The effects of amiodarone on the electrocardiogram of the guinea-pig are not explained by interaction with thyroid hormone metabolism alone.

abstract：BACKGROUND AND PURPOSE:Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to block PAR2 signalling associated with disease without inhibiting PAR2 activation in normal physiology could be provided by studies of biased signalling. EXPERIMENT...

journal_title：British journal of pharmacology

authors： Suen JY,Cotterell A,Lohman RJ,Lim J,Han A,Yau MK,Liu L,Cooper MA,Vesey DA,Fairlie DP

更新日期：2014-09-01 00:00:00

abstract：:1 The concentrations of p- and m-tyramine, dopamine and homovanillic acid were measured in the mouse striatum following the subcutaneous administration of amfonelic acid, (+)-amphetamine or nomifensine.2 The administration of 2.5-25 mg/kg of amfonelic acid produced a reduction in p-tyramine that lasted at least 8 h. m...

journal_title：British journal of pharmacology

authors： Juorio AV

更新日期：1982-11-01 00:00:00

abstract：:Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring the safety of clinical trial subjects or patients. Present methodologies for assessing drug-induced torsades de pointes (TdP) a...

journal_title：British journal of pharmacology

authors： Bass AS,Darpo B,Breidenbach A,Bruse K,Feldman HS,Garnes D,Hammond T,Haverkamp W,January C,Koerner J,Lawrence C,Leishman D,Roden D,Valentin JP,Vos MA,Zhou YY,Karluss T,Sager P

更新日期：2008-08-01 00:00:00

abstract：:1. Noradrenaline sensitivity and acetylcholine-induced relaxation were investigated in mesenteric resistance arteries from female Wistar rats (220-250 g) following exposure to isotonic supraphysiological glucose solutions (20 and 45 mM, in physiological buffer, 2 h incubation). 2. Arteries incubated in 20 mM glucose d...

journal_title：British journal of pharmacology

authors： Taylor PD,Poston L

更新日期：1994-11-01 00:00:00

abstract：:1. Murine left atrium lacks inotropic beta(2)-adrenoceptor function. We investigated whether beta(2)-adrenoceptors are involved in the cardiostimulant effects of (-)-adrenaline on spontaneously beating right atria and paced right ventricular myocardium of C57BL6 mice. We also studied a negative inotropic effect of (-)...

journal_title：British journal of pharmacology

authors： Heubach JF,Rau T,Eschenhagen T,Ravens U,Kaumann AJ

更新日期：2002-05-01 00:00:00

abstract：:1. Angiotensin-converting enzyme (ACE) inhibitors exert their cardiovascular effects not only by preventing the formation of angiotensin II (AII), but also by promoting the accumulation of bradykinin in or at the vessel wall. In addition, certain ACE inhibitors have been shown to augment the vasodilator response to br...

journal_title：British journal of pharmacology

authors： Hecker M,Blaukat A,Bara AT,Müller-Esterl W,Busse R

更新日期：1997-08-01 00:00:00

abstract：:1. The effects of flecainide alone, mexiletine alone and their combination at the Na+ channel level were studied in guinea-pig papillary muscles. The maximum upstroke velocity (Vmax) was used as an indirect index of the magnitude of the fast inward Na+ current (INa). 2. In muscles driven at 0.02 Hz, neither mexiletine...

journal_title：British journal of pharmacology

authors： Delpón E,Valenzuela C,Tamargo J

更新日期：1991-06-01 00:00:00

abstract：:1. Neurally-evoked output of newly synthesized [3H]-acetylcholine from the rat phrenic nerve was measured in the absence of cholinesterase inhibitors. 2. Noradrenaline and isoprenaline enhanced neurally-evoked transmitter output markedly. Moreover, immediately after the application of noradrenaline the basal tritium e...

journal_title：British journal of pharmacology

authors： Wessler I,Anschütz S

更新日期：1988-07-01 00:00:00

abstract：:The S-S reducing agent, dithiothreitol (DTT) altered the properties of nicotinic receptors in rat superior cervical ganglia such that (i) carbachol became less active as a depolarizing agent and (ii) bromo-acetylcholine produced an irreversible depolarization. The latter was temporarily annulled by hexamethonium (whic...

journal_title：British journal of pharmacology

authors： Brown DA,Kwiatkowski D

更新日期：1976-01-01 00:00:00

abstract：:1. The efflux and influx of tryptophan across the synaptosomal plasma membrane has been studied under a variety of experimental conditions, in order to examine the mechanism by which depolarization enhances the efflux of tryptophan from superfused synaptosomes. 2. Efflux of [3H]-tryptophan from preloaded superfused sy...

