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Differences in complication rates among the centres in the SPACE study.

Abstract：

INTRODUCTION:Despite the high grade of standardisation of study protocols, there is still room for variability among the centres in specific treatment aspects. We evaluated the treatment risk in stent-protected angioplasty of the carotid versus endarterectomy (SPACE) associated with the specific patient enrollment rates of the centres. MATERIALS AND METHODS:The analysed endpoints were ipsilateral stroke or death [primary outcome event (pOE)] and any stroke or death [secondary outcome event (sOE)] until 30 days after treatment. A binary logistic regression analysis with random effects was performed separately for each treatment arm. The centres were secondarily categorised in three classes: I) > or = 25 patients enrolled, II) ten to 24 patients and III) <10 patients and a hierarchic log linear model was fitted to test the three-way interaction of treatment, number of patients per class and outcome. RESULTS:The random effects logistic regression analysis in the carotid artery stenting (CAS) arm proved a significant increase in pOE with decreasing number of patients enrolled (-0.0190 +/- 0.0085, p = 0.025, deviance 35.7 with 32 df), whereas no such effect was found in the carotid endartectomy (CEA) arm (-0.010 +/- 0.008, p = 0.24, deviance 39.78 with 32 df). In the log linear model, there was a significant interaction between treatment, number of patients per centre and sOE (p = 0.023). The odds ratios for sOE in the enrollment classes (CAS vs. CEA) were 0.98 (95% CI 0.50-1.94, p = 0.95) for class I, 1.13 (95% CI 0.47-2.77, p = 0.77) for class II and 11.56 (95% CI 1.40-253.45, p = 0.01) for class III centres. CONCLUSION:Despite rigorous standardisation and quality requirements for operator qualification, there seemed to be a decrease in complication rate with increasing patient enrollment numbers in the CAS arm while this signal could not be detected in the CEA arm of SPACE.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Fiehler J,Jansen O,Berger J,Eckstein HH,Ringleb PA,Stingele R

doi

10.1007/s00234-008-0459-6

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1049-53

issue

eissn

0028-3940

issn

1432-1920

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Differences in complication rates among the centres in the SPACE study.