Regulation of peptidoglycan biosynthesis in relA+ and relA- strains of Escherichia coli during diauxic growth on glucose and lactose.

Abstract:

:In both relA+ and relA- derivatives, the biosynthesis of peptidoglycan, lipid intermediates, and nucleotide precursors abruptly halted at the onset of diauxic lag from glucose to lactose with a concomitant accumulation of guanosine 5'-diphosphate 3'-diphosphate (ppGpp). These results are consistent with the proposal that ppGpp is involved in inhibiting the incorporation of disaccharide-pentapeptide into peptidoglycan and in regulating nucleotide precursor synthesis.

journal_name

Can J Microbiol

authors

Ishiguro EE

doi

10.1139/m79-188

subject

Has Abstract

pub_date

1979-10-01 00:00:00

pages

1206-8

issue

10

eissn

0008-4166

issn

1480-3275

journal_volume

25

pub_type

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