journal_title：British journal of pharmacology

authors： Collard KJ,Wilkinson LS,Lewis DJ

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The effects of systemic treatment with indomethacin-loaded nanocapsules (IndOH-NC) were compared with those of free indomethacin (IndOH) in rat models of acute and chronic oedema. EXPERIMENTAL APPROACH:The following models of inflammation were employed: carrageenan-induced acute oedema (measured...

journal_title：British journal of pharmacology

authors： Bernardi A,Zilberstein AC,Jäger E,Campos MM,Morrone FB,Calixto JB,Pohlmann AR,Guterres SS,Battastini AM

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:(R,S)-ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment-resistant bipolar depression (BD). The genetic, pharmacological and biochemical differences between ketamine responders and non-responders have not been identified. The p...

journal_title：British journal of pharmacology

authors： Villaseñor A,Ramamoorthy A,Silva dos Santos M,Lorenzo MP,Laje G,Zarate C Jr,Barbas C,Wainer IW

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence has pinpointed a specific mitochondrial action of efavirenz accompanied by the induction of an endo...

journal_title：British journal of pharmacology

authors： Polo M,Alegre F,Funes HA,Blas-Garcia A,Victor VM,Esplugues JV,Apostolova N

更新日期：2015-04-01 00:00:00

abstract：:1. Under normal experimental conditions, the rabbit isolated distal saphenous artery appears to contain a homogeneous population of postjunctional alpha 1-adrenoceptors. Prazosin competitively antagonized responses to noradrenaline (NA) with a pA2 value of 8.6, while a relatively high concentration of rauwolscine (1 m...

journal_title：British journal of pharmacology

authors： Dunn WR,McGrath JC,Wilson VG

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The thiazolidine carboxylic acid, BML-241, has been proposed as a lead compound in development of selective antagonists at the sphingosine-1-phosphate receptor (S1P3), based on its inhibition of the rise in intracellular calcium concentrations ([Ca2+]i) in HeLa cells overexpressing S1P receptors....

journal_title：British journal of pharmacology

authors： Jongsma M,Hendriks-Balk MC,Michel MC,Peters SL,Alewijnse AE

更新日期：2006-10-01 00:00:00

abstract：:1. In order to clarify the mechanism of Ca-dependent excitatory action of maitotoxin (MTX), the most potent marine toxin known, patch-clamp techniques were used to analyse electrophysiological effects of MTX on guinea-pig isolated cardiac myocytes. 2. The whole-cell recordings showed that MTX (0.3 ng ml-1) produced a ...

journal_title：British journal of pharmacology

authors： Kobayashi M,Ochi R,Ohizumi Y

更新日期：1987-11-01 00:00:00

abstract：:1. The inhibitory effects of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on mean arterial pressure (MAP) responses to NG-nitro-L-arginine (L-NNA) (NO synthase inhibitor), angiotensin II (AII) and noradrenaline (NA) were compared with those of pinacidil (KATP channel opener) and nifedipine (L-type calcium an...

journal_title：British journal of pharmacology

authors： Wang YX,Zhou T,Pang CC

更新日期：1993-02-01 00:00:00

abstract：UNLABELLED:Sensory neurons play important roles in many disorders, including inflammatory diseases, such as sepsis. Sepsis is a potentially lethal systemic inflammatory reaction to a local bacterial infection, affecting thousands of patients annually. Although associated with a high mortality rate, sepsis outcome depen...

journal_title：British journal of pharmacology

authors： Bodkin JV,Fernandes ES

更新日期：2013-12-01 00:00:00

abstract：:1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated phospholipase C activity was determined by mas...

journal_title：British journal of pharmacology

authors： Pyne S,Pyne NJ

更新日期：1993-09-01 00:00:00

abstract：:1. The effects of diprafenone and propafenone on transmembrane action potential were examined and compared in papillary muscles and single ventricular myocytes isolated from guinea-pig hearts. 2. In papillary muscles, both diprafenone and propafenone > or = 10(-6) M caused a significant and dose-dependent decrease in ...

journal_title：British journal of pharmacology

authors： Kodama I,Suzuki R,Honjo H,Toyama J

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Anandamide (AEA) activates both cannabinoid CB(1) and TRPV1 receptors, which are expressed on cultured dorsal root ganglion neurones. Increased levels of nerve growth factor (NGF) are associated with chronic pain states. EXPERIMENTAL APPROACH:The aim of this study was to compare of the effects of AEA on CB(...

