Abstract:
:Recombinant activated factor VII (rFVIIa) is being increasingly used to treat bleeding associated with a variety of non-hemophilic coagulopathic indications, and its mechanism of action in these areas is under active investigation. Numerous studies have shown that FVIIa binds with low affinity to activated platelets; rFVIIa can subsequently enhance platelet-surface thrombin generation by activating factor (F) X and by contributing additional FIXa to the hemostatic process. This FIXa can rapidly activate additional FX, which may explain why non-hemophilic coagulopathic bleeds respond to lower doses of rFVIIa than do hemophilic bleeds. However, the platelet surface may be able to process only a limited amount of FXa, accounting for the observation that some models of non-hemophilic coagulopathy show a plateau in the effect of rFVIIa.
journal_name
Semin Hematoljournal_title
Seminars in hematologyauthors
Monroe DMdoi
10.1053/j.seminhematol.2008.03.013subject
Has Abstractpub_date
2008-04-01 00:00:00pages
S7-S11issue
2 Suppl 1eissn
0037-1963issn
1532-8686pii
S0037-1963(08)00053-Xjournal_volume
45pub_type
杂志文章,评审abstract::Continuous daily treatment with all-trans-retinoic acid (ATRA) in patients with acute promyelocytic leukemia has been associated with a marked decline in the plasma drug concentration at the time of relapse. Recent pharmacologic studies have attempted to determine the reasons for the progressive reduction of plasma co...
journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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更新日期:1997-07-01 00:00:00
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
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更新日期:1998-04-01 00:00:00
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
pub_type: 历史文章,杂志文章,评审
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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