Abstract:
:Products of the Stannius corpuscles (SC) of rainbow trout were tested in an established PTH bioassay involving bone resorption in embryonic mouse calvaria. Aqueous extracts from Stannius corpuscles (SC-homogenate) showed a bone-resorbing activity comparable to PTH in 24-h cultures of calvaria, indicated by a dose-dependent stimulation of lactate production and of calcium, phosphate as well as beta-glucuronidase release. Moreover, SC-homogenates induced an increase in osteoclastic activity. The PTH-like SC-principle is released during in vitro incubations of the glands. These results and the lack of an additive effect of SC-products and PTH on bone resorption suggest that both products activate the same receptor. We hypothesize that the hypocalcemic hormone of the SC of fish shares structural resemblance with PTH, the major hypercalcemic hormone of terrestrial vertebrates.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Lafeber FP,Schaefer HI,Herrmann-Erlee MP,Wendelaar Bonga SEdoi
10.1210/endo-119-5-2249subject
Has Abstractpub_date
1986-11-01 00:00:00pages
2249-55issue
5eissn
0013-7227issn
1945-7170journal_volume
119pub_type
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