Abstract:
:The murine invariant chain (Ii) was found to incorporate radioactive palmitic acid. This binding of fatty acid inhibits the formation of interchain S-S bonds, probably because the cysteine residue in the transmembrane region of the Ii chain is palmitylated. The inhibition of fatty acylation by cerulenin blocks further posttranslational maturation of the invariant chain as shown by two-dimensional gel electrophoresis of Ii immunoprecipitates. In particular, the addition of sialic acid residues is blocked. Thus, it appears that fatty acylation is essential for carbohydrate processing of the Ii chain.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Koch N,Hämmerling GJdoi
10.1021/bi00343a023subject
Has Abstractpub_date
1985-10-22 00:00:00pages
6185-90issue
22eissn
0006-2960issn
1520-4995journal_volume
24pub_type
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