Abstract:
PURPOSE:To develop and evaluate a method based on ultrashort echo-time radial magnetic resonance (MR) imaging to quantify bone water (BW) concentration as a new metric of bone quality in human cortical bone in vivo. MATERIALS AND METHODS:Human subject studies were institutional review board approved and HIPAA compliant; informed consent was obtained. Cortical BW concentration was determined with custom-designed MR imaging sequences at 3.0 T and was validated in sheep and human cortical bone by using exchange of native water with deuterium oxide (D(2)O). The submillisecond T2* of BW requires correction for relaxation losses during the radiofrequency pulse. BW was measured at the tibial midshaft in healthy pre- and postmenopausal women (mean age, 34.6 and 69.4 years, respectively; n = 5 in each group) and in patients receiving maintenance hemodialysis (mean age, 51.8 years; n = 6) and was compared with bone mineral density (BMD) at the same site at peripheral quantitative computed tomography, as well as with BMD of the lumbar spine and hip at dual x-ray absorptiometry. Data were analyzed by using the Pearson correlation coefficient and two-sided t tests as appropriate. RESULTS:Excellent agreement was obtained ex vivo between the water displaced by using D(2)O exchange and water measured with respect to a reference sample (r(2) = 0.99, P < .001). In vivo, BW in the postmenopausal group was greater by 65% (28.7% +/- 1.3 [standard deviation] vs 17.4% +/- 2.2, P < .001) than in the premenopausal group, and patients with renal osteodystrophy had higher BW (41.4% +/- 9.6) than the premenopausal group by 135% (P < .001) and the postmenopausal group by 43% (P = .02). BMD showed an opposite behavior, with much smaller group differences. Because the majority of BW is in the pore system of cortical bone, this parameter provides a surrogate measure for cortical porosity. CONCLUSION:A new MR imaging-based method for quantifying BW noninvasively has been demonstrated.
journal_name
Radiologyjournal_title
Radiologyauthors
Techawiboonwong A,Song HK,Leonard MB,Wehrli FWdoi
10.1148/radiol.2482071995subject
Has Abstractpub_date
2008-09-01 00:00:00pages
824-33issue
3eissn
0033-8419issn
1527-1315pii
2482071995journal_volume
248pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Nephrocalcinosis was diagnosed by means of gray-scale somography in a premature infant with severe bronchopulmonary dysplasia. The examination provided a way of localizing faint calcifications seen on a plain abdominal radiograph. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/128.2.459
更新日期:1978-08-01 00:00:00
abstract:PURPOSE:To evaluate the prevalence of testicular microlithiasis (TM) in children who have undergone scrotal ultrasonography (US) and their association with testicular tumors. MATERIALS AND METHODS:This HIPAA-compliant study with waiver of informed consent was approved by the institutional review board. From 2003 to 20...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.13130394
更新日期:2014-03-01 00:00:00
abstract::Sensitivity and specificity of first screen mammography in a randomized screening trial at five centers are reported. A total of 23,101 women underwent mammography; in 139, breast cancer was detected at first screening; in 20, less than 12 months after first screening; and in 47, at second screening. All 206 cancer ca...
