Abstract:
:Fourier transform infrared (FTIR) microspectroscopic imaging and small angle x-ray scattering (SAXS) were combined to investigate the supramolecular structure of collagen from 27 tissue sections from patients undergoing mastectomy, excisional biopsy, or mammoplasty. Both techniques were correlated by matching the scattering profile from the SAXS data with the integrated area of the infrared collagen region (1300-1180 cm(-1)). The FTIR spectral profiles and multivariate analysis of various tissue components showed consistent differences between all major tissue components, particularly between cancer and normal tissue cells. Analysis of the SAXS data revealed broad differences between cancer and normal tissue, but were inconclusive due to the small sample size. Parameters were extracted from each technique in relation to their characterization of collagen to reveal a good correlation between the two techniques, which diagnostically parallels with gold-standard Hematoxylin and Eosin (H&E) stained sections. The results show that the integrated area of collagen region in the FTIR spectrum for cancerous samples is greater than that for noncancerous samples indicating collagen disorder. This supports the notion that collagen is structurally disrupted in cancer tissue consistent with the interpretation of the SAXS data. Overall, both these techniques successfully distinguished cancer from normal breast tissue. Integration of these two techniques was able to better segregate cancer as well as provide a more complete understanding of the differences in collagen on all structural levels during breast cancer development.
journal_name
Med Physjournal_title
Medical physicsauthors
Ooi GJ,Fox J,Siu K,Lewis R,Bambery KR,McNaughton D,Wood BRdoi
10.1118/1.2890391subject
Has Abstractpub_date
2008-05-01 00:00:00pages
2151-61issue
5eissn
0094-2405issn
2473-4209journal_volume
35pub_type
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