当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish.

Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish.

Abstract：

:Due to its unique physicochemical and optical properties, C60 has raised interest in commercialization for a variety of products. While several reports have determined this nanomaterial to act as a powerful antioxidant, many other studies have demonstrated a strong oxidative potential through photoactivation. To directly address the oxidative potential of C60, the effects of light and chemical supplementation and depletion of glutathione (GSH) on C60-induced toxicity were evaluated. Embryonic zebrafish were used as a model organism to examine the potential of C60 to elicit oxidative stress responses. Reduced light during C60 exposure significantly decreased mortality and the incidence of fin malformations and pericardial edema at 200 and 300 ppb C60. Embryos co-exposed to the glutathione precursor, N-acetylcysteine (NAC), also showed reduced mortality and pericardial edema; however, fin malformations were not reduced. Conversely, co-exposure to the GSH synthesis inhibitors, buthionine sulfoximine (BSO) and diethyl maleate (DEM), increased the sensitivity of zebrafish to C60 exposure. Co-exposure of C60 or its hydroxylated derivative, C60(OH)(24), with H2O2 resulted in increased mortality along the concentration gradient of H2O2 for both materials. Microarrays were used to examine the effects of C60 on the global gene expression at two time points, 36 and 48 h post fertilization (hpf). At both life stages there were alterations in the expression of several key stress response genes including glutathione-S-transferase, glutamate cysteine ligase, ferritin, alpha-tocopherol transport protein and heat shock protein 70. These results support the hypothesis that C60 induces oxidative stress in this model system.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Usenko CY,Harper SL,Tanguay RL

doi

10.1016/j.taap.2007.12.030

subject

Has Abstract

pub_date

2008-05-15 00:00:00

pages

44-55

issue

1

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(08)00005-7

journal_volume

229

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Combined use of vitamin E and nimodipine ameliorates dibutyl phthalate-induced memory deficit and apoptosis in mice by inhibiting the ERK 1/2 pathway.

    abstract：:Learning disabilities (LDs) in children are a serious global problem. Dibutyl phthalate (DBP), a plasticizer widely used in daily life, has been linked to triggering childhood LDs, however the mechanism underlying this remains unclear. Studies have shown that the ERK 1/2 pathway is closely related to apoptosis of hipp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2019.02.008

    authors： Yan B,Sun Y,Zeng J,Chen Y,Li C,Song P,Zhang L,Yang X,Wu Y,Ma P

    更新日期：2019-04-01 00:00:00

  • The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease.

    abstract：:Isoflurane is known to increase β-amyloid aggregation and neuronal damage. We hypothesized that isoflurane will have similar effects on the polyglutamine huntingtin protein and will cause alterations in intracellular calcium homeostasis. We tested this hypothesis in striatal cells from the expanded glutamine huntingti...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.10.032

    authors： Wang Q,Liang G,Yang H,Wang S,Eckenhoff MF,Wei H

    更新日期：2011-02-01 00:00:00

  • Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.

    abstract：:Two members of the cytochrome P450 2A subfamily, CYP2A10 and 2A11, are abundant nasal enzymes previously characterized in rabbit olfactory microsomes. Rabbit CYP2A is active toward a number of nasal toxicants, including the rat nasal procarcinogen hexamethylphosphoramide (HMPA). While P450s immunochemically related to...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.7975

    authors： Thornton-Manning JR,Nikula KJ,Hotchkiss JA,Avila KJ,Rohrbacher KD,Ding X,Dahl AR

    更新日期：1997-01-01 00:00:00

  • Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis.

    abstract：:Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, whi...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.07.001

    authors： Pogribny IP,Bagnyukova TV,Tryndyak VP,Muskhelishvili L,Rodriguez-Juarez R,Kovalchuk O,Han T,Fuscoe JC,Ross SA,Beland FA

    更新日期：2007-11-15 00:00:00

  • Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR-γ and subsequent expression of HGF in colons.

    abstract：:Berberine has been demonstrated to alleviate renal interstitial, liver and myocardial fibrosis when administered orally despite its extremely low bioavailability. Here, we inspected effect of berberine on pulmonary fibrosis (PF) and explored underlying mechanisms on the basis of intestinal endocrine. The results showe...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2018.02.001

    authors： Guan C,Qiao S,Lv Q,Cao N,Wang K,Dai Y,Wei Z

    更新日期：2018-03-15 00:00:00

  • Kisspeptin-52 partially rescues the activity of the hypothalamus-pituitary-gonadal axis in underweight male rats dosed with an anti-obesity compound.