journal_title:Radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1148/radiology.160.2.3523590
更新日期:1986-08-01 00:00:00
abstract::Background MRI with hepatobiliary contrast material is more sensitive than MRI with extracellular contrast material in the detection of hepatocellular carcinoma (HCC). Purpose To determine whether postsurgical outcomes differ between patients who undergo MRI with hepatobiliary contrast material and those who undergo M...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2019190414
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To evaluate the cochlear modiolus with thin-section magnetic resonance (MR) imaging in healthy subjects and patients with a large endolymphatic duct and sac, and to assess whether the cochlea is normal or abnormal in patients with a large endolymphatic duct and sac. MATERIALS AND METHODS:MR images were obtaine...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.213.3.r99dc05819
更新日期:1999-12-01 00:00:00
abstract::A prospective study was undertaken to establish the normal spectrum and timing of gadolinium-enhanced magnetic resonance (MR) imaging findings in 15 patients who had resolution of symptoms after successful lumbar disk surgery. Enhancement of the facet joints (in 88% of disk levels) and paraspinal muscles (100%) decrea...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.182.1.1727310
更新日期:1992-01-01 00:00:00
abstract::Alterations in gastric physiology caused by selective embolization and vasopressin infusion of the left gastric artery were evaluated in 29 dogs. Gastric acidity was not significantly altered following Gelfoam embolization but decreased sharply with vasopressin infusion. These results suggest that the segmental occlus...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/120.3.533
更新日期:1976-09-01 00:00:00
abstract::BackgroundThe performance of PET/MRI in the determination of distant metastases (M stage) in rectal cancer relative to the current practice with contrast material-enhanced CT is largely unknown.PurposeTo compare the staging of clinical M stage rectal cancer with fluorine 18 fluorodeoxyglucose (FDG) PET/MRI (including ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2019190794
更新日期:2020-02-01 00:00:00
abstract::The effects of magnetic resonance (MR) pulse sequences and timing parameters on tumor-liver contrast were studied in an animal model of metastatic liver cancer. Six spin-echo (SE), three inversion-recovery (IR), and four gradient-echo (GRE) sequences were evaluated at 0.6 T before and after injection of super-paramagn...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.172.2.2748820
更新日期:1989-08-01 00:00:00
abstract:PURPOSE:To determine whether perfusion-weighted and proton spectroscopic MR imaging can be used to differentiate high-grade primary gliomas and solitary metastases on the basis of differences in vascularity and metabolite levels in the peritumoral region. MATERIALS AND METHODS:Fifty-one patients with a solitary brain ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2223010558
更新日期:2002-03-01 00:00:00
abstract::A previously healthy man had a carcinoid tumor that caused obstruction and dilatation of the appendiceal lumen, with subsequent inflammation of the appendix. He had acute pain in the lower right abdomen, loss of appetite, constipation, pyrexia, and an increased erythrocyte sedimentation rate without leukocytosis. Alth...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.188.1.8511320
更新日期:1993-07-01 00:00:00
abstract:PURPOSE:To evaluate differences in T2 values in femoral and tibial cartilage at magnetic resonance (MR) imaging in patients with varying degrees of osteoarthritis (OA) compared with healthy subjects and to develop a mapping and display method based on calculation of T2 z scores for visual grading and assessment of cart...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2322030976
更新日期:2004-08-01 00:00:00
abstract::Purpose To determine if the allergic-like breakthrough reaction rate of intravenous corticosteroid prophylaxis administered 5 hours before contrast material-enhanced computed tomography (CT) is noninferior to that of a traditional 13-hour oral regimen. Materials and Methods Institutional review board approval was obta...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017170107
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To investigate whether ultrasonographic (US) features of thyroid nodules are associated with tumor recurrence in classic papillary thyroid carcinoma (PTC). MATERIALS AND METHODS:This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. A total ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2015142470
更新日期:2015-11-01 00:00:00
abstract::The American College of Radiology's Commission on Nuclear Magnetic Resonance has recommended adoption of the term "Magnetic Resonance" as a replacement. The author offers background and rationale for this shift in terminology. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.150.1.6689780
更新日期:1984-01-01 00:00:00
abstract::Multicenter, collaborative studies offer an effective way to meet the growing need for timely and generalizable clinical evaluations of imaging technologies. This article discusses issues of study design, statistical analysis, organization, and day-to-day group operation for collaborative prospective clinical evaluati...
