Treatment of central retinal vein occlusion-related macular edema with intravitreal bevacizumab (Avastin): preliminary results.

Abstract:

PURPOSE:To assess the safety and efficacy of treatment of macular edema secondary to central retinal vein occlusion (CRVO) with intravitreal bevacizumab. PATIENTS AND METHOD:The ongoing prospective study included 8 consecutive patients (8 eyes) with macular edema secondary to CRVO (6 non ischemic and 2 ischemic), treated with intravitreal injection of 1.25 mg (0.05 mL) of bevacizumab. Main outcome was best corrected visual acuity (BCVA) and central foveal thickness (CFT) measured by optical coherence tomography monthly during one year. Retreatment criteria include decrease of BCVA, persistence of macular edema on angiograms and increase of CFT. RESULTS:Mean age of the eight patients was 68 years (range: 50-82 years). Mean duration of symptoms before injection was 98 days (range: 3-289). Mean follow-up was 3.25 months. At baseline, mean BCVA was 0.84 logMar and mean baseline CFT was 771 microm. Mean BCVA was 0.36 and mean CFT thickness was 275 microm (n = 8) at month 1, 0.41 and 411 microm at month 2 (n = 7), 0.3 and 344 microm at month 3 (n = 6), 0.3 and 397 microm at month 4 (n = 5), respectively. In 75 % of patients, a single injection was not sufficient, and retreatment needed. No serious adverse events were observed. CONCLUSIONS:Treatment of macular edema secondary to CRVO with intravitreal bevacizumab injection of 1.25 mg was well tolerated and associated with marked macular thickness reduction and BCVA improvement in all patients. A trend towards reduction of foveal thickness and improvement of visual acuity was observed in both acute and chronic CRVO.

journal_name

Klin Monbl Augenheilkd

authors

Pournaras JA,Nguyen C,Vaudaux JD,Konstantinidis L,Ambresin A,Wolfensberger T

doi

10.1055/s-2008-1027258

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

397-400

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

225

pub_type

临床试验,杂志文章
  • [A convex-concave contact lens for vitreoretinal operations with the BIOM].

    abstract::A new convex-concave contact lens for wide-angle vitreoretinal surgery with the BIOM was developed. Placed on an eye, in which silicone oil is injected, it prevents the formation of an optically disturbing oil-water-film on the surface of the cornea. Thus the new contact lens leads to an essential improvement of the f...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045932

    authors: Eckardt C,Wiechens B

    更新日期:1991-01-01 00:00:00

  • [Medical Management of Glaucoma].

    abstract::Glaucoma is the leading cause of irreversible blindness in Germany and in the world. Due to the multifactorial genesis of the disease, there are multiple therapeutic approaches for preventing its progression. The goal of the commonly used topical glaucoma medication is to reduce the intraocular pressure and therefore ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-1229-1390

    authors: Emrani E

    更新日期:2020-10-01 00:00:00

  • [A new type of eye speculum (author's transl)].

    abstract::A new type of eye speculum is described. It has the following advantages: it does not hamper the surgeon in his work, it has no projecting parts on which sutures may get caught, and it enables spreading of the eyelids to be controlled. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Oosterhuis JA,Fakkel J

    更新日期:1975-06-01 00:00:00

  • [Echographic findings in choroidal detachment].

    abstract::A- and B-scan sonography was performed in 83 patients with choroidal detachment; a serous choroidal detachment is characterized by high, bifurcated echospikes and an echo-free subchoroidal space in A-scan sonography. The B-scan presents a typical arc shape. In hemorrhagic choroidal detachment multiple echoes with low ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054708

    authors: Rochels R,Hackelbusch R

    更新日期:1983-01-01 00:00:00

  • [Clinical value of scanning laser polarimetry in glaucoma diagnostics].

    abstract::The term glaucoma is used as a melting pot of many different diseases which have in common that the retinal ganglion cells and their axons are damaged. Untreated, apoptosis can be induced causing ganglion cell death which subsequently leads to typical glaucomatous damage at the optic nerve head, scotomas of the visual...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1299246

    authors: Kremmer S,Anastassiou G,Selbach JM

    更新日期:2012-02-01 00:00:00

  • Comparing Short-Duration Electro-Oculograms with and without Mydriasis in Healthy Subjects.