    abstract：:Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes mediated through the intended drug-induced weight loss from direct d...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.115152

    authors： Bolze F,Williams H,Bhuwania R,Egecioglu E,Bloem E,Paulsson JF,Pedersen MØ,Broadmeadow A,Chesher CJ,Moore EL,Skydsgaard M,Galle PS,Dalgaard M,Wulff BS,Tena-Sempere M,Andersen LW

    更新日期：2020-10-01 00:00:00

  • Zinc oxide nanoparticles and monocytes: impact of size, charge and solubility on activation status.

    abstract：:Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. ZnO nanoparticles (NP; average diameter 70nm) were more toxic than the bulk form (<44μm mesh) and a positive charge ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.10.020

    authors： Prach M,Stone V,Proudfoot L

    更新日期：2013-01-01 00:00:00

  • Carcinogenicity of formaldehyde and hydrogen chloride in rats.

    abstract：:Previous studies in this laboratory have shown that the combined exposure of hydrogen chloride (HCI) and formaldehyde vapors (HCHO) elicited a significant incidence of nasal cancer in rats. In studies performed elsewhere, it has been demonstrated that exposure to formaldehyde alone induced a high nasal cancer response...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90411-9

    authors： Sellakumar AR,Snyder CA,Solomon JJ,Albert RE

    更新日期：1985-12-01 00:00:00

  • Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat.

    abstract：:The disposition of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), a highly toxic environmental contaminant which accumulates in human tissues, was examined in the male Fischer rat after iv and oral exposure. Greater than 70% of an oral dose of 0.1, 0.5, or 1.0 mumol PeCDF/kg body wt was absorbed by the gastrointestinal sy...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90332-2

    authors： Brewster DW,Birnbaum LS

    更新日期：1987-09-15 00:00:00

  • Developmental programming: impact of prenatal exposure to bisphenol-A and methoxychlor on steroid feedbacks in sheep.

    abstract：:Bisphenol-A (BPA), a polymer used in plastics manufacturing, and methoxychlor (MXC), a pesticide, are endocrine disrupting compounds with estrogenic and anti-androgenic properties. Prenatal BPA or MXC treatment induces reproductive defects in sheep with BPA causing prepubertal luteinizing hormone (LH) hypersecretion a...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2013.02.011

    authors： Abi Salloum B,Steckler TL,Herkimer C,Lee JS,Padmanabhan V

    更新日期：2013-05-01 00:00:00

  • Effect of cadmium on plasma aldosterone and serum corticosterone concentrations in male rats.

    abstract：:Cadmium chloride (CdCl2) at a dose of 1 mg/kg of body weight was injected into male Wistar rats twice a day (12-hr intervals) for 7 consecutive days. A group of treated rats was maintained without any treatment for an additional period of 10 days and killed on the following day (on Day 18). Plasma aldosterone concentr...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(84)90346-6

    authors： Nishiyama S,Nakamura K

    更新日期：1984-12-01 00:00:00

  • Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells.

    abstract：:Cadmium (Cd) is a common environmental toxicant and an established carcinogen. Epidemiological studies implicate Cd with human breast cancer. Low micromolar concentrations of Cd promote proliferation of human breast cancer cells in vitro. The growth promotion of breast cancer cells is associated with the activation of...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.05.010

    authors： Song X,Wei Z,Shaikh ZA

    更新日期：2015-08-15 00:00:00

  • The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls.

    abstract：:Aroclor 1254 and fireMaster BP-6, two commercial polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) preparations, exhibit comparable biologic and toxic effects. In the present study the commercial PBB was more active than Aroclor 1254 in causing thymic atrophy in male Wistar rats. However, a direct compa...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90096-0

    authors： Andres J,Lambert I,Robertson L,Bandiera S,Sawyer T,Lovering S,Safe S

    更新日期：1983-09-15 00:00:00

  • Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells.

    abstract：:Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated gastrointestinal inflammation. NADPH oxidase (NOX) and mitochondrial complexes (I and II) are the major sources of ROS production contributing to TNF-α/cycloheximide (CHX)-i...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2015.07.007

    authors： Babu D,Leclercq G,Goossens V,Remijsen Q,Vandenabeele P,Motterlini R,Lefebvre RA

