Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.

abstract：:Polyclonal B cell activation is not a peculiar characteristic to a particular infection, as many viruses, bacteria, and parasites induce a strong polyclonal B cell response resulting in hyper-gamma-globulinemia. Here, we discuss the different roles proposed for polyclonal B cell activation, which can be crucial for ea...

journal_title：Journal of leukocyte biology

authors： Montes CL,Acosta-Rodríguez EV,Merino MC,Bermejo DA,Gruppi A

更新日期：2007-11-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Adherence of monocytes to extracellular matrix components is critical for their accumulation at sites of infection. To gain insight into the factors that regulate monocyte recruitment, we have studied monocyte adherence with regard to the regulatory effects of bacterial lipopolysaccharide (LPS) and the mechanisms invo...

journal_title：Journal of leukocyte biology

authors： Owen CA,Campbell EJ,Stockley RA

更新日期：1992-04-01 00:00:00

abstract：:Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in Parkinson's disease (PD). Emerging evidence supports the notion that microglia neuroinflammatory responses speed neurodegenerative events. We demonstrated previously tha...

journal_title：Journal of leukocyte biology

authors： Reynolds AD,Banerjee R,Liu J,Gendelman HE,Mosley RL

更新日期：2007-11-01 00:00:00

abstract：:Neutrophil activation is a multistep process. In vitro activation of neutrophils with semiphysiological activators is optimal only after preactivation or priming with cytokines, chemotaxins, and/or bacterial products. Until now, no antibodies have been developed that can distinguish between resting and (cytokine) prim...

journal_title：Journal of leukocyte biology

authors： Koenderman L,Kanters D,Maesen B,Raaijmakers J,Lammers JW,de Kruif J,Logtenberg T

更新日期：2000-07-01 00:00:00

abstract：:The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

journal_title：Journal of leukocyte biology

authors： Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

更新日期：2015-04-01 00:00:00

abstract：:During the neoplastic progression, macrophages as well as dendritic and NK cells are attracted into the tumor site and initiate the immune response against transformed cells. They activate and present tumor antigens to T cells, which are then activated to kill tumor cells. However, tumor cells are often capable of esc...

journal_title：Journal of leukocyte biology

authors： Lamagna C,Aurrand-Lions M,Imhof BA

更新日期：2006-10-01 00:00:00

abstract：:Although all the cells in an organism contain the same genetic information, differences in the cell phenotype arise from the expression of lineage-specific genes. During myelopoiesis, external differentiating signals regulate the expression of a set of transcription factors. The combined action of these transcription ...

journal_title：Journal of leukocyte biology

authors： Valledor AF,Borràs FE,Cullell-Young M,Celada A

更新日期：1998-04-01 00:00:00

abstract：:Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex cla...

journal_title：Journal of leukocyte biology

authors： Setterblad N,Blancheteau V,Delaguillaumie A,Michel F,Bécart S,Lombardi G,Acuto O,Charron D,Mooney N

更新日期：2004-06-01 00:00:00

abstract：:Rac2 is a hematopoietic-specific Rho-GTPase that plays a stimulus-specific role in regulating reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and other functional responses in neutrophils. In this study, rac2-/- neutrophils were shown to have significantly decreased NADPH oxidase activit...

journal_title：Journal of leukocyte biology

authors： Kim C,Dinauer MC

更新日期：2006-01-01 00:00:00

abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

journal_title：Journal of leukocyte biology

authors： Dunne AL,Siregar H,Mills J,Crowe SM

更新日期：1994-09-01 00:00:00

abstract：:Nitric oxide (NO(.-)) contributes to vascular collapse in septic shock and regulates inflammation. Here, we demonstrate in lipopolysaccharide (LPS)-stimulated human THP-1 cells and monocytes that NO(.-) regulates interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha) by distinct mechanisms. Dibutyryl-cyclic gu...

journal_title：Journal of leukocyte biology

authors： Ma P,Cui X,Wang S,Zhang J,Nishanian EV,Wang W,Wesley RA,Danner RL

更新日期：2004-07-01 00:00:00

abstract：:There is growing evidence that, in addition to their role as initiators of immune responses, dendritic cells (DC) can exhibit tolerogenic properties. Immature DC deficient in cell surface costimulatory/accessory molecules can prolong organ and pancreatic islet allograft survival, whereas in vitro manipulation of DC by...

journal_title：Journal of leukocyte biology

authors： Lu L,Lee WC,Takayama T,Qian S,Gambotto A,Robbins PD,Thomson AW

更新日期：1999-08-01 00:00:00

abstract：:Eosinophils are traditionally associated with allergic and parasitic inflammation. More recently, eosinophils have also been shown to have roles in diverse processes including development, intestinal health, thymic selection, and B-cell survival with the majority of these insights being derived from murine models and ...

journal_title：Journal of leukocyte biology

authors： Nguyen WNT,Jacobsen EA,Finney CAM,Colarusso P,Patel KD

更新日期：2020-07-01 00:00:00

abstract：:TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane o...

journal_title：Journal of leukocyte biology

authors： Marongiu L,Gornati L,Artuso I,Zanoni I,Granucci F

更新日期：2019-07-01 00:00:00

abstract：:DCs orchestrate immune responses contributing to the pattern of response developed. In cancer, DCs may play a dysfunctional role in the induction of CD4(+)CD25(+)Foxp3(+) Tregs, contributing to immune evasion. We show here that Mo-DCs from breast cancer patients show an altered phenotype and induce preferentially Treg...

