Technical note: the calibration of 90Y-labeled SIR-Spheres using a nondestructive spectroscopic assay.

Abstract:

:90Y-labeled SIR-Spheres are currently used to treat patients with hepatic metastases secondary to colorectal adenocarcinoma. In general, the prescribed activity is based on empirical data collected during clinical trials. The activity of the source vial is labeled by the manufacturer as 3.0 GBq +/- 10% and is not independently verified by the end user. This technical note shows that the results of a nondestructive spectroscopic assay of a SIR-Spheres sample was 26% higher than the activity stated by the manufacturer. This difference should not impact the current empirical prescription method but may be problematic for patient-specific dosimetry applications, such as image-based dosimetry.

journal_name

Med Phys

journal_title

Medical physics

authors

Selwyn R,Micka J,DeWerd L,Nickles R,Thomadsen B

doi

10.1118/1.2889621

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

1278-9

issue

4

eissn

0094-2405

issn

2473-4209

journal_volume

35

pub_type

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