Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase.

Abstract:

:A murine monoclonal antibody, H317, specific for placental-type alkaline phosphatase was labelled with 123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1-4 years after removal of the primary tumour. Four patterns of distribution were visible: (1) normal uptake; (2) focal accumulation; (3) diffuse uptake; and (4) 'cold' areas. Six patients, five of whom were clinically negative for ovarian cancer, had normal scans; 11 patients, eight of whom were clinically positive, had increased uptake. One patient had visibly 'cold' areas. Findings were confirmed, where possible, at surgery.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Critchley M,Brownless S,Patten M,McLaughlin PJ,Tromans PM,McDicken IW,Johnson PM

doi

10.1016/s0009-9260(86)80373-7

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

107-12

issue

2

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(86)80373-7

journal_volume

37

pub_type

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