journal_title：Journal of leukocyte biology

authors： Ramos RN,Chin LS,Dos Santos AP,Bergami-Santos PC,Laginha F,Barbuto JA

更新日期：2012-09-01 00:00:00

abstract：:T cell Ig and mucin domain-containing molecule 3 (Tim-3) has been found to play important roles in autoimmune diseases, but whether Tim-3-mediated engulfment of apoptotic cells is involved in systemic lupus erythematosus (SLE) remains to be elucidated. In this study, we verified the role of human Tim-3 (hTim-3) as the...

journal_title：Journal of leukocyte biology

authors： Zhao D,Guo M,Liu B,Lin Q,Xie T,Zhang Q,Jia X,Shu Q,Liang X,Gao L,Ma C

更新日期：2017-12-01 00:00:00

abstract：:Endotoxin tolerance is characterized by diminished expression of inflammatory cytokines after sequential exposure to Toll-like receptor stimuli. Many mechanisms contribute to tolerance; however, chromatin remodeling appears to be the most significant regulator. The type II interferon, IFN-γ, has been recognized as bei...

journal_title：Journal of leukocyte biology

authors： Shi L,Song L,Maurer K,Sharp J,Zhang Z,Sullivan KE

更新日期：2015-10-01 00:00:00

abstract：:Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for ...

journal_title：Journal of leukocyte biology

authors： Ode Y,Aziz M,Wang P

更新日期：2018-04-01 00:00:00

abstract：:Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically ...

journal_title：Journal of leukocyte biology

authors： Pagès F,Galon J,Fridman WH

更新日期：2008-10-01 00:00:00

abstract：:Macrophages play major roles in the onset of immune responses and inflammation by inducing a variety of cytokines such as TNF and IFN-beta. The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used to study type-I IFN and TNF responses in human macrophages. Additionally,...

journal_title：Journal of leukocyte biology

authors： Reimer T,Brcic M,Schweizer M,Jungi TW

更新日期：2008-05-01 00:00:00

abstract：:Antibody-facilitated macrophage (MP) destruction of Trypanosoma musculi involves ingestion and intracellular degradation of the parasites. It is likely, however, as we show here, that death of the trypanosomes is extracellular and it is the corpses that are ingested by MPs. We have utilized both peritoneal MPs and a c...

journal_title：Journal of leukocyte biology

authors： Albright JW,Stewart MJ,Latham PS,Albright JF

更新日期：1994-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS) has been shown to induce proliferation of human T-lymphocytes only in the presence of monocytes and CD34(+) hematopoietic cells (HCs) from peripheral blood. This finding provided evidence of an active role of CD34(+) HCs during inflammation and immunological events. To investigate mechanisms b...

journal_title：Journal of leukocyte biology

authors： Umland O,Heine H,Miehe M,Marienfeld K,Staubach KH,Ulmer AJ

更新日期：2004-04-01 00:00:00

abstract：:Neutrophil's responses to G protein-coupled chemoattractants are highly dependent on store-operated calcium (Ca(2+)) entry (SOCE). Platelet-activating factor (PAF), a primary chemoattractant, simultaneously increases cytosolic-free Ca(2+), intracellular pH (pH(i)), ERK1/2, and Akt/protein kinase B (PKB) phosphorylatio...

journal_title：Journal of leukocyte biology

authors： Sandoval AJ,Riquelme JP,Carretta MD,Hancke JL,Hidalgo MA,Burgos RA

更新日期：2007-11-01 00:00:00

abstract：:Secretory leukocyte proteinase inhibitor (SLPI) is the main neutrophil elastase (HLE) inhibitor found in the upper airways during pulmonary inflammation. It has been shown to be synthesized and secreted in vitro by epithelial cells and has been localized in tracheal glands and bronchiolar epithelial cells by immunocyt...

journal_title：Journal of leukocyte biology

authors： Sallenave JM,Si Tahar M,Cox G,Chignard M,Gauldie J

更新日期：1997-06-01 00:00:00

abstract：:Initial studies designed to measure the effect of inhibiting RNA synthesis by dactinomycin on macrophage functions revealed that the cells were uniformly killed at concentrations that have been routinely used to inhibit RNA synthesis in other cell types. We, thus, determined the dose curve for the cytotoxicity of dact...

journal_title：Journal of leukocyte biology

authors： Lewis JG,Adams DO,Fan S

更新日期：1995-04-01 00:00:00

abstract：:Murine peritoneal exudate cells (PEC) pre-exposed to bacterial lipopolysaccharide (LPS) show augmented nitric oxide (NO) production by LPS restimulation, in contrast to LPS tolerance with reduced production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Significant amounts of interferon-gamma (IF...

journal_title：Journal of leukocyte biology

authors： Tominaga K,Saito S,Matsuura M,Funatogawa K,Matsumura H,Nakano M

更新日期：1999-12-01 00:00:00

abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

journal_title：Journal of leukocyte biology

authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

更新日期：2012-04-01 00:00:00

abstract：:Discussion on targeting LXR and PPAR agonists as therapeutic alternatives to ustekinumab therapy in LAD-1. ...

journal_title：Journal of leukocyte biology

authors： Cooper KN,Bagaitkar J

更新日期：2020-11-01 00:00:00