    abstract:BACKGROUND:In order to obtain artifact-free electro-oculogram recordings the subject's cooperation is necessary. The aim of our study is to evaluate the recording characteristics of short-duration EOG and to compare the effect of mydriasis on electro-oculogram recordings in a cohort of controls. PATIENTS AND METHODS:E...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,随机对照试验

    doi:10.1055/s-0034-1396330

    authors: Türksever C,Orgül S,Todorova MG

    更新日期:2015-04-01 00:00:00

  • [Eyelid tumor as a recurrence of a gastric MALT-lymphoma].

    abstract:BACKGROUND:MALT Lymphoma of the conjunctiva, eyelid and orbit represents a primary manifestation of the disease in most of the cases. CASE REPORT:A 58-year-old male presented with a tumor in the left inferior eyelid. A full-thickness incisional biopsy was performed. Histopathologically, a lymphoid infiltrate involved ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2000-10398

    authors: Colombo F,Viestenz A,Holbach LM

    更新日期:2000-08-01 00:00:00

  • [Laser scanning topography and polarimetry with implantation of intraocular lenses before and after cataract surgery].

    abstract:BACKGROUND:In the last years, scanning laser measurements were established in glaucoma diagnostics. Techniques of special interest are scanning laser topometry (SLT) for exact measurements of the optic disc and its cup and scanning laser polarimetry (SLP) for precise assessment of the retinal nerve fiber layer thicknes...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034816

    authors: Kremmer S,Pflug A,Heiligenhaus A,Fanihagh F,Steuhl KP

    更新日期:1999-06-01 00:00:00

  • [Haemoglobin oxygenation of retinal vessels in branch retinal artery occlusions over time and correlation with clinical outcome].

    abstract:OBJECTIVE:Purpose of these study was the evaluation of a new method for the measurement of haemoglobin oxygenation in retinal vessels. Patients with branch retinal artery occlusion have been measured before and after a rheological therapy. METHODS:The haemoglobin oxygenation in retinal vessels was measured by the "oxy...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0029-1245117

    authors: Gehlert S,Dawczynski J,Hammer M,Strobel J

    更新日期:2010-12-01 00:00:00

  • [Measurement of the diameter of segments of retinal branch vessels in digital fundus images - An experimental study of the method and reproducibility].

    abstract:PURPOSE:The aim of this study was the evaluation of new algorithms to measure diameter of segments of retinal branch vessels offline in local dependence and independent by observer. Methods 360 flashed fundus images (camera FF 450 ZEISS Germany, Visualis IMEDOS GmbH Weimar/Germany) of 12 eyes of healthy volunteers (10 ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2001-17640

    authors: Nagel E,Münch K,Vilser W

    更新日期:2001-09-01 00:00:00

  • [Myelinization of the optic nerve in the albino mouse (the Agnes Bluhm Jena-Halle strain)].

    abstract::Knowledge of normal differentiations is indispensable for interpreting developmental disturbances in animal experiments. Accordingly, the investigations described in the present paper were aimed at explaining the process of myelinization of the optic nerve in the domestic mouse breed Agnes Bluhm Jena-Halle. First sign...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054917

    authors: Bernstein E,Tost M,Holzhausen HJ

    更新日期:1983-10-01 00:00:00

  • [High altitude retinal hemorrhages in mountain climbers (author's transl)].

    abstract::A report is given on three patients who noticed an acute deterioration of visual acuity after a sojourn at 5000 altitude caused by retinal hemorrhages. We documented both the ophthalmological examinations such as visual acuity, fundus, perimetry and fluorescence-angiography and the systemic results. During the period ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Vogt C,Greite JH,Hess J

    更新日期:1978-05-01 00:00:00

  • [Useful examinations and therapies in immunologic diseases].

    abstract::Screening by immune disease is useful for one part in the various ocular inflammatory processes, uveitis, vasculitis, (epi)scleritis and myositis, for the other in collagen diseases with possible eye complications. The various forms of uveitis can be related either to rheumatic disease, to some HLA antigen, to a micro...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1045632

    authors: Martenet AC

    更新日期:1993-05-01 00:00:00

  • [Use of a new anomaloscope test in diagnosis of glaucoma].

