A novel immunosuppressive pathway involving peroxynitrite-mediated [corrected] nitration of platelet antigens within antigen-presenting cells.

abstract：BACKGROUND:In spite of interventions, approximately 1000 per 1,000,000 platelet (PLT) collections are contaminated with bacteria at collection. The current prestorage culture procedure at some blood centers is to inoculate a fixed volume from the collection bag (4-8 mL) regardless of collection volume. The sensitivity ...

journal_title：Transfusion

authors： Tomasulo PA,Wagner SJ

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Febrile nonhemolytic transfusion reaction (FNHTR) has been identified as a pivotal reason for prestorage universal WBC reduction. A regional blood center implemented universal prestorage WBC reduction for RBCs on January 1, 2000. Whether prestorage universal WBC reduction of RBC units will affect FNHTR is no...

journal_title：Transfusion

authors： Uhlmann EJ,Isgriggs E,Wallhermfechtel M,Goodnough LT

更新日期：2001-08-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is used as a cryoprotective agent when platelets are frozen. We examined the effect of DMSO (0.1 to 10%) on platelet aggregation, release, and prostaglandin synthesis (as indicated by malondialdehyde formation) in response to thrombin, collagen, arachidonic acid and calcium ionophore. Inhibit...

journal_title：Transfusion

authors： Fratantoni JC,Poindexter BJ

更新日期：1983-03-01 00:00:00

abstract：:A 20-year-old man with chronic granulomatous disease (CGD) and who was receiving granulocyte transfusions for a refractory liver abscess was studied to compare the kinetics of 111In-labeled granulocytes with those of two functional granulocyte assays, nitroblue tetrazolium reduction and chemiluminescence. Transfused g...

journal_title：Transfusion

authors： Elliott GR,Clay ME,Mills EL,Abramson JS,McCullough J,Quie PG

更新日期：1987-01-01 00:00:00

abstract：:This article introduces a new method of component preparation that is capable of producing white cell (WBC)-reduced platelet concentrates (PCs) from whole blood. Whole blood is separated into packed red cells (RBCs) and platelet-rich plasma (PRP) by centrifugation, and the PRP is expressed through a newly designed WBC...

journal_title：Transfusion

authors： Dzik WH,Cusack WF,Gacek MJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Diclofenac has frequently been implicated as the cause of immune hemolytic anemias and less frequently of immune thrombocytopenia. The presence of the causative antibodies has only been demonstrated in patients with immune hemolytic anemia, but not yet in patients with thrombocytopenia. The cases of two pati...

journal_title：Transfusion

authors： Meyer O,Hoffmann T,Aslan T,Ahrens N,Kiesewetter H,Salama A

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies against fetal human platelet antigens (HPAs), mostly caused by anti-HPA-1a. Population-based screening for FNAIT is still a topic of debate. Logistically and financially, the major challenge for implementation is the ...

journal_title：Transfusion

authors： Winkelhorst D,Porcelijn L,Muizelaar E,Oldert G,Huiskes E,van der Schoot CE

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Brucellosis is a severe zoonotic disease that is increasingly prevalent in north China. A study evaluating Brucella infection in blood donors was conducted at Kashi central blood station, Xinjiang, China. STUDY DESIGN AND METHODS:Four serologic and two molecular methods of detection of Brucella infection we...

journal_title：Transfusion

authors： Wang W,Liao Q,Wu X,Hou S,Wang Y,Wu J,Shen C,Chen S,Allain JP,Li C

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Anti-IH is usually a clinically insignificant antibody that may complicate a serologic workup. However, it can occasionally cause hemolysis. We report a rare case of acute hemolysis caused by anti-IH. CASE REPORT:A 60-year-old man with a long history of chronic myelomonocytic leukemia and anemia, blood grou...

journal_title：Transfusion

authors： Irani MS,Richards C

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Platelets pose the greatest transfusion-transmitted infectious risk among blood products. Refrigeration of platelets can mitigate bacterial contamination and extend platelet shelf life. Implementation of pathogen reduction technologies (PRTs) at blood banks has become increasingly popular to protect against ...