    更新日期：2015-10-15 00:00:00

  • Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain--in vitro and ex vivo evidence.

    abstract：:Kynurenic acid (KYNA) is a recognized broad-spectrum antagonist of excitatory amino acid receptors with a particularly high affinity for the glycine co-agonist site of the N-methyl-D-aspartate (NMDA) receptor complex. KYNA is also a putative endogenous neuroprotectant. Recent studies show that KYNA strongly blocks alp...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.07.011

    authors： Zielińska E,Kuc D,Zgrajka W,Turski WA,Dekundy A

    更新日期：2009-10-15 00:00:00

  • In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line.

    abstract：:Eicosanoids released after ozone exposure of a human bronchial epithelial cell line, BEAS-S6, were analyzed by high-pressure liquid chromatography (HPLC) of supernatants from exposed cells prelabeled with [3H]arachidonic acid. BEAS cells released thromboxane B2 (TxB2), prostaglandin E2 (PGE2), leukotriene C4 (LTC4), L...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1027

    authors： McKinnon KP,Madden MC,Noah TL,Devlin RB

    更新日期：1993-02-01 00:00:00

  • High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.

    abstract：:Baicalin is a major flavonoid compound purified from Scutellariae radix, which has been described as an herb in the Chinese Pharmacopoeia. Previous studies have suggested baicalin possessed extensive anti-inflammatory, anti-cancer, anti-viral properties. However, up to known, there have been no reports of safety and t...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2017.08.003

    authors： Cai Y,Ma W,Xiao Y,Wu B,Li X,Liu F,Qiu J,Zhang G

    更新日期：2017-10-15 00:00:00

  • In utero and in vitro effects of benzene and its metabolites on erythroid differentiation and the role of reactive oxygen species.

    abstract：:Benzene is a ubiquitous occupational and environmental toxicant. Exposures to benzene both prenatally and during adulthood are associated with the development of disorders such as aplastic anemia and leukemia. Mechanisms of benzene toxicity are unknown; however, generation of reactive oxygen species (ROS) by benzene m...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.01.002

    authors： Badham HJ,Winn LM

    更新日期：2010-05-01 00:00:00

  • Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish.

    abstract：:Triclosan (TCS) is an antimicrobial agent commonly found in a variety of personal care products and cosmetics. TCS readily enters the environment through wastewater and is detected in human plasma, urine, and breast milk due to its widespread use. Studies have implicated TCS as a disruptor of thyroid and estrogen sign...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.08.013

    authors： Haggard DE,Noyes PD,Waters KM,Tanguay RL

    更新日期：2016-10-01 00:00:00

  • Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study.

    abstract：:Interference of exogenous chemicals with the aromatase enzyme can be useful as a tool to identify chemicals that could act either chemopreventive for hormone-dependent cancer or adverse endocrine disruptive. Aromatase is the key enzyme in the biosynthesis of steroids, as it converts androgens to estrogens. Certain fla...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2007.12.007

    authors： van Meeuwen JA,Nijmeijer S,Mutarapat T,Ruchirawat S,de Jong PC,Piersma AH,van den Berg M

    更新日期：2008-05-01 00:00:00

  • Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice.

    abstract：:The mechanism of liver cell injury induced by an overdose of the analgesic acetaminophen (AAP) remains controversial. Recently, it was hypothesized that a significant number of hepatocytes die by apoptosis. Since caspases have been implicated as critical signal and effector proteases in apoptosis, we investigated thei...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1999.8635

    authors： Lawson JA,Fisher MA,Simmons CA,Farhood A,Jaeschke H

    更新日期：1999-05-01 00:00:00

  • Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats.

    abstract：:During postnatal skeletal growth, adaptation to mechanical loading leads to cellular activities at the growth plate. It has recently become evident that bone forming and bone resorbing cells are affected by the receptor tyrosine kinase (RTK) inhibitor imatinib mesylate (STI571, Gleevec®). Imatinib targets PDGF, ABL-re...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.04.019

    authors： Nurmio M,Joki H,Kallio J,Määttä JA,Väänänen HK,Toppari J,Jahnukainen K,Laitala-Leinonen T

    更新日期：2011-08-01 00:00:00

  • Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats.

