Abstract:
:Ten healthy volunteers were studied to find out whether tachyphylaxis occurs on repeated application of topical steroids. The Singh and Singh modification of the Reddy and Singh (1976) technique was used. Fluocinolone acetonide cream (0.1%) under occlusion was applied daily for 14 days on the flexor aspect of the forearms. The wheal was induced by pricking with histamine acid phosphate solution and the volume of the wheal produced was calculated. The test was repeated on the same sites on alternate days for 14 days. The maximum wheal suppression, which gradually diminished, was observed on the 8th day. By the 14th day, there was practically total tolerance to topical steroid, which showed minimal suppression of histamine wheal formation. This confirms the occurrence of the phenomenon of tachyphylaxis by different experimental techniques.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Singh G,Singh PKdoi
10.1111/j.1365-4362.1986.tb02258.xsubject
Has Abstractpub_date
1986-06-01 00:00:00pages
324-6issue
5eissn
0011-9059issn
1365-4632journal_volume
25pub_type
临床试验,杂志文章abstract:BACKGROUND:Chemotherapy-induced acral erythema is a distinct localized cutaneous response to certain systemic chemotherapeutic agents. METHODS:Between January 1990 and December 1994, from a total of 76 leukemic patients who have received combination chemotherapy consisting of cytosine arabinoside and anthracycline ant...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1997.00040.x
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate possible associations of the five DNA polymorphic genotypes in the HLA region (transporter associated with antigen processing [TAP1; TAP1 333 a/b, TAP1 637 c/d], the HLA-DRB1*1501-rs3135388, tumor necrosis factor [TNF]α [-238 G/A] and NcoI TNFβ) with characteristics o...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12213
更新日期:2013-08-01 00:00:00
abstract::A 34-year-old man presented with a large cutaneous lesion on his left thigh that had started as a small papule when he was 13 years of age. The lesion had enlarged slowly over the last 21 years. The patient had received bacillus Calmette-Guérin (BCG) vaccination in childhood. The family history was significant for tub...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00095-4.x
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS:T...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13482
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the presence of anti-Dsg1 and Dsg3 antibodies in healthy subjects of the high Peruvian Amazon (Tuemal, Rodriguez de Mendoza province, department of Amazonas) to establish the theoretical presence of environmental factors or triggers in the area. MATERIALS AND MET...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13824
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical-looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13711
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is a common inflammatory skin disease resulting from the interplay between environmental, immunological and genetic factors. In our study, we investigated the role of three single nucleotide polymorphisms (SNPs) at 5'-UTR of DEFB1 gene, encoding for the human beta defensin-1, on the su...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04343.x
更新日期:2010-06-01 00:00:00
abstract::A 47-year-old male developed both longitudinal melanonychia and periungual hyperpigmentation 6 months after initiation of hydroxycarbamide (synonym: hydroxyurea) therapy for chronic myeloproliferative disease. Based on the clinical symptoms observed in this patient, the broad differential diagnostic spectrum of hyperp...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03502.x
更新日期:2007-11-01 00:00:00
abstract::Topical anthralin application producing a brisk irritant contact dermatitis has been reported to have therapeutic benefit in alopecia areata. A pilot clinical study was undertaken to determine whether topical anthralin application in doses low enough to produce only minimal contact dermatitis would produce a similar t...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1985.tb05863.x
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:'"Inflammatory vitiligo" cases with clear lichenoid infiltrates have been reported. However, the inflammatory nature of common vitiligo has not gained wide acceptance because of its benign appearance and scanty cellular infiltrates. We have observed in our patients a few lesions with mild erythema, scaling a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03672.x
更新日期:2008-07-01 00:00:00
abstract::In 107 cases of facial contact dermatitis, routine Finn chamber epicutaneous tests with TROLAB European Standard Allergens (ESAs) were performed. Sixty-one (57%) had positive reaction. The most frequent contact allergens were paraphenylenediamine dihydrochloride (16%), followed by fragrance mix (15%), and nickel sulfa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb04867.x
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05408.x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Psoriasis has been associated with depressive disease and case reports of completed suicide. METHODS:217 consenting psoriasis patients completed the Carroll Rating Scale for Depression (CRSD), a 52-item self-rated scale, with four of the items directly addressing wishes to be dead and suicidal ideation. The...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb02790.x
更新日期:1993-03-01 00:00:00
abstract::Pellagra secondary to antituberculous chemotherapy can result from isoniazide therapy, as well as from pyrazinamide treatment. Because of the similarity in structural formulas between pyrazinamide, isoniazide, and nicotinamide, the substrate competition is the mechanism most likely involved. The patient was cured by a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1983.tb02114.x
