Inhibition of tumor angiogenesis by tumstatin: insights into signaling mechanisms and implications in cancer regression.

Abstract:

:Growing tumors develop additional new blood vessels to meet the demand for adequate nutrients and oxygen, a process called angiogenesis. Cancer is a highly complex disease promoted by excess angiogenesis; interfering with this process poses for an attractive approach for controlling tumor growth. This hypothesis led to the identification of endogenous angiogenesis inhibitors generated from type IV collagen, a major component of vascular basement membrane (VBM). Type IV collagen and the angiogenesis inhibitors derived from it are involved in complex roles, than just the molecular construction of basement membranes. Protease degradation of collagens in VBM occurs in various physiological and pathological conditions and produces several peptides. Some of these peptides are occupied in the regulation of functions conflicting from those of their original integral molecules. Tumstatin (alpha3(IV)NC1), a proteolytic C-terminal non-collagenous (NC1) domain from type IV collagen alpha3 chain has been highlighted recently because of its potential role in anti-angiogenesis, however its biological actions are not limited to these processes. alpha3(IV)NC1 inhibits proliferation by promoting endothelial cell apoptosis and suppresses diverse tumor angiogenesis, thus making it a potential candidate for future cancer therapy. The present review surveys the physiological functions of type IV collagen and discovery of alpha3(IV)NC1 as an antiangiogenic protein with a comprehensive overview of the knowledge gained by us towards understanding its signaling mechanisms.

journal_name

Pharm Res

journal_title

Pharmaceutical research

authors

Sudhakar A,Boosani CS

doi

10.1007/s11095-008-9634-z

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

2731-9

issue

12

eissn

0724-8741

issn

1573-904X

journal_volume

25

pub_type

杂志文章,评审
  • Transepithelial transport of insulin: I. Insulin degradation by insulin-degrading enzyme in small intestinal epithelium.

    abstract:PURPOSE:The purpose of this study was to determine the existence of insulin-degrading enzyme (EC 3.4.22.11) (IDE) in rat intestinal enterocytes. METHODS:Subcellular fractionation, biochemical characterization, immunoprecipitation, and western blots were employed. RESULTS:Insulin-degrading activity was localized in th...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1016263926946

    authors: Bai JP,Chang LL

    更新日期:1995-08-01 00:00:00

  • Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy.

    abstract::A novel application of attenuated total reflectance IR spectroscopy (ATR-IR) was used to monitor the outer several microns of the stratum corneum (SC) and, thereby, demonstrate enhanced percutaneous absorption in vivo in man. 4-Cyanophenol (CP) as a model permeant yielded a unique IR signal, distinct from those of the...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1015960815578

    authors: Mak VH,Potts RO,Guy RH

    更新日期:1990-08-01 00:00:00

  • The Influence of Stabilized Deconjugated Ursodeoxycholic Acid on Polymer-Hydrogel System of Transplantable NIT-1 Cells.

    abstract:PURPOSE:The encapsulation of pancreatic β-cells in biocompatible matrix has generated great interest in diabetes treatment. Our work has shown improved microcapsules when incorporating the bile acid ursodeoxycholic acid (UDCA), in terms of morphology and cell viability although cell survival remained low. Thus, the stu...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-016-1863-y

    authors: Mooranian A,Negrulj R,Al-Salami H

    更新日期:2016-05-01 00:00:00

  • Metabolism of diltiazem in hepatic and extrahepatic tissues of rabbits: in vitro studies.

    abstract::Diltiazem (DTZ) is a calcium channel blocker widely used in the treatment of angina and hypertension. DTZ undergoes extensive metabolism yielding several metabolites, some of which are active like N-desmethyldiltiazem (MA), desacetyldiltiazem (M1) and N-desmethyl,desacetyldiltiazem (M2). Due to the nature of its biotr...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1016226601988

    authors: Homsy W,Lefebvre M,Caillé G,du Souich P

    更新日期:1995-04-01 00:00:00

  • Structure-activity relationships for substrates and inhibitors of mammalian liver microsomal carboxylesterases.

    abstract:PURPOSE:Carboxylesterases are important in the detoxification of drugs, pesticides and other xenobiotics. This study was to evaluate a series of substrates and inhibitors for characterizing these enzymes. METHODS:A series of novel aliphatic esters and thioesters were used in spectral assays to monitor human, murine an...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1016071311190

    authors: Huang TL,Shiotsuki T,Uematsu T,Borhan B,Li QX,Hammock BD

    更新日期:1996-10-01 00:00:00

  • Dissolution testing of hardly soluble materials by surface sensitive techniques: clotrimazole from an insoluble matrix.