    abstract：:Selective cyclooxygenase-2 (COX-2) inhibitors have been shown to produce fewer gastrointestinal adverse reactions when compared with conventional nonselective nonsteroidal anti-inflammatory drugs and they suppress angiogenesis in tumors. The purpose of the present study was to investigate the effects of highly selecti...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2002.9457

    authors： Guo JS,Cho CH,Lam Liu ES,Choy HT,Wang JY,Leung Koo MW

    更新日期：2002-08-15 00:00:00

  • Mechanistic toxicogenomic analysis of WAY-144122 administration in Sprague-Dawley rats.

    abstract：:Application of global gene expression analysis in the study of mechanisms of toxicity could provide a more comprehensive interpretation of the molecular basis of drug action. WAY-144122 has pharmacological activity against several targets improving insulin responsiveness and favorably altering lipid profiles. Normal r...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2003.11.016

    authors： Peterson RL,Casciotti L,Block L,Goad ME,Tong Z,Meehan JT,Jordan RA,Vinlove MP,Markiewicz VR,Weed CA,Dorner AJ

    更新日期：2004-04-01 00:00:00

  • Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: a consequence of altered Ca2+ homeostasis.

    abstract：:The present study examined the activation of protein kinase C (PKC) and disruption of Ca2+ homeostasis as potential mechanisms underlying effects of the polychlorinated biphenyl (PCB) congener 2,2'-dichlorobiphenyl (DCB) on inositol phosphate (IP) signaling in cerebellar granule cells. DCB (100 microM) increased basal...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.0311

    authors： Shafer TJ,Mundy WR,Tilson HA,Kodavanti PR

    更新日期：1996-12-01 00:00:00

  • Dermal toxicity of ammonium perfluorooctanoate.

    abstract：:Ammonium perfluorooctanoate (CAS Registry No. 3825-26-2) is used commercially in the aqueous polymerization of fluorinated monomers. Because the chemical exists as a fine white powder which can come in contact with skin, its dermal toxicology was studied in rabbits and rats. Dermal applications of 0.5 g for 24 hr prod...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(85)90172-3

    authors： Kennedy GL Jr

    更新日期：1985-11-01 00:00:00

  • Biphasic hormonal responses to the adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE in human cells.

    abstract：:The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO(2)-DDE) has been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) treatment. ACC is a rare malignant disorder with poor prognosis, and the current pharmacological therapy o,p'-DDD (mitotane) has limited efficacy and causes severe adverse effects...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2009.10.018

    authors： Asp V,Ullerås E,Lindström V,Bergström U,Oskarsson A,Brandt I

    更新日期：2010-02-01 00:00:00

  • St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis.

    abstract：:Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for drugs such as irinotecan (CPT-11), 5-fluouracil, oxaliplatin, capecitabine and raltitrexed. St. John's wort (Hypericum perforatum, SJW) has anti-inflammatory activity, and our preliminary study in the rat and a pilot stu...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2006.05.020

    authors： Hu ZP,Yang XX,Chan SY,Xu AL,Duan W,Zhu YZ,Sheu FS,Boelsterli UA,Chan E,Zhang Q,Wang JC,Ee PL,Koh HL,Huang M,Zhou SF

    更新日期：2006-10-15 00:00:00

  • Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

    abstract：:Lung toxicity induced by sulfur mustard is associated with inflammation and oxidative stress. To elucidate mechanisms mediating pulmonary damage, we used 2-chloroethyl ethyl sulfide (CEES), a model sulfur mustard vesicant. Male mice (B6129) were treated intratracheally with CEES (3 or 6 mg/kg) or control. Animals were...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.10.027

    authors： Sunil VR,Patel-Vayas K,Shen J,Gow AJ,Laskin JD,Laskin DL

    更新日期：2011-02-01 00:00:00

  • 2,2',4,6,6'-pentachlorobiphenyl induces apoptosis in human monocytic cells.

    abstract：:Polychlorinatedbiphenyls (PCBs) are a group of persistent and widely dispersed environmental pollutants, some of which may be immunotoxic. In the present study, we investigated the effect of PCBs on immune system by assessing apoptotic cell death in human monocytic U937 cells. Among the various congeners tested, 2,2',...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.2000.9034

    authors： Shin KJ,Bae SS,Hwang YA,Seo JK,Ryu SH,Suh PG

    更新日期：2000-11-15 00:00:00