High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.

abstract：:Menadione (2-methyl-1,4-naphthoquinone, a redox cycling and arylating quinone; 5-100 microM) inhibited the canalicular vacuolar accumulation (CVA) of a fluorescent bile acid, cholyl-lysyl-fluorescein (CLF), in rat hepatocyte couplets. This was associated with depletion of reduced glutathione and accumulation of oxidiz...

journal_title：Toxicology and applied pharmacology

authors： Stone V,Coleman R,Chipman JK

更新日期：1996-06-01 00:00:00

abstract：:The objective of this study is to elucidate the role of cytochrome P450 2E1 in the metabolic activation of acetaminophen (APAP) in mouse kidneys. With the kidney microsomes from C3H/HeJ mice, a significant sex-related difference was observed in the NADPH-dependent formation of a reactive APAP metabolite which was trap...

journal_title：Toxicology and applied pharmacology

authors： Hu JJ,Lee MJ,Vapiwala M,Reuhl K,Thomas PE,Yang CS

更新日期：1993-09-01 00:00:00

abstract：:This paper reviews the occurrence and properties of cyanobacterial toxins, with reference to the recognition and management of the human health risks which they may present. Mass populations of toxin-producing cyanobacteria in natural and controlled waterbodies include blooms and scums of planktonic species, and mats ...

journal_title：Toxicology and applied pharmacology

authors： Codd GA,Morrison LF,Metcalf JS

更新日期：2005-03-15 00:00:00

abstract：:Inhaling concomitants from Asian sand dust (ASD) may result in exacerbation of pneumonia by the pathogen. The exacerbating effect of ASD on pneumonia induced by Klebsiella pneumoniae (KP) was investigated in ICR mice. The organic substances adsorbed onto ASD collected from the atmosphere of Iki-island in Japan were ex...

journal_title：Toxicology and applied pharmacology

authors： He M,Ichinose T,Yoshida S,Yamamoto S,Inoue K,Takano H,Yanagisawa R,Nishikawa M,Mori I,Sun G,Shibamoto T

更新日期：2012-01-15 00:00:00

abstract：:Many studies of nanomaterials make non-systematic alterations of nanoparticle physicochemical properties. Given the immense size of the property space for nanomaterials, such approaches are not very useful in elucidating fundamental relationships between inherent physicochemical properties of these materials and their...

journal_title：Toxicology and applied pharmacology

authors： Bai X,Liu F,Liu Y,Li C,Wang S,Zhou H,Wang W,Zhu H,Winkler DA,Yan B

更新日期：2017-05-15 00:00:00

abstract：:Diurnal patterns of eating, drinking, locomotor activity, and rearing in male Fischer-344 rats were examined for 11 days after a single oral dose of triethyltin bromide (TET) at 0, 1.5, 3, or 5 mg/kg. The 5 mg/kg group exhibited a time-related drop in food consumption and body weight until 3 of 10 rats were sacrificed...

journal_title：Toxicology and applied pharmacology

authors： Bushnell PJ,Evans HL

更新日期：1986-09-30 00:00:00

abstract：:Trimethyltin (TMT), is a hippocampal neurotoxicant characterized by neuronal degeneration, astrogliosis, and microglia reactivity with an associated elevation in proinflammatory cytokine mRNA levels. To examine the role of proinflammatory cytokines in the TMT-induced glia response, mixed cortical glia cultures were ex...

journal_title：Toxicology and applied pharmacology

authors： Harry GJ,Tyler K,d'Hellencourt CL,Tilson HA,Maier WE

更新日期：2002-05-01 00:00:00

abstract：:Environmental exposure to polychlorinated biphenyls (PCBs) is associated with an increased risk of incidence of metabolic disease, however the molecular mechanisms underlying this phenomenon are not fully understood. Our study provides new insights into molecular interactions between PCBs and retinoids (vitamin A and ...

journal_title：Toxicology and applied pharmacology

authors： Shmarakov IO,Lee YJ,Jiang H,Blaner WS

更新日期：2019-10-15 00:00:00

abstract：:This pilot study was designed to assess whether a synthetic matrix metalloproteinase (MMP) inhibitor has anti-inflammatory properties in mild asthma. Tumor necrosis factor alpha (TNFalpha) has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses, and its release can be i...

journal_title：Toxicology and applied pharmacology

authors： Bruce C,Thomas PS

更新日期：2005-06-01 00:00:00

abstract：:Arsenic is an environmental toxicant that reduces the lifespan of circulating erythrocytes during chronic exposure. Our previous studies had indicated involvement of hypercholesterolemia and reactive oxygen species (ROS) in arsenic-induced apoptotic death of erythrocytes. In this study, we have shown an effective reco...