    abstract:PURPOSE:The low aqueous solubility of many drugs impedes detailed investigation as the detection limit of standard testing routines is limited. This is further complicated within application relevant thin films typical used in patches or stripes for buccal or topical routes. METHODS:In this work a model system is deve...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-014-1368-5

    authors: Ehmann HM,Winter S,Griesser T,Keimel R,Schrank S,Zimmer A,Werzer O

    更新日期:2014-10-01 00:00:00

  • Evaluation of renal tubular secretion and reabsorption of levofloxacin in rats.

    abstract:PURPOSE:Levofloxacin, a quinolone antibacterial drug, is a zwitterion at physiological pH. We examined the effect of cationic and anionic drugs on renal excretion of levofloxacin by means of in vivo clearance to characterize the mechanisms of renal excretion of this drug. METHODS:In vivo clearance was studied in male ...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1012111902798

    authors: Yano I,Ito T,Takano M,Inui K

    更新日期:1997-04-01 00:00:00

  • Bioactive-Chylomicrons for Oral Lymphatic Targeting of Berberine Chloride: Novel Flow-Blockage Assay in Tissue-Based and Caco-2 Cell Line Models.

    abstract:PURPOSE:To develop novel bioactive-chylomicrons to solve oral delivery obstacles of Berberine chloride and target the lymphatic system. METHODS:Berberine-loaded bioactive-chylomicrons were prepared and underwent full in vitro characterization. Intestinal permeability was appraised via both non-everted gut sac model an...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-017-2307-z

    authors: Elsheikh MA,Elnaggar YSR,Otify DY,Abdallah OY

    更新日期:2018-01-05 00:00:00

  • Use of in vivo animal models to assess pharmacokinetic drug-drug interactions.

    abstract::Animal models are used commonly in various stages of drug discovery and development to aid in the prospective assessment of drug-drug interaction (DDI) potential and the understanding of the underlying mechanism for DDI of a drug candidate. In vivo assessments in an appropriate animal model can be very valuable, when ...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章,评审

    doi:10.1007/s11095-010-0157-z

    authors: Tang C,Prueksaritanont T

    更新日期:2010-09-01 00:00:00

  • lontophoretic Devices for Drug Delivery.

    abstract::Transdermal drug delivery of ionized drugs can be enhanced by iontophoresis. Drug in the ionic form, contained in some reservoir, can be "phoresed" through the skin with a small current across two electrodes, one above the reservoir and one at a distal skin location. Positive ions can be introduced from the positive p...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/A:1016327822325

    authors: Tyle P

    更新日期:1986-12-01 00:00:00

  • Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

    abstract:PURPOSE:The aim of this study is to investigate the effects of 50% ethyl acetate extracts of grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) in the rat small intestine. METHODS:The efflux of P-gp substrates from rat everted sac in the absence or presence of verapamil, GF...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1016100715125

    authors: Tian R,Koyabu N,Takanaga H,Matsuo H,Ohtani H,Sawada Y

    更新日期:2002-06-01 00:00:00

  • Amplification of butyrylcholinesterase and acetylcholinesterase genes in normal and tumor tissues: putative relationship to organophosphorous poisoning.

    abstract::Cholinesterases are ubiquitous carboxylesterase type B enzymes capable of hydrolyzing the neurotransmitter acetylcholine which are transiently expressed in multiple germline, embryonic, and tumor cells. The acute poisoning effects of various organophosphorous compounds are generally attributed to their irreversible co...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015867021628

    authors: Soreq H,Zakut H

    更新日期:1990-01-01 00:00:00

  • Effects of excipients on the hydrogen peroxide-induced oxidation of methionine residues in granulocyte colony-stimulating factor.

    abstract:PURPOSE:The objective of this study was to elucidate the different mechanisms of action of different excipients on the oxidation of Met1, Met122, Met127, and Met138 in granulocyte colony-stimulating factor (G-CSF) by using hydrogen peroxide as the oxidant. METHODS:The oxidation of Met1, Met127, and Met138 was quantifi...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-004-9019-x

    authors: Yin J,Chu JW,Ricci MS,Brems DN,Wang DI,Trout BL

    更新日期:2005-01-01 00:00:00

  • Blood-brain barrier transport of 125I-labeled basic fibroblast growth factor.