journal_title：British journal of pharmacology

authors： Evans RM,Scott RH,Ross RA

更新日期：2007-10-01 00:00:00

abstract：:1. The present study has compared the relative anti-aggregatory effect of various compounds which interfere with thromboxane (Tx) A2-dependent aggregation of human platelets in whole blood in vitro. These included the cyclo-oxygenase inhibitor aspirin, the TxA2 synthase inhibitor dazoxiben, the TxA2 (TP-) receptor blo...

journal_title：British journal of pharmacology

authors： Watts IS,Wharton KA,White BP,Lumley P

更新日期：1991-02-01 00:00:00

abstract：:The sequence similarity within the amino-terminal regions of parathyroid hormone (PTH) and PTH-related protein (PTHrP) allows the two to share actions at a common site, the PTH1 receptor. A number of biological activities have been ascribed to actions of other domains within PTHrP. PTHrP production by late stage breas...

journal_title：British journal of pharmacology

authors： Martin TJ,Johnson RW

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND AND PURPOSE:Although there are many new specific phosphodiesterase inhibitors with anti-inflammatory activity, none have yet reached the market because of their low therapeutic efficacy. Our study was aimed to evaluate the anti-inflammatory and anti-arthritic effect of an established phosphodiesterase inhibi...

journal_title：British journal of pharmacology

authors： Gomaa A,Elshenawy M,Afifi N,Mohammed E,Thabit R

更新日期：2009-12-01 00:00:00

abstract：:1. Acetylcholine mustard (N-2-chloroethyl-N-methyl-2-acetoxyethylamine), a potent muscarinic agonist, binds virtually irreversibly to muscarinic receptors in longitudinal muscle strips from guinea-pig small intesting, as shown by the inhibition of the binding of E13-H]-propylbenzilycholine mustard ([3-H-PrBCM), an aff...

journal_title：British journal of pharmacology

authors： Robinson DA,Taylor JG,Young JM

更新日期：1975-03-01 00:00:00

abstract：:1. Tyrosine kinases have been proposed as regulators of voltage-operated calcium channels. The effects of a range of structurally different inhibitors of protein tyrosine kinases (PTK) were examined on voltage-operated calcium channel currents (I(Ba)) and pp60(c-src) kinase (c-src) activity in vitro. 2. I(Ba) was meas...

journal_title：British journal of pharmacology

authors： Wijetunge S,Lymn JS,Hughes AD

更新日期：2000-04-01 00:00:00

abstract：:1. The effects of NS 1619, the putative BKCa channel opener, were investigated on rat intact portal veins and on single smooth muscle cells enzymatically separated from the same tissue. 2. Under whole-cell patch clamp conditions with K-rich pipettes, exposure of single cells held at -10 mV to NS 1619 (10-33 microM) in...

journal_title：British journal of pharmacology

authors： Edwards G,Niederste-Hollenberg A,Schneider J,Noack T,Weston AH

更新日期：1994-12-01 00:00:00

abstract：:1. The present study was designed to investigate tolerance to several pharmacological effects of apomorphine. 2. Changes in blood pressure, heart rate, plasma noradrenaline levels, rectal temperature, respiratory rate and retching plus vomiting were compared after administration of apomorphine (200 micrograms kg-1, i....

journal_title：British journal of pharmacology

authors： Montastruc JL,Llau ME,Senard JM,Tran MA,Rascol O,Montastruc P

更新日期：1996-03-01 00:00:00

abstract：:1. Comparison of the rank order of potency of the natural prostanoids prostaglandin E2 (PGE2), PGD2, PGF2 alpha and carbaprostacyclin in stimulating cyclic AMP in Jurkat cells is consistent with the presence of an EP receptor. 2. Lack of responsiveness to the EP1/EP3 selective agonist, sulprostone, and the EP2 agonist...

journal_title：British journal of pharmacology

authors： De Vries GW,Guarino P,McLaughlin A,Chen J,Andrews S,Woodward DF

更新日期：1995-08-01 00:00:00

abstract：:1. We have investigated the mechanism of smooth muscle contraction evoked by activation of 5-HT1-like receptors in dog isolated saphenous vein. 2. In the presence of the 5-HT2 receptor antagonist, ritanserin (0.1 microM), concentration-effect curves (10 nM-300 microM) for 5-hydroxytryptamine (5-HT)-induced smooth musc...

journal_title：British journal of pharmacology

authors： Sumner MJ,Feniuk W,McCormick JD,Humphrey PP

更新日期：1992-03-01 00:00:00