction in the number of migrai...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/0883073808318053
更新日期:2008-11-01 00:00:00