    abstract:PURPOSE:This study was carried out to examine the blood-brain barrier (BBB) transport of human basic fibroblast growth factor (bFGF) and investigate its mechanism. METHODS:The BBB transport of 125I-bFGF was measured by several in vivo methods including intravenous administration, in situ internal carotid artery perfus...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1007570509232

    authors: Deguchi Y,Naito T,Yuge T,Furukawa A,Yamada S,Pardridge WM,Kimura R

    更新日期:2000-01-01 00:00:00

  • Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR.

    abstract:PURPOSE:Effects of polyvinylpyrrolidone (PVP) molecular weight on the solid-state intermolecular interactions among probucol/PVP/sodium dodecyl sulfate (SDS) ternary ground mixtures (GM) and the formation of nanoparticles were investigated by solid-state NMR spectroscopy. MATERIALS AND METHODS:Ternary GMs of probucol ...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-006-9089-z

    authors: Pongpeerapat A,Higashi K,Tozuka Y,Moribe K,Yamamoto K

    更新日期:2006-11-01 00:00:00

  • Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization.

    abstract:PURPOSE:The gadopentetic acid (Gd-DTPA)-loaded chitosan nanoparticles (Gd-nanoCPs) were prepared for gadolinium neutron-capture therapy (Gd-NCT) and characterized and evaluated as a device for intratumoral (i.t.) injection. METHODS:Gd-nanoCPs were prepared by a novel emulsion-droplet coalescence technique. The effects...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1018995124527

    authors: Tokumitsu H,Ichikawa H,Fukumori Y

    更新日期:1999-12-01 00:00:00

  • Polymer chemistry influences monocytic uptake of polyanhydride nanospheres.

    abstract:PURPOSE:To demonstrate that polyanhydride copolymer chemistry affects the uptake and intracellular compartmentalization of nanospheres by THP-1 human monocytic cells. METHODS:Polyanhydride nanospheres were prepared by an anti-solvent nanoprecipitation technique. Morphology and particle diameter were confirmed via scan...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-008-9760-7

    authors: Ulery BD,Phanse Y,Sinha A,Wannemuehler MJ,Narasimhan B,Bellaire BH

    更新日期:2009-03-01 00:00:00

  • Lack of Association of Generic Brittle Status with Genetics and Physiologic Measures in Patients with Epilepsy.

    abstract:PURPOSE:A patient was denoted to be generic brittle (GB) if they had a negative opinion about generics (e.g. prior history of a switch problem) or took the innovator brand of their most problematic anti-epileptic drug (AED) when generic was available. The aim of this hypothesis-generating study was to assess possible g...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-020-2781-6

    authors: Das S,Guo D,Jiang X,Jiang W,Shu Y,Ting TY,Polli JE

    更新日期:2020-02-26 00:00:00

  • Mechanistic studies on effervescent-induced permeability enhancement.

    abstract:PURPOSE:To determine the mechanism(s) by which effervescence induces penetration enhancement of a broad range of compounds ranging in size, structure, and other physiocochemical properties across rat and rabbit small intestinal epithelium. METHODS:Effervescent induced penetration enhancement was investigated in vitro ...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1011936901638

    authors: Eichman JD,Robinson JR

    更新日期:1998-06-01 00:00:00

  • Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology.

    abstract::The absorption of insulin across the vaginal mucosa into the systemic circulation was studied in ovariectomized rats given subsequent estrogen treatment. Blood glucose levels were determined as an indirect measure of insulin absorption, and the effect of various enhancers on the hypoglycemic response was investigated....

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1015892630637

    authors: Richardson JL,Illum L,Thomas NW

    更新日期:1992-07-01 00:00:00

  • Factors affecting the stability of nanoemulsions--use of artificial neural networks.

    abstract:PURPOSE:The aim of this study was to identify the dominant factors affecting the stability of nanoemulsions, using artificial neural networks (ANNs). METHODS:A nanoemulsion preparation of budesonide containing polysorbate 80, ethanol, medium chain triglycerides and saline solution was designed, and the particle size o...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-009-0004-2

    authors: Amani A,York P,Chrystyn H,Clark BJ

    更新日期:2010-01-01 00:00:00

  • Increased erythropoietin elimination in fetal sheep following chronic phlebotomy.