    abstract:BACKGROUND:The Color Vision Meter 712 (CVM) is a new automatic computerized anomaloscope relying on both the Rayleigh and the Moreland equation. In the present study the diagnostic value of Color Vision Meter was examined in glaucoma for the first time and was compared with the Farnsworth 100 hue test. PATIENTS AND ME...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035512

    authors: Nguyen NX,Korth M,Wisse M,Jünemann A

    更新日期:1994-03-01 00:00:00

  • [Effect of rubeosis iridis and active neovascularization of the fundus on vitreous surgery in diabetic retinopathy].

    abstract::To determine the influence of preoperative rubeosis iridis and active neovascularization at the fundus on surgical results, the authors analyzed a consecutive series of 85 eyes that underwent vitrectomy for diabetic tractional detachment of the macula. Minimum follow-up was 12 months. Rubeosis was present in 51%, acti...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050199

    authors: Oldendoerp J,Spitznas M

    更新日期:1988-06-01 00:00:00

  • Reattachment of Descemet's membrane using C3F8 gas in an eye with a Baerveldt aqueous shunt.

    abstract::Descemetʼs membrane detachment (DMD) is a rare complication following cataract and glaucoma surgery as well as lamellar graft procedures. DMD can lead to blurry vision, halos and severe visual loss. Clinically, when there is a large central detachment, a double anterior chamber is seen to form. In this scenario, surgi...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328333

    authors: Wimmersberger Y,Bergin C,Sharkawi E

    更新日期:2013-04-01 00:00:00

  • [The abortion problem from the ophthalmologist's point of view (author's transl)].

    abstract::This article is devoted to the problems associated with termination of pregnancy as seen by the ophthalmologist. It starts by pointing out the ophthalmological indications which have to be considered in this connection. Pediatric indications are then discussed, in particular the highly problematic clinical picture of ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057191

    authors: Mewe L

    更新日期:1981-03-01 00:00:00

  • [Long-term treatment of circulatory disturbances of the retina and optic (author's transl)].

    abstract::Forty-six patients with in most cases severe vascular degenerative retinochoroidal circulatory disturbances or with glaucomatous visual field defects were treated with rökan dragées (160 mg/day for four weeks, then 120 mg/day). The following were checked at monthly intervals to determine the degree of success of the t...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Merté HJ,Merkle W

    更新日期:1980-11-01 00:00:00

  • [The learning curve in refractive laser surgery: criteria for outcome evaluation].

    abstract:BACKGROUND:We wanted to analyse and compare the results of our first 100 cases of refractive surgery using the commonly accepted refractive parameters and using more subjective data. MATERIALS AND METHODS:Retrospective analysis of the first 100 consecutive cases of refractive surgery using objective and subjective cri...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Artaria LG

    更新日期:1998-05-01 00:00:00

  • Treating Fungal Keratitis with Oral Voriconazole Only: A Case Series.

    abstract:BACKGROUND:To report the clinical effect of oral voriconazole only as a treatment for fungal keratitis. HISTORY AND SIGNS:Three patients (1 female and 2 males) with culture-proven fungal keratitis (1 Mucoraceae, 1 Aspergillus, 1 Fusarium) were included in this study. The patients were treated with oral voriconazole 20...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-1268-9168

    authors: Chen D,Tan S,Zou W

    更新日期:2021-01-01 00:00:00

  • [Eyelid Tumors: Clinical Aspects of Ophthalmic Pathology].

    abstract:BACKGROUND:Lid tumors show a heterogenous clinical spectrum. Tumors which display some criteria of malignancy may histologically be diagnosed as inflammatory lesions without any neoplastic component. In contrast, malignant tumors can induce changes on the lid margin mimicking inflammatory changes. MATERIAL AND METHODS...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/a-0633-3120

    authors: Herwig-Carl MC,Löffler KU

    更新日期:2018-07-01 00:00:00

  • [Prognosis in repeat keratoplasty: per indication analysis in a large monocentric cohort].

