Spongiform encephalopathy in a patient with acquired immune deficiency syndrome (AIDS).

abstract：:The present study used cocultures of rat dorsal root ganglia (DRG) and peritoneal macrophages to define the role of activated complement components during demyelination. The complement cascade was activated in vitro by treatment of the cultures with natural rat serum and lipopolysaccharides. Complement activation was ...

journal_title：Acta neuropathologica

authors： Brück W,Brück Y,Diederich U,Piddlesden SJ

更新日期：1995-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the translational product...

journal_title：Acta neuropathologica

authors： Blokhuis AM,Groen EJ,Koppers M,van den Berg LH,Pasterkamp RJ

更新日期：2013-06-01 00:00:00

abstract：:In 54 cats experimental brain tumors were produced by xenotransplantation of the blastomatous glial cell clone RG2 into the internal capsule of the left hemisphere. Fifteen of these animals were treated with dexamethasone for 1 week and four animals for 2 h. The occurrence of glial fibrillary acidic (GFA) protein in t...

journal_title：Acta neuropathologica

authors： Szymas J,Hossmann KA

更新日期：1984-01-01 00:00:00

abstract：:Chronic traumatic encephalopathy (CTE) is a progressive degenerative disorder associated with repetitive traumatic brain injury. One of the primary defining neuropathological lesions in CTE, based on the first consensus conference, is the accumulation of hyperphosphorylated tau in gray matter sulcal depths. Post-morte...

journal_title：Acta neuropathologica

authors： Holleran L,Kim JH,Gangolli M,Stein T,Alvarez V,McKee A,Brody DL

更新日期：2017-03-01 00:00:00

abstract：:Autopsy findings of a patient, with sialidosis type I phenotype carrying V217M/G243R mutations in the lysosomal sialidase gene and biochemically defined isolated sialidase deficiency, who died of intractable lymphoma at the age of 32 years, are described. Perikaryal expansion of cytoplasm was evident, mostly in motor ...

journal_title：Acta neuropathologica

authors： Uchihara T,Ohashi K,Kitagawa M,Kurata M,Nakamura A,Hirokawa K,Kasuga T,Kobayashi T

更新日期：2010-01-01 00:00:00

abstract：:Numbers of synapses were counted in columns of neuropil orientated at right angles to the pia in frontal and temporal regions from postmortem brains. In the frontal region of 28 patients aged 26-90 years there were 1.2 X 10(8) mm3 (SD 0.03 X 10(8], and in the temporal of 18 patients aged 16-90 years there were 1.4 X 1...

journal_title：Acta neuropathologica

authors： Gibson PH

更新日期：1983-01-01 00:00:00

abstract：:We report two sporadic cases of tauopathy with unusual neuropathological features. The ages of the patients at death were 86 and 74 years, and the disease durations were 4 and 3 years, respectively. The former patient showed progressive dementia and amyotrophy (autopsy revealed that severe cervical spondylosis was res...

journal_title：Acta neuropathologica

authors： Sakai K,Piao YS,Kikugawa K,Ohara S,Hasegawa M,Takano H,Fukase M,Nishizawa M,Kakita A,Takahashi H

更新日期：2006-09-01 00:00:00

abstract：:A 48-year-old man with dural arteriovenous malformation (AVM) is reported. Radiologically, the dural AVM was demonstrated mainly in the region of the left transverse sinus. Postmortem examination revealed dural AVM involving the bilateral transverse, superior sagittal and straight sinuses. In addition, numerous malfor...

journal_title：Acta neuropathologica

authors： Hinokuma K,Ohama E,Ikuta F,Tanimura K,Kameyama S

更新日期：1990-01-01 00:00:00

abstract：:DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-function DICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation...

journal_title：Acta neuropathologica

authors： de Kock L,Priest JR,Foulkes WD,Alexandrescu S

更新日期：2020-04-01 00:00:00

abstract：:The close correlation between abnormally low pre-mortem cerebrospinal fluid (CSF) concentrations of amyloid-β1-42 (Aβ(1-42)) and plaque burden measured by amyloid imaging as well as between pathologically increased levels of CSF tau and the extent of neurodegeneration measured by MRI has led to growing interest in usi...

journal_title：Acta neuropathologica

authors： Shaw LM,Vanderstichele H,Knapik-Czajka M,Figurski M,Coart E,Blennow K,Soares H,Simon AJ,Lewczuk P,Dean RA,Siemers E,Potter W,Lee VM,Trojanowski JQ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2011-05-01 00:00:00

abstract：:The binding patterns of lectins to normal peripheral nerves were examined. Twelve biotinylated lectins were used in this study; Canavalia ensiformis (Con A), Pisum sativum (PSA), Lens culinaris (LCA), Ricinus communis 1 (RCA-1), Arachis hypogaea (PNA), Glycine max (SBA), Sophora japonica (SJA), Bandeiraea simplicifoli...