journal_title：Transfusion

authors： Agey A,Reddoch-Cardenas K,McIntosh C,Sharma U,Cantu C,Cap A,Bynum J

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:At most US blood centers, patients may still opt to choose specific donors to give blood for their anticipated transfusion needs. However, there is little evidence of improved safety with directed donation when compared to volunteer donation. STUDY DESIGN AND METHODS:The percentage of directed donations mad...

journal_title：Transfusion

authors： Dorsey KA,Moritz ED,Steele WR,Eder AF,Stramer SL

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:There are no reports in the transfusion medicine literature that describe adverse reactions and donor arm injuries after whole-blood donation based on solicited information. STUDY DESIGN AND METHODS:The present study solicited adverse reaction and donor arm injury information from 1000 randomly selected who...

journal_title：Transfusion

authors： Newman BH,Pichette S,Pichette D,Dzaka E

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Red blood cell (RBC) units stored for more than 2 weeks at 4 degrees C are currently considered of impaired quality. This opinion has primarily been based on altered RBC rheologic properties (i.e., enhanced aggregability, reduced deformability, and elevated endothelial cell interaction), during prolonged sto...

journal_title：Transfusion

authors： Henkelman S,Dijkstra-Tiekstra MJ,de Wildt-Eggen J,Graaff R,Rakhorst G,van Oeveren W

更新日期：2010-04-01 00:00:00

abstract：:The effects of hydroxyethyl starch (HES) on hemostasis were investigated extensively. In order to simulate acute blood loss due to surgery or trauma, one unit (450 ml) of blood was drawn from normal healthy men. This was followed by a 1-liter infusion over 60 minutes of either 6 percent HES, 5 percent albumin, or 0.9 ...

journal_title：Transfusion

authors： Stump DC,Strauss RG,Henriksen RA,Petersen RE,Saunders R

更新日期：1985-07-01 00:00:00

abstract：:The supernatant plasma which remains after cryoprecipitation is a useful component for transfusion therapy. However, from prior studies it was unclear how well plasma clotting factors were preserved following cryoprecipitation. Coagulation factor assays were performed on fresh plasma, supematant plasma after removal o...

journal_title：Transfusion

authors： Roth GJ,Tobias KI

更新日期：1974-03-01 00:00:00

abstract：BACKGROUND:With the coronavirus disease 2019 (COVID-19) pandemic continuing to accelerate and blood collection agencies (BCAs) warning of shortages, it is critical to identify the current determinants of donor behavior for donors and nondonors. STUDY DESIGN AND METHODS:In May and June 2020, Australian residents who be...

journal_title：Transfusion

authors： Masser BM,Hyde MK,Ferguson E

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Current national standards for pretransfusion testing do not address the frequency or optimal time interval to repeat antibody identification testing for patients in whom antibodies have been previously detected. STUDY DESIGN AND METHODS:A retrospective review was performed of patients with existing red blo...

journal_title：Transfusion

authors： Dinh A,Eliason K,Dzik WS

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:In the Rh blood group system, variant RhD and RhCE express several partial antigens. We investigated RH in samples with partial DIVa that demonstrated weak and variable reactivity with anti-C. STUDY DESIGN AND METHODS:Standard hemagglutination techniques, polymerase chain reaction-based assays, and RH seque...

journal_title：Transfusion

authors： Westhoff CM,Vege S,Halter Hipsky C,Hue-Roye K,Copeland T,Velliquette RW,Horn T,Lomas-Francis C,Reid ME

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:A size-exclusion filter (Viresolve 180, Millipore Corp.) was tested for its ability to remove transmissible spongiform encephalopathies prion protein from an immune globulin preparation during ultrafiltration. STUDY DESIGN AND METHODS:Hamster-adapted 263K scrapie brain homogenate (SBH) was spiked into Rh0(D...

journal_title：Transfusion

authors： Van Holten RW,Autenrieth S,Boose JA,Hsieh WT,Dolan S

更新日期：2002-08-01 00:00:00

abstract：:Ultraviolet B (UVB) irradiation of platelet concentrates (PCs) may prevent the development of posttransfusion HLA alloimmunization. As irradiation performed in a blood center or a hospital will probably be associated with a variable postirradiation delay before transfusion, the ability to store PCs after UVB irradiati...