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:With increasing levels of solar ultraviolet radiation (UVR) in the earth's near environment and evidence that exposure to UVR contributes to skin cancer, cataracts, and photoaging, protection of the skin is imperative during exposure to the sun. The purpose of this study was to examine the effectiveness of v...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1997.00046.x
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Leishmania coinfection is frequently seen in human immunodeficiency virus (HIV)-infected patients in endemic areas, and from time to time the protozoan is detected in cutaneous biopsies. OBJECTIVE:To establish the characteristics and possible ethiologic role of the presence of Leishmania in these lesions. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2002.01610.x
更新日期:2002-10-01 00:00:00
abstract::Mycetoma is a chronic subcutaneous fungal infection characterized by tumefaction, draining sinuses, and grains. It is most common in the tropics but occasionally occurs in the United States. We report a case of a mycetoma affecting the foot of a 38-year-old mentally retarded man from northern New England. The causal o...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02382.x
更新日期:1988-07-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tum...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14637
更新日期:2020-02-01 00:00:00
abstract::Twenty-eight psoriatic patients received PUVA treatment (psoralen and long ultraviolet irradiations. Two preparations were used; 8-methoxypsoralen and a mixture of 5-methoxypsoralen and 8-methoxypsoralen. Both gave considerable improvement, but in 6 cases the lesions reappeared after 2 to 8 weeks, in spite of maintena...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1976.tb01829.x
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Perforating granuloma annulare (PGA) is considered an histologic subtype of granuloma annulare (GA) and it is described as a very rare disease, usually of children, affecting the dorsum of the hands. Mechanisms leading to perforation are unknown. Our experience suggested a different clinical presentation, so...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-4362.1997.00047.x
更新日期:1997-05-01 00:00:00
abstract::Asiaticoside, isolated from Centella asiatica, promotes fibroblast proliferation and extracullar matrix synthesis in wound healing. The precise mechanism, however, in molecular and gene expression levels still remains partially understood. Using cDNA microarray technology, the alternation of genes expression profiles ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02047.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Mycosis fungoides has numerous clinical presentations. METHODS:We present two cases in which mycosis fungoides clinically mimicked reticular erythematous mucinosis. RESULTS:Both patients had extracutaneous involvement. One had a fatal outcome. CONCLUSIONS:We suggest that full systemic evaluation be perfor...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02434.x
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Pemphigus vegetans, a variant of pemphigus vulgaris, constitutes a rare form of all pemphigus cases, and oral involvement is common. Two clinical subtypes of pemphigus vegetans exist, characterized initially by flaccid bullae and erosions (Neumann) or pustules (Hallopeau). Both subtypes subsequently develop ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02480.x
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION:Even though androgenetic alopecia (AGA) is the most common type of alopecia, factors associated with AGA severity have been poorly investigated. OBJECTIVES:The objective of our study was to investigate risk factors for AGA severity among a Caucasian population. METHODS:A cross-sectional study was conduct...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13652
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. AIM:To determine the characteristic clinical and histopa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04164.x
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Most treatment protocols for vitiligo usually do not result in complete repigmentation. Therefore, cosmetically acceptable camouflage, low cost and easy to handle alternatives are warranted. OBJECTIVE:To evaluate the efficacy of low-cost self-tanner available in the Thai market in normal subjects with skin ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03356.x
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:The use of lasers is very common in dermatology; however, many patients fear it and have various misconceptions about it. A literature search failed to show any studies on this topic. OBJECTIVE:To explore the various misconceptions of patients about lasers in dermatology. METHODS:A self-administered questi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05028.x
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:This study sought to gain a better understanding of the patient population in Kampala and was further designed to elucidate barriers that may delay individuals from receiving proper dermatologic care. METHODS:The study took place at the dermatovenereology clinic of a tertiary care hospital in Kampala. New a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13435
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Potent teratogenicity limits the use of isotretinoin among females of childbearing potential (FCBP). OBJECTIVE:To explore the current practice of dermatologists for pregnancy prevention when prescribing isotretinoin for FCBP. MATERIALS AND METHODS:A self-administered questionnaire was distributed to 160 de...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.04875.x
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short-term results, but longer follow-up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six months of follow-up. METHODS...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12729
更新日期:2015-01-01 00:00:00