    abstract:PURPOSE:To determine by pharmacokinetic (PK) means the role of erythropoietin-receptor (EPO-R) upregulation in fetuses on the elimination of erythropoietin (EPO). MATERIALS AND METHODS:Six fetal sheep were catheterized at a gestational age of 125-127 days and phlebotomized daily for 6 days. Paired tracer PK studies us...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-007-9295-3

    authors: Freise KJ,Widness JA,Segar JL,Schmidt RL,Veng-Pedersen P

    更新日期:2007-09-01 00:00:00

  • Transfollicular drug delivery.

    abstract::The hair follicle, hair shaft, and sebaceous gland collectively form what is recognized as the pilosebaceous unit. This complex, three-dimensional structure within the skin possesses a unique biochemistry, metabolism and immunology. Recent studies have focused on the hair follicle as a potential pathway for both local...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章,评审

    doi:10.1023/a:1016250422596

    authors: Lauer AC,Lieb LM,Ramachandran C,Flynn GL,Weiner ND

    更新日期:1995-02-01 00:00:00

  • Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis.

    abstract:PURPOSE:Simvastatin (SIM), a HMG-CoA reductase inhibitor widely prescribed for hypercholesterolemia, has been reported to ameliorate inflammation and promote osteogenesis. Its clinical applications on these potential secondary indications, however, have been hampered by its lack of osteotropicity and poor water solubil...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-018-2444-z

    authors: Wang X,Jia Z,Almoshari Y,Lele SM,Reinhardt RA,Wang D

    更新日期:2018-06-25 00:00:00

  • Surface modification of pharmaceutical nanocarriers with ascorbate residues improves their tumor-cell association and killing and the cytotoxic action of encapsulated paclitaxel in vitro.

    abstract:PURPOSE:To evaluate the potential of ascorbate as a novel ligand in the preparation of pharmaceutical nanocarriers with enhanced tumor-cell specific binding and cytotoxicity. METHODS:Palmitoyl ascorbate was incorporated into liposomes at varying concentrations. A stable formulation was selected based on size and zeta ...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-008-9674-4

    authors: D'Souza GG,Wang T,Rockwell K,Torchilin VP

    更新日期:2008-11-01 00:00:00

  • Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing.

    abstract:PURPOSE:This study addresses the effect of freezing and thawing on a therapeutic monoclonal antibody (mAb) solution and the corresponding buffer formulation. Particle formation, crystallization behaviour, morphology changes and cryo-concentration effects were studied after varying the freezing and thawing rates, buffer...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-018-2378-5

    authors: Hauptmann A,Podgoršek K,Kuzman D,Srčič S,Hoelzl G,Loerting T

    更新日期:2018-03-19 00:00:00

  • Saquinavir Loaded Acetalated Dextran Microconfetti - a Long Acting Protease Inhibitor Injectable.

    abstract:PURPOSE:Since the adoption of highly active antiretroviral therapy, HIV disease progression has slowed across the world; however, patients are often required to take multiple medications daily of poorly bioavailable drugs via the oral route, leading to gastrointestinal irritation. Recently, long acting antiretroviral i...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-016-1936-y

    authors: Collier MA,Gallovic MD,Bachelder EM,Sykes CD,Kashuba A,Ainslie KM

    更新日期:2016-08-01 00:00:00

  • Development of delta opioid peptides as nonaddicting analgesics.

    abstract::Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015809702296

    authors: Rapaka RS,Porreca F

    更新日期:1991-01-01 00:00:00

  • Effect of treatment regimen on the immunogenicity of human interferon Beta in immune tolerant mice.

    abstract:PURPOSE:Interferon beta is commonly used as therapeutic in the first line of therapy for multiple sclerosis. However, depending on the product, it induces an antibody response in up to 60% of patients. This study evaluated the impact of therapy related factors like dose, route of administration and administration frequ...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1007/s11095-013-0992-9

    authors: Kijanka G,Jiskoot W,Schellekens H,Brinks V

    更新日期:2013-06-01 00:00:00

  • Characterization of oil-in-water emulsions prepared from solid-state emulsions: effect of matrix and oil phase.

    abstract::Emulsions (o/w) were prepared from solid-state emulsions comprised of various matrix materials and oils and the resultant particle size properties determined. Results suggest that for those matrices that can form solid-state emulsions, the droplet size decreased as a function of time, as previously observed. The final...

    journal_title:Pharmaceutical research

    pub_type: 杂志文章

    doi:10.1023/a:1018912100826

    authors: Shively ML

    更新日期:1993-08-01 00:00:00