journal_title:Radiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1148/radiology.175.2.2183290
更新日期:1990-05-01 00:00:00
abstract:PURPOSE:To assess syringe use among neuroangiographers and evaluate air emboli produced with glass and plastic syringes. MATERIALS AND METHODS:Questionnaires on syringes use were sent to 100 members of the American Society of Neuroradiology (ASNR). An in vitro system counted emboli during injections of contrast materi...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.191.3.8184070
更新日期:1994-06-01 00:00:00
abstract::An unusually prominent soleal line (a normal anatomic variant) may mimic periosteal reaction along the posterior margin of the proximal tibial shaft. This area of pseudoperiostitis is differentiated from hyperostoses arising from the anterior tibial tubercle and the interosseous membrane. It is always associated with ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/119.1.79
更新日期:1976-04-01 00:00:00
abstract:PURPOSE:To comply with federal and state guidelines, a credentialing process was developed for nonradiologist medical users of fluoroscopy. MATERIALS AND METHODS:Seventy-three nonradiologist physicians participated in a program consisting of (a) an introductory 1-hour lecture; (b) a 10-page booklet providing basic inf...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.190.1.8259420
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To compare the image quality and degree of vessel narrowing at flow-sensitive dephasing (FSD) magnetic resonance (MR) angiography of the hands with those at contrast material-enhanced MR angiography of the hands in patients with systemic sclerosis. MATERIALS AND METHODS:In a single-center study with institutio...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10100851
更新日期:2011-04-01 00:00:00
abstract::Background Patients with wrist trauma and negative findings on radiographs often undergo additional MRI examinations to assess for radiographically occult fractures. Dual-energy CT may be more readily available than MRI in some settings. Purpose To evaluate the diagnostic test accuracy of dual-energy CT in helping det...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2020192701
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To prospectively evaluate the accuracy of using physical examination to identify puncture-related groin pseudoaneurysms, as assessed by using duplex ultrasonography (US), after percutaneous transluminal procedures and to prospectively evaluate the association between preinterventional platelet count, antiplatel...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2402050907
更新日期:2006-08-01 00:00:00
abstract::Normal kidney length was measured on the excretory urogram in 262 children 0 to 14.5 years of age (422 kidneys). While mean values were similar to those in the literature, the standard deviation (0.785 cm) was much lower than that reported previously. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.150.3.6695070
更新日期:1984-03-01 00:00:00
abstract:PURPOSE:To assess the diagnostic performance of various Doppler ultrasonographic (US) vascularity measures in conjunction with grayscale (GS) criteria in differentiating benign from malignant breast masses, by using histologic findings as the reference standard. MATERIALS AND METHODS:Institutional Review Board and HIP...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2492060888
更新日期:2008-11-01 00:00:00
abstract::The diagnostic value of computed tomography (CT) and barium enema (BE) studies was evaluated prospectively in hospitalized patients with the presumptive diagnosis of acute sigmoid diverticulitis based on the presence of left-lower-quadrant pain and tenderness, fever, and leukocytosis. Of 56 patients, 11 had sigmoid di...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.176.1.2191360
更新日期:1990-07-01 00:00:00
abstract::Three patients presented with meningitis associated with congenital defects of the inner ear, consisting of a cyst-like cochlea and a short, wide horizontal semicircular canal. The findings were easily identified on routine skull radiographs, alleviating the need for further studies and leading to treatment of the def...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.135.2.7367630
更新日期:1980-05-01 00:00:00
abstract::Radiolabeling of Ivalon (polyvinyl alcohol sponge) particles permits localization of injected particles during embolization through the use of a portable gamma camera and provides a means to prevent potentially fatal complications such as pulmonary embolization. A more efficient technique of labeling Ivalon particles ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.177.2.2217800
更新日期:1990-11-01 00:00:00
abstract::Background Supine or prone positioning of the patient on the gantry table is the current standard of care for CT-guided lung biopsy; positioning biopsy side down was hypothesized to be associated with lower pneumothorax rate. Purpose To assess the effect of positioning patients biopsy side down during CT-guided lung b...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2019182321
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate the magnetic resonance (MR) imaging features of the developing femur in fetal pig specimens. MATERIALS AND METHODS:MR images of 15 fetal pig femurs, which were categorized into three groups of specimens representing each third of the gestational period, were used to compare increasing femoral lengt...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2332030131
更新日期:2004-11-01 00:00:00
abstract::A double-blind, randomized study was conducted in 170 patients to compare the effects of two hypertonic contrast media in phlebography of the leg: one was ionic [methylglucamine metrizoate (Isopaque Cerebral, 280 mg I/mI)] and the other nonionic [metrizamide (Amipaque, 280 mg I/mI)]. Ninety patients who showed no veno...
journal_title:Radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1148/radiology.140.3.7025090
更新日期:1981-09-01 00:00:00