journal_title：Transfusion

authors： Snyder EL,Beardsley DS,Smith BR,Horne W,Johnson R,Wooten T,Napychank PA,Male P,Buchholz DH

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Recently, long-standing elevations of soluble growth factors released from platelets (PLTs) after contact with artificial surfaces during dialysis were described. They could be jointly responsible for the high frequency of death from cardiovascular diseases in dialysis patients. There are no comparable data ...

journal_title：Transfusion

authors： Zimmermann R,Loew D,Weisbach V,Strasser E,Ringwald J,Zingsem J,Eckstein R

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted in improvements. Mortality and c...

journal_title：Transfusion

authors： Edgren G,Tran TN,Hjalgrim H,Rostgaard K,Shanwell A,Titlestad K,Wikman A,Norda R,Jersild C,Wideroff L,Gridley G,Adami J,Melbye M,Nyrén O,Reilly M

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The platelet (PLT) Pan Genera Detection test (PGD) is a rapid bacterial detection system used to screen PLTs for bacterial contamination. We report a single center 46-month experience with secondary screening of apheresis PLTs by PGD testing. STUDY DESIGN AND METHODS:Existing testing records of apheresis PL...

journal_title：Transfusion

authors： Dunbar NM,Kreuter JD,Marx-Wood CR,Dumont LJ,Szczepiorkowski ZM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Identification of antibodies against high-prevalence Scianna (Sc; ERMAP) antigens, like Sc1 and Sc5, is difficult and may incur delays in blood procurement and costs. The detection of additional clinically significant alloantibodies is hampered in the presence of anti-Scianna. Soluble recombinant Scianna pro...

journal_title：Transfusion

authors： Seltsam A,Grueger D,Blasczyk R,Flegel WA

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Most alloantigens on transfused red blood cells (RBCs) are weakly immunogenic, with only a 2 to 6 percent overall immunization rate even in patients receiving multiple transfusions. Although recipient genetics may contribute to responder and/or nonresponder status, in most cases HLA type does not predict hum...

journal_title：Transfusion

authors： Hendrickson JE,Desmarets M,Deshpande SS,Chadwick TE,Hillyer CD,Roback JD,Zimring JC

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Treating hemorrhage with blood transfusions in subjects previously hemodiluted with different colloidal plasma expanders, using fresh autologous blood or blood that has been stored for 2 weeks, allows identifying the interaction between type of plasma expander and differences in blood storage. STUDY DESIGN ...

journal_title：Transfusion

authors： Hightower CM,Salazar Vázquez BY,Cabrales P,Tsai AG,Acharya SA,Intaglietta M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The Joint Commission has highlighted the importance of having appropriate and complete pretransfusion testing before surgery begins. The maximum surgical blood ordering schedule (MSBOS) indicates which patients require preoperative transfusion testing. We determined the number of times surgical delays were c...

journal_title：Transfusion

authors： McWilliams B,Yazer MH,Cramer J,Triulzi DJ,Waters JH

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The use of blood-saving techniques in elective surgery can produce a favorable cost-benefit ratio only when there is a reasonable likelihood that transfusion will be required. To apply a targeted blood-sparing technique in lung cancer surgery, the patient's preoperative characteristics that predict the use o...

journal_title：Transfusion

authors： Cirasino L,Barosi G,Torre M,Crespi S,Colombo P,Belloni PA

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Monitoring of patients' vital sign values (VSVs) during hemotherapy may have an important role in the recognition and mitigation of transfusion-associated circulatory overload (TACO). Knowledge regarding VSVs and other patient characteristics in bedside-reported TACO or fluid challenge-suspected transfusion ...

journal_title：Transfusion

authors： Andrzejewski C Jr,Popovsky MA,Stec TC,Provencher J,O'Hearn L,Visintainer P,Steingrub J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:By consensus definition, the red blood cells (RBCs) of patients that react weak to 2+ in the serologic D test are classified as having the serologic weak D phenotype (weak D). The risk of D alloimmunization in patients with weak D is not well studied. This study retrospectively determined the incidence of D ...

journal_title：Transfusion

authors： Yazer MH,Brunker PA,Bakdash S,Tobian AA,Triulzi DJ,Earnest V,Harris S,Delaney M

更新日期：2016-10-01 00:00:00