Abstract:
:Production of various structures by self-assembling single stranded DNA molecules is a widely used technology in the filed of DNA nanotechnology. Base sequences of single strands do predict the shape of the resulting nanostructure. Therefore, sequence design is crucial for the successful structure fabrication. This paper presents a sequence design algorithm based on mismatch minimization that can be applied to every desired DNA structure. With this algorithm, junctions, loops, single as well as double stranded regions, and very large structures up to several thousand base pairs can be handled. Thereby, the algorithm is fast for the most structures. Algorithm is Java-implemented. Its implementation is called Seed and is available publicly. As an example for a successful sequence generation, this paper presents the fabrication of DNA chain molecules consisting of double-crossover (DX) tiles as well.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Seiffert J,Huhle Adoi
10.1080/07391102.2008.10507193subject
Has Abstractpub_date
2008-04-01 00:00:00pages
453-66issue
5eissn
0739-1102issn
1538-0254pii
d=3031&c=4251&p=16419&do=detailjournal_volume
25pub_type
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