Immune function of patients with gastrointestinal carcinoma after treatment with multiple infusions of monoclonal antibody 17.1A.

abstract：:Human epithelial cell lines derived from both carcinomatous and nomalignant tissues were characterized with respect to the presence and distribution of fibronectin by immunofluorescence microscopy. In cell lines derived from nonmalignant tissues or from primary carcinomas, fibronectin was found predominantly in an ext...

journal_title：Cancer research

authors： Smith HS,Riggs JL,Mosesson MW

更新日期：1979-10-01 00:00:00

abstract：:Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. APC and ras gene mutations have been shown to be important early molecular events in the development of colorectal neoplasms. The objective of this study w...

journal_title：Cancer research

authors： Smith AJ,Stern HS,Penner M,Hay K,Mitri A,Bapat BV,Gallinger S

更新日期：1994-11-01 00:00:00

abstract：:The tropism of breast cancer cells for bone and their tendency to induce an osteolytic phenotype are a result of interactions between breast cancer cells and stromal cells and are of paramount importance for bone metastasis. However, the underlying molecular mechanisms remain poorly understood. We hypothesize that tum...

journal_title：Cancer research

authors： Nannuru KC,Futakuchi M,Varney ML,Vincent TM,Marcusson EG,Singh RK

更新日期：2010-05-01 00:00:00

abstract：:The potential of transforming growth factor-alpha (TGF-alpha) to function as an autocrine growth factor was evaluated in numerous ovarian carcinoma cell lines. All 17 lines which were examined expressed the epidermal growth factor receptor and 16 cell lines, in addition, concomitantly secreted TGF-alpha. Radioimmunoas...

journal_title：Cancer research

authors： Stromberg K,Collins TJ 4th,Gordon AW,Jackson CL,Johnson GR

更新日期：1992-01-15 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00

abstract：:Protein synthesis is a vital cellular process that regulates growth and metabolism. It is controlled via signaling networks in response to environmental changes, including the presence of nutrients, mitogens, or starvation. The phosphorylation state of proteins involved in translation initiation is a limiting factor t...

journal_title：Cancer research

authors： Grzmil M,Hemmings BA

更新日期：2012-08-15 00:00:00

abstract：:The effects of N-5-dimethyl-9-(2-methoxy-4-methylsulfonylamino)-phenylamino-4- acridinecarboxamide (CI-921; NSC 343499), a lipophilic and water-soluble derivative of amsacrine (NSC 249992), on cell viability, growth, clonogenicity, and progression through the cell cycle were investigated in suspension cultures of Frie...

journal_title：Cancer research

authors： Traganos F,Bueti C,Darzynkiewicz Z,Melamed MR

更新日期：1987-01-15 00:00:00

abstract：:We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of human cancer. Such profiles would provide invaluable insight into mechanisms underlying the evolution of each tumor type and will provide molecular markers, which could radically improve cance...

journal_title：Cancer research

authors： Esteller M,Corn PG,Baylin SB,Herman JG

更新日期：2001-04-15 00:00:00

abstract：:Different cell growth effects were observed in MCF-7 cells after six daily exposures to either 17 beta-estradiol (E2), 2-hydroxyestradiol (2-OHE2), or 2-methoxyestradiol (2-MeOE2) at 10 nM levels. 2-OHE2 enhanced cell growth significantly (P < 0.05) more than did the parent compound, whereas 2-MeOE2 inhibited cell gro...

journal_title：Cancer research

authors： Lottering ML,Haag M,Seegers JC

更新日期：1992-11-01 00:00:00

abstract：:Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to control prostate cancer in most patients. Androgen-independent acquisit...

journal_title：Cancer research

authors： Cerasuolo M,Paris D,Iannotti FA,Melck D,Verde R,Mazzarella E,Motta A,Ligresti A

更新日期：2015-08-01 00:00:00

abstract：:Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors and cyclooxygenase-1 (COX-1) is now being reconsidered as a target for chemoprevention. Our aims were to determine whether selective COX-1 inhibition could delay or prevent cancer development a...

journal_title：Cancer research

authors： Li H,Zhu F,Chen H,Cheng KW,Zykova T,Oi N,Lubet RA,Bode AM,Wang M,Dong Z

更新日期：2014-01-01 00:00:00

abstract：:C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, intestinal adenomas and aberrant crypt foci were counted, and serum leve...

journal_title：Cancer research

authors： Jacoby RF,Marshall DJ,Newton MA,Novakovic K,Tutsch K,Cole CE,Lubet RA,Kelloff GJ,Verma A,Moser AR,Dove WF

更新日期：1996-02-15 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:An epitope region, located at amino acid residues 173-180 (EAAA-GIQW), of a human cell proliferation-associated nucleolar antigen, P120, has been defined by mutational analysis and competition assays. A synthetic peptide corresponding to this epitope region completely blocks the binding of the anti-P120 antibody to Es...

journal_title：Cancer research

authors： Valdez BC,Busch RK,Larson RG,Busch H

更新日期：1990-05-01 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00

abstract：:The Wilms' tumor 1 gene (WT1) encodes a transcription factor involved in cell growth and development. As we previously reported, WT1 expression is hardly detectable in normal hepatic tissue but is induced in liver cirrhosis. Although WT1 has been found to be overexpressed in a number of malignancies, the role of WT1 i...