journal_title：Toxicology and applied pharmacology

authors： Biswas D,Sen G,Sarkar A,Biswas T

更新日期：2011-01-01 00:00:00

abstract：:Previous experiments showed that treatment of mice and rats with thioacetamide (TAA) induced liver cell damage, fibrosis and/or cirrhosis, associated with increased oxidative stress and activation of hepatic stellate cells. Some experiments suggest that CYP2E1 may be involved in the metabolic activation of TAA. Howeve...

journal_title：Toxicology and applied pharmacology

authors： Kang JS,Wanibuchi H,Morimura K,Wongpoomchai R,Chusiri Y,Gonzalez FJ,Fukushima S

更新日期：2008-05-01 00:00:00

abstract：:Besides pathology endpoints, additional immune function endpoints have been included in the Note for Guidance on Repeated Dose Toxicity by the European Union (July 2001), which concern the analysis of antibody responses to a T-cell-dependent antigen. Guidance papers of other regulatory authorities are published as wel...

journal_title：Toxicology and applied pharmacology

authors： van der Laan JW,van Loveren H

更新日期：2005-09-01 00:00:00

abstract：:Antineoplastic drugs cause severe cytotoxicity for normal cells, especially hematopoietic stem cells (HSCs). However, bleomycin (BLM) is glycopeptide antibiotic that is effective on various cancers and has either low or no myelosuppression effects. The aim of the present study was to investigate the effect of BLM on 5...

journal_title：Toxicology and applied pharmacology

authors： Fakhrabadi HG,Rabbani-Chadegani A,Ghadam P,Amiri S

更新日期：2020-06-01 00:00:00

abstract：:A transformer cooled and insulated with a mixture of 65% Aroclor 1254 and 35% chlorinated benzenes located in the Binghamton State Office Building in Binghamton, New York, was involved in a fire, which produced soot containing polychlorinated biphenyls, biphenylenes, dioxins, and dibenzofurans. A single dose of either...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1983-03-15 00:00:00

abstract：:A quantitative method based upon a stochastic model was used to estimate rates of initiation (alteration to express the ATPase-deficient phenotype) and of clonal growth of altered cells in an initiation promotion experiment in the livers of female Wistar rats. Diethylnitrosamine (DEN) was used as the initiating agent ...

journal_title：Toxicology and applied pharmacology

authors： Moolgavkar SH,Luebeck EG,Buchmann A,Bock KW

更新日期：1996-05-01 00:00:00

abstract：:The pharmacokinetics of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) were measured in the beagle dog and rhesus monkey and compared with the kinetics observed in rats and humans. In addition, studies were conducted in anesthetized dogs to better understand the mechanism by which [14C]triclopyr is eliminated i...

journal_title：Toxicology and applied pharmacology

authors： Timchalk C,Nolan RJ

更新日期：1997-06-01 00:00:00

abstract：:Risk assessments are enhanced when policy and other decision-makers have access to experimental science designed to specifically inform key policy questions. Currently, our scientific understanding and science policy for environmental mixtures are based largely on extrapolating from and combining data in the observabl...

journal_title：Toxicology and applied pharmacology

authors： Mason AM,Borgert CJ,Bus JS,Moiz Mumtaz M,Simmons JE,Sipes IG,SOT Mixtures Task Force.

更新日期：2007-09-01 00:00:00

abstract：:Melatonin is a neuroendocrine hormone which is currently receiving considerable attention as a treatment for jet lag, a treatment for insomnia and, by some, a possible "magic bullet" for delaying the effects of aging and preventing cancer. Production of melatonin is focused primarily in the pineal gland with very wide...

journal_title：Toxicology and applied pharmacology

authors： Blumenthal GM,Kohn MC,Portier CJ

更新日期：1997-11-01 00:00:00

abstract：:To study the genotoxicity of valepotriates in vitro, the degree of DNA damage in human endothelial cell line ECV304 treated with 5-60 microg/mL of dichloromethane extracts of valerian (DEV) was analyzed by the Comet assay. No DNA damage was observed in ECV304 cells after culture for 48 h in the presence of 5,10, and 2...

journal_title：Toxicology and applied pharmacology

authors： Hui-lian W,Dong-fang Z,Zhao-feng L,Yang L,Qian-rong Li,Yu-zhen W

更新日期：2003-04-01 00:00:00

abstract：:In the present study we have examined the effects of hydrocarbons on the formation of reactive oxygen species (ROS) in human neutrophil granulocytes in vitro. We found that hydrocarbons induce ROS formation in a concentration-dependent manner and that the ROS-inducing potency increases with increasing number of carbon...