journal_title：Acta neuropathologica

authors： Matsumura K,Nakasu S,Nioka H,Handa J

更新日期：1993-01-01 00:00:00

abstract：:The amyloid cascade hypothesis of Alzheimer's disease (AD) is testable: it implies that interference with Abeta aggregation and plaque formation may be therapeutically useful. Abeta42 immunisation of amyloid precursor protein (APP) transgenic mice prevented plaque formation and caused removal of existing plaques. The ...

journal_title：Acta neuropathologica

authors： Boche D,Denham N,Holmes C,Nicoll JA

更新日期：2010-09-01 00:00:00

abstract：:A neuropathological study is presented of a case showing the association of tuberous sclerosis of the brain and dysplasia of the corpus callosum as well as omphalocele and malrotated colon. No signs of tuberous sclerosis were found in the internal organs. From a review of the literature this appears to be the fourth c...

journal_title：Acta neuropathologica

authors： Barth PG,Stam FC,von der Harten JJ

更新日期：1978-04-26 00:00:00

abstract：:Histomorphological and histochemical variability was studied in muscle specimens from 30 patients with congenital muscular dystrophy (CMD). We found involvement of the central nervous system in 8 patients (Fukuyama CMD, F-CMD), involvement of the brain and the eyes in 5 patients (muscle, eye and brain disease, MEB-D) ...

journal_title：Acta neuropathologica

authors： Leyten QH,ter Laak HJ,Gabreëls FJ,Renier WO,Renkawek K,Sengers RC

更新日期：1993-01-01 00:00:00

abstract：:Skeins or skein-like inclusions, one of the two types of ubiquitinated intraneuronal inclusions in amyotrophic lateral sclerosis (ALS), in the neostriatum are not specific to the disease, but it has not yet been determined whether the other, spherical or crescent-shaped inclusions (SCI) are pathognomonic. To clarify t...

journal_title：Acta neuropathologica

authors： Kawashima T,Doh-ura K,Kikuchi H,Iwaki T

更新日期：2001-11-01 00:00:00

abstract：:The expression of members of the Jun family of transcription factors was examined by immunohistochemistry, Western blotting, in situ hybridization and Northern blotting in the developing and adult rat brain following colchicine administration. Apoptotic cells, as revealed by their typical morphology and positive stain...

journal_title：Acta neuropathologica

authors： Pozas E,Aguado F,Ferrer I

更新日期：1999-08-01 00:00:00

abstract：:Two cases of Central neurocytoma arising in the lateral ventricles are presented. Both patients had well-circumscribed masses in the right lateral ventricle causing hydrocephalus. The tumors were composed of small round cells forming Homer Wright rosettes against a fine fibrillary background. In one patient surgical r...

journal_title：Acta neuropathologica

authors： Townsend JJ,Seaman JP

更新日期：1986-01-01 00:00:00

abstract：:A series of 50 human primary intracranial tumors were cultivated in vitro in an attempt to establish cell lines with the trypsinization technique. During the in vitro adaptation period, cultures were maintained at high cell density to avoid rapid over-growth by connective tissue. Five lines were established from 5 tum...

journal_title：Acta neuropathologica

authors： Maunoury R

更新日期：1977-07-15 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is an inherited neuromuscular disease caused by expansion of a polyglutamine (polyQ) tract in the androgen receptor (AR). SBMA is triggered by the interaction between polyQ-AR and its natural ligands, testosterone and dihydrotestosterone (DHT). SBMA is characterized by the los...

journal_title：Acta neuropathologica

authors： Malena A,Pennuto M,Tezze C,Querin G,D'Ascenzo C,Silani V,Cenacchi G,Scaramozza A,Romito S,Morandi L,Pegoraro E,Russell AP,Sorarù G,Vergani L

更新日期：2013-07-01 00:00:00

abstract：:Mutations in the fused in sarcoma (FUS) gene are linked to a form of familial amyotrophic lateral sclerosis (ALS), ALS6. The FUS protein is a major component of the ubiquitin-positive neuronal cytoplasmic inclusions in both ALS6 and some rare forms of frontotemporal lobar degeneration (FTLD). The latter are now collec...

journal_title：Acta neuropathologica

authors： Aoki N,Higashi S,Kawakami I,Kobayashi Z,Hosokawa M,Katsuse O,Togo T,Hirayasu Y,Akiyama H

更新日期：2012-09-01 00:00:00

abstract：:Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD is even considered to be a pre-NFT stage in the disease process of AD. Currently, the composition of GVD bodies, the mechanisms associated ...