journal_title：Cancer research

authors： Perugorria MJ,Castillo J,Latasa MU,Goñi S,Segura V,Sangro B,Prieto J,Avila MA,Berasain C

更新日期：2009-02-15 00:00:00

abstract：:Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endo...

journal_title：Cancer research

authors： Obata K,Morland SJ,Watson RH,Hitchcock A,Chenevix-Trench G,Thomas EJ,Campbell IG

更新日期：1998-05-15 00:00:00

abstract：:We report on the identification of autoantigens commonly recognized by sera from patients with breast cancer. We selected ten sera from patients with invasive ductal carcinoma (IDC) of the breast with high titer IgG autoantibodies for biopanning of a T7 phage breast cancer cDNA display library. A high throughput metho...

journal_title：Cancer research

authors： Fernández-Madrid F,Tang N,Alansari H,Granda JL,Tait L,Amirikia KC,Moroianu M,Wang X,Karvonen RL

更新日期：2004-08-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC cells also have increased prostaglandin expression (PGE2). Many lung cancers also express 12-lipoxygenase RNA and 12-lipoxygenase protein and biosynthesize 12(S)-hy...

journal_title：Cancer research

authors： Soriano AF,Helfrich B,Chan DC,Heasley LE,Bunn PA Jr,Chou TC

更新日期：1999-12-15 00:00:00

abstract：:The human promyelocytic leukemia cell line HL-60 and monoblastic leukemia cell line U937 undergo differentiation when induced by lymphokine and cytokine preparations. Growth inhibition, acquisition of immunoglobulin Fc receptors, increased expression of monocyte-related surface antigens, and an increase in lysosomal e...

journal_title：Cancer research

authors： Harris PE,Ralph P,Gabrilove J,Welte K,Karmali R,Moore MA

更新日期：1985-07-01 00:00:00

abstract：:Hemodynamic (blood flow rate, hematocrit, hemoglobin concentration, and blood viscosity) and pH responses to glucose (6 g/kg, i.p.) injections were studied in ten Walker 256 carcinoma tumors (0.5-1.8 g) grown in the "tissue-isolated" tumor preparation. A maximum blood flow reduction of 57 +/- 19% (SD) occurred concurr...

journal_title：Cancer research

authors： Sevick EM,Jain RK

更新日期：1988-03-01 00:00:00

abstract：:The expression of genes which may be involved in the regulation of human mammary epithelial cell growth [transforming growth factors alpha and beta] and tumorigenesis [c-myc, erbB2, epidermal growth factor receptor (EGFR), Ha-ras, pS2] has been compared in similarly cultured normal cell strains and tumor cell lines. W...

journal_title：Cancer research

authors： Zajchowski D,Band V,Pauzie N,Tager A,Stampfer M,Sager R

更新日期：1988-12-15 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:The bryostatins are a group of macrocyclic lactones isolated from the marine bryozoan Bugula neritina. Bryostatin 1, like the phorbol esters, activates protein kinase C; however, it partially inhibits the phorbol ester induced differentiation of the human promyelocytic leukemic cell line HL-60. We compared the phospho...

journal_title：Cancer research

authors： Warren BS,Kamano Y,Pettit GR,Blumberg PM

更新日期：1988-11-01 00:00:00

abstract：:The spontaneous development of juvenile-onset ovarian granulosa cell tumors in mice of the SWXJ-9 recombinant inbred strain is a model for juvenile-type granulosa cell tumors that appear in very young girls. To expedite gene discovery in this mouse model of childhood cancer, we did a gene mapping study with the SWXJ-9...

journal_title：Cancer research

authors： Dorward AM,Shultz KL,Horton LG,Li R,Churchill GA,Beamer WG

更新日期：2005-02-15 00:00:00

abstract：:To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes includ...

journal_title：Cancer research

authors： Kadota M,Sato M,Duncan B,Ooshima A,Yang HH,Diaz-Meyer N,Gere S,Kageyama S,Fukuoka J,Nagata T,Tsukada K,Dunn BK,Wakefield LM,Lee MP

更新日期：2009-09-15 00:00:00

abstract：:Tumor antigen-induced inhibition of leukocyte adherence was adapted and modified for use in glass test tubes for the study of cell-mediated antitumor immunity to human adenocarcinoma of the breast. Peripheral blood leukocytes from 40 to 47 patients with proven breast cancer responded to an antigenic extract of breast ...

journal_title：Cancer research

authors： Grosser N,Thomson DM

更新日期：1975-09-01 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1) is a member of the CEA family of immunoglobulin-like adhesion molecules with two major splice variants, CEACAM1(a)-4L and CEACAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail. Both forms are down-regulated in prostate a...

journal_title：Cancer research

authors： Laurie NA,Comegys MM,Carreiro MP,Brown JF,Flanagan DL,Brilliant KE,Hixson DC

更新日期：2005-12-01 00:00:00

abstract：:The binding of tritium-labeled 5-methylchrysene to DNA of CD-1 mouse skin 24 hr after treatment has been studied. DNA was isolated from the treated skin areas of mice and hydrolyzed enzymatically to deoxyribonucleosides, and the hydrolysate was chromatographed on a Sephadex LH-20 column using a methanol:water gradient...

journal_title：Cancer research

authors： Melikian AA,LaVoie EJ,Hecht SS,Hoffmann D

更新日期：1982-04-01 00:00:00