Abstract:
OBJECTIVE:To report the results from a retrospective chart review looking at the combination of linezolid and serotonergic antidepressants and to report two cases of serotonin syndrome which were identified at our hospital. CASE SUMMARY:During the retrospective chart review one case of serotonin syndrome was identified. A 65-year-old female was receiving escitalopram for the treatment of depression prior to admission. Linezolid therapy was initiated on admission and two days later the patient had a tonic-clonic seizure. Escitalopram was discontinued and the patient did not have any further seizure activity. In a second case, a 37-year-old male was receiving citalopram during hospitalization and was started on concomitant linezolid. The patient had myoclonus and was observed to be tremulous throughout therapy with linezolid. Ten days after discontinuation of linezolid the patient continued to have symptoms until the withdrawal of citalopram. The Naranjo probability scale scores the first case as possibly related and the second case as probably related to the combination. DISCUSSION:It has been well documented in the literature that the combination of linezolid and serotonergic antidepressants may cause serotonin syndrome. In this retrospective chart review only one patient of 53 (1.8%) had symptoms highly suggestive of serotonin syndrome. A second patient continued to have symptoms of serotonin syndrome even after withdrawal of linezolid. CONCLUSIONS:This retrospective review and subsequent case reports confirm the rare, but serious, potential of serotonin syndrome associated with the combination of linezolid and serotonergic antidepressants.
journal_name
Int J Psychiatry Medjournal_title
International journal of psychiatry in medicineauthors
Lorenz RA,Vandenberg AM,Canepa EAdoi
10.2190/PM.38.1.hsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
81-90issue
1eissn
0091-2174issn
1541-3527journal_volume
38pub_type
杂志文章abstract:OBJECTIVE:No systematic information exists on what U.S. medical schools are teaching on spirituality and health or on the attitudes of faculty toward inclusion of this subject in the medical curriculum. We systematically surveyed U.S. medical school deans and assessed both attitudes about and the extent to which spirit...
journal_title:International journal of psychiatry in medicine
pub_type: 杂志文章
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journal_title:International journal of psychiatry in medicine
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journal_title:International journal of psychiatry in medicine
pub_type: 杂志文章
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journal_title:International journal of psychiatry in medicine
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journal_title:International journal of psychiatry in medicine
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