journal_title：Acta neuropathologica

authors： Hondius DC,Koopmans F,Leistner C,Pita-Illobre D,Peferoen-Baert RM,Marbus F,Paliukhovich I,Li KW,Rozemuller AJM,Hoozemans JJM,Smit AB

更新日期：2021-01-25 00:00:00

abstract：:We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient wit...

journal_title：Acta neuropathologica

authors： Crain BJ,McPhatter L,Croom DW 2nd,Hulette CM

更新日期：1995-01-01 00:00:00

abstract：:We describe features of a patient that broadens the clinical and pathological spectrum of neurofilament inclusion disease (NFID). The patient was a 52-year-old man with a 5--6 year history of progressive, asymmetrical spastic weakness of the upper and lower extremities; L-DOPA-unresponsive parkinsonism; and SPECT evid...

journal_title：Acta neuropathologica

authors： Josephs KA,Uchikado H,McComb RD,Bashir R,Wszolek Z,Swanson J,Matsumoto J,Shaw G,Dickson DW

更新日期：2005-04-01 00:00:00

abstract：:The relationship between diabetes and the size, density and area of the ventromedial hypothalamic nucleus (VMH) was studied in the genetically diabetic Chinese hamster. Matched diabetic and non-diabetic control chinese hamsters were perfused, the hypothalamus collected, sectioned and stained for light microscopy. The ...

journal_title：Acta neuropathologica

authors： Garris DR,Diani AR,Smith C,Gerritsen GC

更新日期：1982-01-01 00:00:00

abstract：:The extent of DNA fragmentation analysed using the TUNEL technique was evaluated in post-mortem human brain tissue. Twenty-four patients with clinical and histopathological diagnosis of Alzheimer's disease (AD) and a short post-mortem delay were analysed. We report an increase in the count of TUNEL-labelled cells as t...

journal_title：Acta neuropathologica

authors： Overmyer M,Kraszpulski M,Helisalmi S,Soininen H,Alafuzoff I

更新日期：2000-12-01 00:00:00

abstract：:Six subtypes of sporadic Creutzfeldt-Jakob disease with distinctive clinico-pathological features have been identified largely based on two types of the abnormal prion protein, PrP(Sc), and the methionine (M)/valine (V) polymorphic codon 129 of the prion protein. The existence of affected subjects showing mixed phenot...

journal_title：Acta neuropathologica

authors： Parchi P,Strammiello R,Notari S,Giese A,Langeveld JP,Ladogana A,Zerr I,Roncaroli F,Cras P,Ghetti B,Pocchiari M,Kretzschmar H,Capellari S

更新日期：2009-11-01 00:00:00

abstract：:There is evidence that apoptotic cell death mechanisms contribute to muscle fibre loss in dystrophinopathies, but little knowledge about the activators of the final degrading caspase cascade in muscle fibre apoptosis. As mitochondria-related activation of this caspase cascade, through e.g. APAF-1, could not be proven ...

journal_title：Acta neuropathologica

authors： Tews DS

更新日期：2005-02-01 00:00:00

abstract：:Vascular smooth muscle cells are involved in deposition of amyloid in brain blood vessels. Accumulation of amyloid-beta peptide (Abeta) in cultured brain vascular smooth muscle cells that overexpress human amyloid-beta precursor protein (APP) Swedish, is strongly enhanced by exposure to iron ions. We studied cellular ...

journal_title：Acta neuropathologica

authors： Frackowiak J,Potempska A,Mazur-Kolecka B

更新日期：2009-05-01 00:00:00

abstract：:Inflammatory processes have been implicated in the formation of senile plaques in the cerebral cortex of patients with dementia of the Alzheimer type (DAT), since several inflammation-induced proteins are present within these plaques. The relation between inflammatory components and other amyloid beta protein (A beta)...

journal_title：Acta neuropathologica

authors： Verbeek MM,Otte-Höller I,Wesseling P,Ruiter DJ,de Waal RM

更新日期：1996-01-01 00:00:00

abstract：:To investigate the pathogenetic role of human T lymphocyte virus type I (HTLV-I) in central nervous system disease, a rat model for HTLV-I-associated myelopathy/tropical spastic paraparesis, designated as HAM rat disease, has been established. Wistar-King-Aptekman-Hokudai strain rats with induced HTLV-I infection deve...

journal_title：Acta neuropathologica

authors： Kasai T,Ikeda H,Tomaru U,Yamashita I,Ohya O,Morita K,Wakisaka A,Matsuoka E,Moritoyo T,Hashimoto K,Higuchi I,Izumo S,Osame M,Yoshiki T

更新日期：1999-02-01 00:00:00