Two new neo-clerodane diterpenoids from Scutellaria barbata.

Abstract:

:Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C (1, named barbatin D) and 6-(2-acetoxy-3-methylbutanoloxy)-7-(2-carbonyl-3-methylbutanoyloxy) barbatin C (2, named barbatin E) were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1-2 showed cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 3.5-6.7 microM.

journal_name

J Integr Plant Biol

authors

Dai SJ,Shen L,Ren Y

doi

10.1111/j.1744-7909.2008.00672.x

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

699-702

issue

6

eissn

1672-9072

issn

1744-7909

pii

JIPB672

journal_volume

50

pub_type

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