Abstract:
:We have a long-standing interest in a nuclear protease which appears to be involved in carcinogenesis. We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases. HtrA1 has been classified as a secreted protease involved in TGFbeta signaling, but recent work has shown HtrA1 to be a tumor suppressor. Here we show that processed forms of HtrA1 are found intracellularly and intranuclearly, and the active intranuclear form of HtrA1 shows an approximately Mr 29,000. Further, expression of HPV E6/E7 proteins is associated with a post-transcriptional up-regulation of HtrA1 (most notably the nuclear form), and HtrA1 is found associated with both HPV E6 and E7 proteins.
journal_name
J Cell Biochemjournal_title
Journal of cellular biochemistryauthors
Clawson GA,Bui V,Xin P,Wang N,Pan Wdoi
10.1002/jcb.21804subject
Has Abstractpub_date
2008-09-01 00:00:00pages
81-8issue
1eissn
0730-2312issn
1097-4644journal_volume
105pub_type
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