journal_title：Toxicology and applied pharmacology

authors： Dreiem A,Myhre O,Fonnum F

更新日期：2003-07-15 00:00:00

abstract：:Isoprene (2-methyl-1,3-butadiene), a volatile monomer occurring in the natural environment and used in the manufacture of elastomers, is a close chemical relative of the animal carcinogen 1,3-butadiene. To obtain toxicokinetic data for inhaled isoprene, male F344 rats were exposed in groups of 30 to 14C-labeled isopre...

journal_title：Toxicology and applied pharmacology

authors： Dahl AR,Birnbaum LS,Bond JA,Gervasi PG,Henderson RF

更新日期：1987-06-30 00:00:00

abstract：:A single 6-hr exposure to inhaled methanol (MeOH) has been shown to enhance carbon tetrachloride (CCl4) hepatotoxicity. The objective of the present study was to use gas uptake data and the development of a physiologically based pharmacokinetic model (PBPK) to determine in vivo changes in CCl4 metabolism resulting fro...

journal_title：Toxicology and applied pharmacology

authors： Evans MV,Simmons JE

更新日期：1996-10-01 00:00:00

abstract：:Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computer...

journal_title：Toxicology and applied pharmacology

authors： Emond C,Ruiz P,Mumtaz M

更新日期：2017-01-15 00:00:00

abstract：:Kidney is the primary target organ in chronic cadmium (Cd) toxicity, and oxidative stress plays an important role in this process. The nuclear transcription factor Nrf2 binds to antioxidant response elements (AREs) and regulates genes involved in protecting cells from oxidative damage. Whether kidney cells respond to ...

journal_title：Toxicology and applied pharmacology

authors： Chen J,Shaikh ZA

更新日期：2009-11-15 00:00:00

abstract：:Methyl bromide is used as a disinfectant to fumigate soil and a wide range of stored food commodities in warehouses and mills. Human exposure occurs during the manufacture and use of the chemical. The purpose of this investigation was to determine the disposition and metabolism of [14C]methyl bromide in rats after inh...

journal_title：Toxicology and applied pharmacology

authors： Bond JA,Dutcher JS,Medinsky MA,Henderson RF,Birnbaum LS

更新日期：1985-04-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (SCC) is responsible for approximately one-sixth of all cancer-related mortality worldwide. This malignancy has a multifactorial etiology involving several environmental, dietary and genetic factors. Since esophageal cancer has often metastasized at the time of diagnosis, current tre...

journal_title：Toxicology and applied pharmacology

authors： Stoner GD,Wang LS,Chen T

更新日期：2007-11-01 00:00:00

abstract：:After a fire involving a transformer, the State Office Building in Binghamton, New York, was contaminated with soot containing polychlorinated biphenyls, biphenylenes, naphthalenes, dioxins, and dibenzofurans. The toxicity of the soot and its effect on liver morphology after prolonged (subchronic) exposure were determ...

journal_title：Toxicology and applied pharmacology

authors： Turner JN,Collins DN

更新日期：1984-05-01 00:00:00

abstract：:This study sought to investigate the effects of environmentally relevant gestational followed by continued chronic exposure to the herbicide, atrazine, on motor function, cognition, and neurochemical indices of nigrostriatal dopamine (DA) activity in male rats. Dams were treated with 100 μg/kg atrazine, 10mg/kg atrazi...

journal_title：Toxicology and applied pharmacology

authors： Walters JL,Lansdell TA,Lookingland KJ,Baker LE

更新日期：2015-12-01 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are highly invasive and have a higher rate of distant metastasis. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in EGF/EGFR-mediated malignant progression and metastasis of TNBCs. Various studies have revealed that treatment with gallic acid down-regulates MMP-9 express...

journal_title：Toxicology and applied pharmacology

authors： Chen YJ,Lee YC,Huang CH,Chang LS

更新日期：2016-11-01 00:00:00

abstract：:Approaches for extrapolating in vitro toxicity testing results for prediction of human in vivo outcomes are needed. The purpose of this case study was to employ in vitro toxicokinetics and PBPK modeling to perform in vitro to in vivo extrapolation (IVIVE) of lindane neurotoxicity. Lindane cell and media concentrations...

journal_title：Toxicology and applied pharmacology

authors： Croom EL,Shafer TJ,Evans MV,Mundy WR,Eklund CR,Johnstone AF,Mack CM,Pegram RA

更新日期：2015-02-15 00:00:00