    abstract:BACKGROUND:Data from national graft registries suggests a limited prognosis in the group of all repeat keratoplasties. This group might rather consist mostly of cases already classified as high risk in the first place, however. Thus, repeat keratoplasties in normal risk indications might have a substantially better pro...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027127

    authors: Böhringer D,Reinhard T

    更新日期:2008-01-01 00:00:00

  • [Complications after lid loading. Is the platinum chain really effective?].

    abstract:INTRODUCTION:Numerous studies on the operative therapy for lagophthalmos exist. Reports about postoperative results, however, are rare and most studies include just a small number of patients. Additionally, since 1999a flexible platinum chains has been available as an alternative to the rigid gold implant. The authors ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-963790

    authors: Schrom T,Loch A,Habermann A,Knipping S

    更新日期:2008-02-01 00:00:00

  • [Nyktometric examinations on eye function in diabetic retinopathy (author's transl)].

    abstract::By means of nyctometry we examinated in a group of normal persons and in a group of juvenile diabetics if the adaptability of the adaptation system in possible under various conditions of initial adaptation. It appears, that nondiabetics possess a sufficiently reactive functional system, while in diabetics, we found a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Schulze DP,Freese R,Sauerwald R

    更新日期:1976-09-01 00:00:00

  • [Necessary pressure in the ophthalmic artery].

    abstract::As a result of an acute pathologic event ophthalmic arterial pressure may fall below a level necessary to supply sufficient blood to the eye and optic nerve, and thus to preserve full visual function. A sudden partial or even total loss of visual function. A sudden partial or even total loss of vision may follow. In s...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057432

    authors: Stepanik J

    更新日期:1980-02-01 00:00:00

  • [Lymphatic congestion of the conjunctiva after pre-auricular lymph node excision].

    abstract:PATIENT:A 68-year-old woman presented with massive congestion of lymphatic vessels of temporal inferior conjunctiva two months after extirpation of the parotic gland for an aciniform epithelioma on the same side. Clinical findings of the right and left eye were unremarkable otherwise. The congestion resolved spontaneou...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035351

    authors: Gugutschkova P,Angelov B

    更新日期:1995-07-01 00:00:00

  • [The Motor Development of Children with Infantile Esotropia].

    abstract::Background Until now, many studies have investigated the link between motor development and visual-spatial abilities in infancy and childhood. Most of these studies found evidence that there is such a link in typically developing children or children with locomotor delay. Only a few studies have tested the consequence...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-118831

    authors: Dillmann J,Freitag C,Holve K,Schweinfurth S,Lorenz B,Schwarzer G

    更新日期:2017-10-01 00:00:00

  • [Sensitivity of the computer perimeter Competer in early glaucomatous loss of visual field. A controlled study].

    abstract::Comparative examinations were carried out under controlled conditions in 101 eyes of 66 open-angle glaucoma patients with field defects (Stages I-III according to Aulhorn) with the Octopus and Competer computerized perimeters. The results of the Octopus perimetry were selected as a reference system to evaluate the sen...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055050

    authors: Gramer E,Gerlach R,Krieglstein GK

    更新日期:1982-03-01 00:00:00

  • [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database].

    abstract:BACKGROUND:Uveitis is a frequent and potentially vision-threatening manifestation of juvenile idiopathic arthritis (JIA). There are only a few population-based studies providing data on the frequency and severity of uveitis. METHODS:Documentation of patients with JIA was collected in a national database. An analysis o...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2005-858753

    authors: Heiligenhaus A,Niewerth M,Mingels A,Ganser G,Thon A,Pleyer U,Greiner K,Minden K

    更新日期:2005-12-01 00:00:00

  • [Malignant teratoid medulloepithelioma of the ciliary body and glial fibrillary acidic protein. Clinical, histochemical and immunohistochemical findings].

    abstract::In a four-year-old boy a malignant teratoid medulloepithelioma of the ciliary body was removed by means of an 11.0 X 11.0 mm "block excision". Two years later the patients visual acuity was 0.6. The lesion originates in the nonpigmented ciliary epithelium, extending along the lens equator to the pupillary zone and thr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1051036

    authors: Holbach L,Völcker HE,Naumann GO

    更新日期:1985-10-01 00:00:00